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nature.com/articles/s4159…

1/ Full resolution of symptoms after viral infection subsided (> day 7).

"The emergence and rapid increase in activated CD38+HLA-DR+ T cells, especially CD8+ T cells, at days 7–9 preceded the resolution of symptoms. "
2/ However, suppressed antibody-secreting cells were observed in #COVID19 patients.

According to this article about half of the patients experience digestive symptoms.

journals.lww.com/ajg/Documents/…
3/ "Patients with digestive symptoms had a significantly
longer time from onset to admission than patients without digestive symptoms (9.0 days vs.
7.3 days). Overall, people without digestive symptoms appeared to be more likely to ...
4/ ... recover from COVID-19 and be discharged from the hospital than those with digestive symptoms, at a ratio of 60% in the former group to 34.3% in the latter.

Well ... 100% of #COVID19 patients pass from sepsis induced cytokine storm related ARDS symptoms. "The gut is ..
5/ ...thought to be the "motor" of such septic states and the first step of a "gut-liver-lung axis. Shock of any type or sepsis can by themselves lead to increased permeability of the intestinal mucosal barrier. "

europepmc.org/article/med/19…
6/ Well, my point is that #VitaminC restores the gut-liver-lung functions in vulnerable metabolic systems. It remains unclear whether high doses of VitaminC orally has any benefit on the prevention of sepsis induced #cytokinestorm related ARDS symptoms.

ncbi.nlm.nih.gov/pmc/articles/P…
7/ "Poor ascorbate status likely drives gut inflammation resulting in barrier dysfunction, which increases LPS absorption, that causes endotoxemia and decreased absorption of ascorbate, promoting a cycle of increasing inflammation and oxidative damage that ...
8/ ... also further decreases both ascorbate and α-TOH status. Inflammation likely also drives systemic depletion of ascorbate, as shown in sepsis patients, who despite receiving 50 or 200 mg still become deficient in vitamin C due to heightened ...
9/ ... immune responses in septic shock that increase the rate of oxidation vitamin C, resulting in its depletion."

In this study Alveolar TNF-α, a key mediator of alveolar inflammation in ARDS, was significantly correlated with altered lung microbiota. Results demonstrate...
10/

... that the lung microbiome is enriched with gut-associated bacteria in sepsis and ARDS, potentially representing a shared mechanism of pathogenesis in these common and lethal diseases.

nature.com/articles/nmicr…
11/ I am not a GP, but I believe that after 7 days.... your gut-liver-lung axis either shifts to recovery, or goes into septic-shock and #cytokinestorm induced ARDS symptoms follow; damage to the liver, lungs, cardiovascular system, and possible intracerebral hemorrhages. And..
12/ ... that you might restore gut-liver-lung microbiota to prevent or mitigate the effects of sepsis induced #cytokinestorm related ARDS symptoms by taking high doses of oral #VitaminC, as was demonstrated to be deficient in sepsis-patients.

#CoronaVirusUpdate #Covid_19
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