Oxford data consistent w/ past results... uncomfortable & fairly weak neutralizing antibody titers compared to other vaccines (until we get outcomes from large studies, we can't know if good enough). Touted t cells aren't well understood w/o strong nAbs. marlin-prod.literatumonline.com/pb-assets/Lanc…
Which is to say, media overhyped it but reasonable to test in larger studies to see if it protects. If it does, good; & we can expect better results from better vaccines coming up behind. If doesn't protect, that's ok, b/c others are likely better. Looking forward to more data.
But vaccines like Oxford's, which also generate immunity against adenoviral vector (coating delivering the vaccine instructions) probably won't be as good for seasonal reboosting. Our immune system shuts them down better after each dose, preventing delivery of instructions.
Think of AI computer that gets more and more disgusted with a thumb drive you use to deliver instructions, eventually refusing to accept whatever is on that thumb drive. By comparison, other vaccines upload instructions wirelessly, so no thumb drive for computer to reject.
So Oxford vaccine has to do all it can with the initial course of vaccination. After that, boosting of SARS2 immunity will likely need other vaccines. Same redosing limitations apply to all adenoviral vaccines (e.g. JNJ, Cansino)
Also, Cansino adenoviral vaccine data were disappointing. To quote a colleague: "No industrialized country should want this vaccine." (lower left panel shows minuscule neutralizing titers). Weak Oxford's data today were better than this. marlin-prod.literatumonline.com/pb-assets/Lanc… 
Of clinical data announced so far, mRNA vaccines have been most compelling. Showed neutralizing antibody levels slightly higher than in serum of people who recovered from COVID. Con is they hurt (tolerability); would be worth it to end pandemic but prob not for seasonal boosters.
Lots more data coming. I love how much we are learning about different vaccine platforms. We're not just going to develop the best COVID vaccines. We're going to understand the pros/cons of many technologies so we can develop the best vaccines for many other diseases.
