We characterized the unrecognized severity spectrum of primary aldosteronism
Findings suggest a need to reframe/redefine clinical approaches and terminology to reflect that PA is a common syndrome that can manifest across the blood pressure continuum/1
acpjournals.org/doi/10.7326/M2…
Findings suggest a need to reframe/redefine clinical approaches and terminology to reflect that PA is a common syndrome that can manifest across the blood pressure continuum/1
acpjournals.org/doi/10.7326/M2…
First - very grateful to be able to work with this stellar team: @JeniferBrown for countless hours of hard work and dedication (and years working to better characterize PA), and the collaborative wisdom of @msiddiqui_, Bob Carey, David Calhoun, Gordon Williams, Paul Hopkins /2
Every participant had physiologic confirmatory testing (oral sodium suppression) regardless of arbitrary screening indications or ARR thresholds
Figs: the magnitude and continuous distribution of non-suppressible, renin-independent, 24h aldosterone production by BP phenotype/3
Figs: the magnitude and continuous distribution of non-suppressible, renin-independent, 24h aldosterone production by BP phenotype/3
We emphasize: excessive focus on binary diagnostic thresholds overlooks the continuum of renin-independent aldosterone production that transcends these categorizations - recognizing the severity spectrum seems more important than focusing on arbitrary prevalence point estimates/4
Some key excerpts /5
Excerpt with some historical perspective below - for more comprehensive history and physiology of the primary aldosteronism syndrome (free downloads) /7
academic.oup.com/edrv/article/3…
acpjournals.org/doi/10.7326/M1…
academic.oup.com/edrv/article/3…
acpjournals.org/doi/10.7326/M1…
