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Did you restrict the randomisation procedure by centre? Then you'd better reflect this in the analysis. How? Will you use fixed or random intercepts? Something else?
2/
Uh-oh, did someone say 'intercurrent events'? Yes, participants are real people and things happen to them! Now estimands get complicated.
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Careful – in the RCT context we have to write our statistical analysis plan unambiguously before seeing the data (because if you decide on your analysis based on seeing the data, things go awry).
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Trial statos, what fun complexities of trial analysis did I miss?
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