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Suzanne Fustolo-Gunnink

May 13, 2020 • 4 tweets • 2 min read • Read on X

@EBNEO

Are you a neonatologist, hematologist, transfusion expert, epidemiologist or statistician and interested in neonatal transfusion research? Contact me and join a neonatal transfusion network in-the-making. Trainees and ECR welcome. @EBNEO @blooducation #epitwitter #statstwitter

I forgot to mention a very important group: fundamental researchers are also invited to join.

Wow, lots of response. Perhaps good to clarify that we will have quite a strong focus on Europe, but ofcourse are open to participants from all over the world.

Thanks for all of your replies, likes and retweets, it is great to see so much interest for this topic. For those of you who replied: I will try to contact you within the next 2 weeks. If I don’t have your email address: please send it to me via a personal message.

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More from @FustoloSuzanne

Suzanne Fustolo-Gunnink

@FustoloSuzanne

Sep 21, 2020

@Atul_Monash

Lots of variation in practice in this poll looking at prophylactic platelet transfusions for preterm neonates. What’s the evidence? @Atul_Monash suggested a tweetorial, which is a first for me, but here we go. 1/13

https://twitter.com/ebneo/status/1305708930010624000

@PlaNeT2_trial

We give platelet transfusions to preterm neonates to a) treat bleeding or b) prevent bleeding (prophylaxis). Most transfusions are prophylactic. Do they reduce risk of bleeding? Up until the @PlaNeT2_trial, no one knew. doi.org/10.1182/blood-… and sciencedirect.com/science/articl…

The only previous trial by dr. Maureen Andrew and her group was published in 1993 and compared a threshold of 50x10^9 vs 150x10^9 which is higher than currently used in clinical practice. There was no difference in IVH rates between the 2 groups. doi.org/10.1016/S0022-….

Read 14 tweets

Suzanne Fustolo-Gunnink

@FustoloSuzanne

Oct 25, 2019

@PlaNeT2_trial

2dary analysis of @PlaNeT2_trial out now. @KDraat @ESteyerberg @Willem_Pieter @BloodJournal #ebneo #FOAMneo #neohematol . A thread. Primary result of trial: more bleeding/death in neonates treated acc to prophylactic platelet tx threshold of 50 comp to 25. 1/3

We reanalyzed the data to look for subgroups of neonates that might benefit from the 50 threshold after all. Instead of using conventional subgroup analyses we used a more robust predicted baseline risk approach. More info? Start reading here: doi.org/10.1136/bmj.k4… 2/3

@sanquin

We did not identify subgroups that benefit from the 50 threshold, though model needs further improvement. Suggests prophylactic platelet tx threshold of 25 appropriate for all preterm neonates, incl those at high risk of bleed/mortality. 3/3 @sanquin @LUMC_Leiden @amsterdamumc

Read 4 tweets

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