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Vitamin D attenuates acute lung injury by increasing ACE2 expression, allowing more Ang II to be converted into Ang 1-7 (and Ang-I into Ang 1-9) and inhibiting renin and the ACE/Ang II/AT1R cascade.
The best medicine for preventing severe COVID-19 is sufficient sunlight exposure.
By increasing ACE2 expression, "Vitamin D indeed feeds the “Fountain of Youth” and allows one to age well by delaying fractures,
ectopic calcification, oxidative damage, infections, autoimmunity, inflammation, pain,
cardiovascular disease, & malignancy"
Supplementation with Vitamin D through the diet or oral supplements has generally been shown to be ineffective at treating Vitamin D inadequacy or deficiency.
In other words, Vitamin D sources other than sunlight have not been proven to be effective.
In a UK study, vitamin D supplementation increased vitamin D levels in healthy white men, but decreased vitamin D levels in healthy UK South Asian men.
It is possible that the biologic effects of Vitamin D sources other than sunlight may vary by race.
"there might toxic consequences to the relatively sun-deprived, Vitamin D-deprived culture of modern society that includes clothing to cover 95% of our Vitamin D-forming skin surface, avoiding time in the sun, and migration to wintery, temperate climates."
"The list of potential health consequences of modern life must include the diseases whose prevalence correlates with latitude and UVB exposure. These include hypertension, greater risk of breast, colon, and prostate cancers, multiple sclerosis, & diabetes"
Moreover, closed environments have been associated with secondary transmission of COVID-19 & promotion of superspreading events.
The combination of fresh air and sunlight should promote lower susceptibility to severe symptoms COVID-19 & critical illness.
A particular reason why supplementation cannot be relied upon as a source of Vitamin D, particularly for people of non-white racial backgrounds
Vitamin D supplementation can cause an overactive parathyroid, which can lead to hypercalcemia and many diseases
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