So important to support grad students now. Many are wondering whether their rotations will be extended & when they are expected to match with labs. PIs should be in touch with their students & students should realize this is a real world test of lab life under stress conditions/1
As I said in yesterday's fac mtg, if a student rotated in 2 equally exciting labs, 1 which requires lab visits to mate crocodiles & 1 which can function with ppl @ home, their current experience is telling them which lab to join in 2020 /3
While we should accommodate students who need more time, we should also realize that some labs are extraordinarily productive now & that work brings the satisfaction that students are seeking by deciding to pursue PhD /4
Logical conclusion is that we should encourage PIs to meet with students about lab prospects in the current environment & let students match with labs on schedule if they so choose #scitwitter#gradschool
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today @davidasinclair is telling the world that he has achieved age reversal with chemical cocktails
he submitted the paper on June 30 & it was accepted on July 4 by a journal of which he is coeditor-in-chief
paper was sent to me 3 days ago by a reporter for comment
reporter was told it is a "groundbreaking study" & "the first chemical approach to reprogram cells to a younger state"
reason WSJ didn't cover that paper is that ppl have been reporting chemical compounds that drive conversion of cells to induced pluripotency for the last 10-15 years
all of the compounds in today's paper were previously reported by others, mostly in 2013
there's a peer review failure today doi.org/10.1016/j.cell… in which an individual with 59 collaborators claims to have tested the information theory of aging
he did not test the information theory of aging
the claim is that he induced dsDNA breaks that are easily repaired, don't cause a DNA damage response or mutagenesis or cell death--only an epigenetic change
he knows this is not true because his co-first author & he published this paper in dec '21
there are a few issues being addressed here. let’s start w safety
human placebo controlled trials have never shown adverse events attributable to Niagen. note that LDL-C is raised in humans w Basis & pterostilbene alone
the class of compounds to which NR belongs is vitamin B3
there are decades of human data on these molecules showing human safety. niacin is unique in causing flushing but nicotinamide was tested in large Australian skin cancer and was shown to be cancer-preventative in ppl
there’s a hierarchy of evidence w human RCTs (and meta-analysis of RCTs) on the top. human case reports & good quality rodent studies are lower. cell studies are lower. poorly conducted rodent and/or poorly conducted cell studies are garbage in/garbage out