Men —> more ACE2
Post menopausal women —> more ACE2
Pregnant women —> higher risk for clot —> ACE2 expression increases in normal pregnancy 2nd trimester
Diabetes, HTN, Smoking —> preexisting vascular damage
Neurology Today (Italy interview):
"There is a dramatic increase in the number of vascular events, ischemic strokes, and thrombosis..."
“We are performing daily echo on our patients in the ICU. We are seeing a number of patients with echo signs of pulmonary embolism (dilated right ventricle, tricuspid regurgitation). These patients are typically in the ICU...
Abnormal Coagulation Parameters Are Associated With Poor Prognosis in Patients With Novel Coronavirus Pneumonia (China)
Anticoagulant Treatment Is Associated With Decreased Mortality in Severe Coronavirus Disease 2019 Patients With Coagulopathy (China)
"Physiology of COVID19 pneumonitis has the gist of shunt way out of proportion to lung injury. This suggests specific dysregulation of the pulmonary vascular compartment. Here is a hypothesis to explain why this might be the case..."
I just keep asking questions.
Have to do something with my COVID-induced insomnia #WhenImUpAtNight
ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy