Also, lots of enthusiasm for hydroxychlorquine, remdesivir
My take on antiviral drugs #COVID19 & why Anthony Fauci agrees (quote) [thread]
However, if you zoom out, 30000 ft view, and consider all anti-viral drugs ever thought to be promising, you would see things differently
Making useful antiviral drugs is not easy.
Many common virus still have suboptimal therapies (CMV, HSV1/2).
Our approved drugs are often marginal.
As is often the case in medicine, while it is nice to see in-vitro evidence of antiviral activity, that is nothing to hang your hat on.
Even if the evidence is weak or lousy, what do we have to lose?
(not very useful in a condition where many but not all pts improve)
Worse, many trials measure unproven surrogates such as viral measurements based on swabs.
No one knows how to interpret these endpoints
But, what does that mean?
We should use off protocol? -
Sadly, that's how we got in this mess
And the pretest prob any of these drugs help is probably v. v. low, sadly
Some similar trials are ongoing.