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1/ A little over a year ago I got a compilation of data from @DrRagnar's team from the NHANES dataset. Over the last month I've been working with biostatistician on a much deeper dive, including a complete reconstruction of our local dataset from scratch - adding in many new vars
2/ This time around, we're adding in data from underlying conditions, alcohol use, and smoking -- as well as inclusion of metrics such as fasting insulin and C-Reactive protein (CRP).

But the biggie I've been excited about is ApoB...
3/ In particular, I'm interested in the "ApoB Triad" of high ApoB + high HDL cholesterol + low triglycerides vs All Cause Mortality

How much does inflammation matter? Underlying conditions? Age?

And of course, will those with this triad show more or less longevity overall?
4/ All these questions I'll be exploring at length in my talk next month.

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Dave Feldman
@DaveKeto
1/ I enjoyed reading through a thread from @KetoCarnivore yesterday pushing back on the term "processed" as effectively interchangeable with "junk food". (And to be sure, this view is also well represented by @siobhan_huggins and @bokkiedog). The point is very well taken...
2/ I myself use the term "processed foods" in this fashion a lot and I'm going to work at being more specific/descriptive instead. But I'll concede this is certainly a commonly used term with a commonly assumed context that will be tough to unlearn...
3/ I guess you can say I'm going to have a tough time quitting "processed foods" 😂
Read 3 tweets
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Dave Feldman
@DaveKeto
1/ Update on #TheCCDoc... In case you missed the announcement and postings, it's a documentary we literally went around the world shooting in Jan/Feb right before you-know-what happened.

I've considered it on hold until we can resume traveling, but a new idea opened up...
2/ For many evenings (including this one), I've been converting raw footage shot and have been surprised on just how much we captured, both in the interviews and in b-roll. We were in such a groove gathering everything, and I find there's quite a lot I forgot about until now.
3/ Every interview I've done opened with some biography of the interviewee and then ultimately we discussed cholesterol, treatment, etc.

What has been surprising is just how many incredible stories are shared in that first portion of the dialog...
Read 5 tweets
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Dave Feldman
@DaveKeto
1/ I'm looking forward to covering Bradford Hill in an upcoming presentation. I find there's often a misconception that he introduced a low standard to claim causality with epidemiological data. Actually, he was far stricter than he's been portrayed... edwardtufte.com/tufte/hill
2/ Many are quick to claim they've helped to demonstrate causality using his criteria (sometimes just a few criteria, not all). But he's already remarked on many occasions how important each of these are taken together -- and likewise given examples to demonstrate.
3/ In other words, I think he himself would likely disagree with the vast majority of the modern claims made about meeting his criteria.

The first two, Strength and Consistency, are arguably the most intuitive and yet hardest to meet.
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