My Authors
Read all threads
Pharmacy education post***

Why are the benzodiazepines Lorazapem, Oxazepam, and Temazepam recommended in the elderly?

Benzodiazepines are metabolized either through Phase 1 or Phase 2 metabolism
Phase 1 metabolism includes for example oxidation or reduction and turns the parent molecule into a more polar compound and eventual inactivation of the drug. Phase 1 metabolism involves the enzymes CYP2C19 and CYP3A4 and are responsible for benzos that undergo Phase 1..
Phase 2 metabolism involves conjugation of charged compounds and makes it more water soluble facilitating it into the bile or urine. So Phase 1 metabolism tends to decrease in the elderly and Phase 2 metabolism is for the most part preserved..
If you have decreased metabolism of a benzo that increases chances of side effects including cognitive impairment, drowsiness, fatigue. That is not what we want in the elderly. That is why the LOT benzos are recommended because they go through
Correction to above tweet that was deleted:
Phase 2 metabolism which is preserved in the elderly. The BEERS list which is a list of drugs that are potentially dangerous in the elderly!!! #TwitterRx #pharmacy #education
Missing some Tweet in this thread? You can try to force a refresh.

Enjoying this thread?

Keep Current with Ghanaboy.PharmD 💊

Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

Twitter may remove this content at anytime, convert it as a PDF, save and print for later use!

Try unrolling a thread yourself!

how to unroll video

1) Follow Thread Reader App on Twitter so you can easily mention us!

2) Go to a Twitter thread (series of Tweets by the same owner) and mention us with a keyword "unroll" @threadreaderapp unroll

You can practice here first or read more on our help page!

Follow Us on Twitter!

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just three indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!