What we've seen so far in the US is actually fairly widespread compliance with public health directives and support for maintaining them.
Especially if their local leaders own the implementation and explain the necessity, as they have with distancing measures.
Similar to the reopening protests, will this minority of people get amplified by public figures for political ends?
In fact we're all too aware; we navigate them everywhere. Suspicion and mistrust are not unique to the US - try running contact tracing in Congo some time.