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1. This Thread will attempt to gather information on the potential treatment of Quercetin and Zinc against COVID-19. I will try to include various studies,articles,anecdotal evidence to help establish a case for its potential anti-viral effects especially when taken early on.
2. Current study by renowned Montreal Researchers in the potential treatment of Quercetin against COVID-19:
mcgilltribune.com/sci-tech/montr…
3. Study receives 1 million dollar donation to initiate trials in China: ircm.qc.ca/en/news/lazari…
4. More press on the trial: macleans.ca/news/canada/a-…
5. Radio interview with the leading researchers, Dr Michel Chrétien and Dr Majambu Mbikay:
cbc.ca/player/play/17…
7. What is Quercetin? Here is a great article on its nature;benefits;foods;dosage;side effects.
healthline.com/nutrition/quer…
8. What is Zinc? A great article on the benefits of Zinc:
healthline.com/nutrition/zinc…
9. I will now proceed to link various studies that deal with the benefits of Quercetin, especially it’s potential against diseases, bacteria and viruses.
10. Study of Quercetin efficacy against SARS- Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003:
jvi.asm.org/content/78/20/…
11. Study of Quercetin efficacy on Influenza A Virus:
ncbi.nlm.nih.gov/pmc/articles/P…
12. Study of Quercetin efficacy on Ebola:
aac.asm.org/content/60/9/5…
13. Study of Quercetin efficacy on Hepatitis C Virus:
nature.com/articles/srep3…
14. Study of Quercetin on Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer:
ncbi.nlm.nih.gov/pubmed/19149749
15. Study on suppression of cancer cell growth and inducing cell death in Prostate cancer cells:
spandidos-publications.com/or/33/6/2659
16. And this Study as well: ncbi.nlm.nih.gov/pubmed/32174789
17. Here is other Quercetin anti-cancer research on test tube and animal studies on liver, lung, breast, bladder, blood, colon, ovarian, lymphoid, and adrenal cancer cells:
A. ncbi.nlm.nih.gov/pubmed/28677813
B. ncbi.nlm.nih.gov/pubmed/28264020
C. ncbi.nlm.nih.gov/pubmed/24223637
D. ncbi.nlm.nih.gov/pubmed/27186419
18. Here are Studies of some positive effects of Quercetin on Alzheimer’s disease and Dementia:
A. ncbi.nlm.nih.gov/pubmed/26904161
B. ncbi.nlm.nih.gov/pubmed/25666032
C. ncbi.nlm.nih.gov/pubmed/29736217
19. Here are some studies of the effects of Quercetin on High blood pressure:
A. ncbi.nlm.nih.gov/pubmed/1206570…
B. ncbi.nlm.nih.gov/pubmed/8919657/
C. ncbi.nlm.nih.gov/pubmed/11325801
D. ncbi.nlm.nih.gov/pubmed/27405810
20. Studies on the effect of Quercetin on combatting aging:
A. ncbi.nlm.nih.gov/pubmed/28966753
B. ncbi.nlm.nih.gov/pubmed/29988130
C. ncbi.nlm.nih.gov/pubmed/29737207
21. Studies on the effects of Quercetin to aid blood sugar levels in Diabetics:
A. ncbi.nlm.nih.gov/pubmed/30848564
B. ncbi.nlm.nih.gov/pubmed/30735748
C. ncbi.nlm.nih.gov/pubmed/30551359
22. Here is a study on the anti-inflammatory properties of Quercetin. It is specifically important given the potential of inhibiting the high cytokine storm induced by Covid-19,causing major complications like pneumonia etc.
ncbi.nlm.nih.gov/pmc/articles/P…
23. Here’s another study on the anti inflammatory properties of Quercetin where we see inhibition of pro inflammatory cytokines:
cvi.asm.org/content/13/3/3…
24. In test-tube studies, quercetin reduced markers of inflammation in human cells, including the molecules tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6). Here are two studies with regard to that:
A. ncbi.nlm.nih.gov/pubmed/20943792
B. ncbi.nlm.nih.gov/pubmed/27294919
25. An 8-week study in 50 women with rheumatoid arthritis observed that participants who took 500 mg of quercetin experienced significantly reduced early-morning stiffness, morning pain, and after-activity pain. They had reduced markers of inflammation: ncbi.nlm.nih.gov/pubmed/27710596
26. Quercetin’s anti-inflammatory properties may provide allergy symptom relief. Studies found that it may block inflammatory enzymes and suppress inflammation-promoting chemicals, such as histamine.
A. ncbi.nlm.nih.gov/pubmed/27187333
B. ncbi.nlm.nih.gov/pubmed/18187018
C. ncbi.nlm.nih.gov/pubmed/21625024
27. Another study showed that taking quercetin supplements suppressed peanut-related anaphylactic reactions in mice:
ncbi.nlm.nih.gov/pubmed/20548131
28. Here is a study with regard to Quercetin’s efficacy on inhibiting the Zika virus:
biorxiv.org/content/10.110…
29. Now let’s turn our attention to the possible effects of Quercetin on SARS-COV-2, otherwise known as COVID-19.
There are various ways Quercetin may be effective in inhibiting the effects of the coronavirus.
30. 1) Blocking Entry of Virus. Supercomputer simulations by the University of Tennessee and Oak Ridge National Labs to demonstrate which FDA approved chemical compounds may interfere with the coronavirus binding to cells. Out of 8000,Quercetin came in #5.
chemrxiv.org/articles/Repur…
32. Yet more detail on the mechanism of how Quercetin may block virus entry into cells. Here is the table from the Supercomputer simulation mentioned above:
33. This seems to be the mechanism proposed by the Montreal researchers mentioned above. Here is a piece of the article mentioned above: mcgilltribune.com/sci-tech/montr…
34. 2) Quercetin acts as a Zinc Ionophore, allowing Zinc to pass the cell membrane and thereby inhibit the replication of the virus. Here is the study demonstrating this:
pubs.acs.org/doi/full/10.10…
35. This is essentially the same process behind chloroquine/Hydroxychloroquine as they are both Zinc Ionophores. This is one of the leading theories behind their efficacy as anti-viral drugs.
ncbi.nlm.nih.gov/pmc/articles/P…
36. Here is a great video demonstrating how chloroquine/Hydroxychloroquine work as zinc ionophores to inhibit virus replication:
37. As an aside I would like to share two recent documents showing the strong efficacy of Hydroxychloroquine and Zinc in fighting Covid-19.
A)docs.google.com/document/u/0/d…
38. B) Here is the second document on Hydroxychloroquine’s efficacy on treating COVID-19:
docs.google.com/document/d/1O6…
39. Zinc- The following is a study showing Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture:
ncbi.nlm.nih.gov/pmc/articles/P…
40. Here is a trial on the efficacy of Zinc on the common cold: ncbi.nlm.nih.gov/pubmed/15496046
42. This is a very detailed explanation on the connection between chloroquine, zinc and Quercetin and illustrates clearly how they share similar mechanisms.
dadamo.com/dangerous/2020…
43. 3) Another reason why Quercetin may be effective at combatting COVID19 is due to the fact that it may inhibit the cytokine storm induced by the coronavirus:
ncbi.nlm.nih.gov/pmc/articles/P…
44. 4) Another potential Quercetin anti-Covid-19 mechanism:
47. I will now proceed to link articles and videos related to Quercetin’s potential to fight COVID-19.
48. Can quercetin help us to avoid the threat of coronavirus infection? | Journal Online
journal.com.ph/news/world/bre…
50. Combating Covid-19 with Zinc and Quercetin:
nutritionalpharmacology.wordpress.com/2020/03/22/com…
51. Quercetin vs CoVid19 (Powerful anti-viral properties of this unique nutrient):
thenutritionwatchdog.com/quercetin-vs-c…
52. Can Quercetin Treat Coronavirus Infection?supplementclarity.com/does-quercetin…
53. Mast Cell Activation & Coronavirus: Is Quercetin Effective Against COVID-19?
mastcelldisease.com/mast-cell-acti…
54. Quercetin as Zinc Ionophore and COVID-19 Outpatient Management By DrBeen Medical Lectures:
55. MedCram Video Update #35- This was one of the first mentions on the potential of Quercetin to act as a Zinc Ionophore like Hydroxychloroquine to inhibit virus replication, thereby potentially acting as a treatment for SARS-COV-2/ COVID-19:
56. Eastern Virginia Medical School Critical Care COVID-19 Management Protocol & earlier treatment recommendation/ They recommend Quercetin 250mg-500mg each day.
evms.edu/media/evms_pub…
57. It also part of the daily regimen by Harvard Researcher, David Sinclair. blog.daveasprey.com/wp-content/upl…
58. I will now proceed to provide anecdotal evidence of people who took Quercetin/Zinc as a remedy for COVID-19. Thank you @ScarofOdysseusfor collecting many of these cases and your ongoing work on providing anecdotal support to this potential treatment.
86. This doctor got better after using a cocktail of supplements that included Quercetin.
theglobeandmail.com/life/first-per…
88. I found some Anecdotal Quercetin cases on YT comments as well....
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99. Here is a new study in Turkey that will study the prophylaxis and treatment of Quercetin for Covid-19:
clinicaltrials.gov/ct2/show/NCT04…
102. This is a follow up detailed report for an earlier report:
107.
108. Great thread on Quercetin’s potential immunity response:
109. New trial underway for Isoquercetin for high risk prevention in COVID-19:
sph.umich.edu/biostat/covid1…
110. New trial in Canada by Dr Michel Chretien’s team:
icav-citav.com/icav_news/isoq…
111. Another report where Quercetin helped:
114. Early Clinical trial data looks promising for Quercetin:
124. New Quercetin Trial in Saudi Arabia:
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