Yesterday I met with our fantastic BMSes and MLAs to go over interesting/tricky cases this week. We talked about indications for washed platelets. #blooducation
Washed platelets are indicated in order to reduce risk of
Washed platelets are given to patients with a history of recurrent allergic reactions. Allergy is usually to proteins in the plasma element of the platelet unit, so removing the plasma reduces the risk.
Standard pooled platelets from @NHSBT are now in 65% PAS (additive solution) and 35% (male) plasma. Apheresis platelets are in plasma. Washed platelets are in "100%" PAS.
The shelf life of washed platelets is 24 hours because the closed circuit is breached, thus increasing the risk of bacterial contamination.
In addition, the yield of washed platelets is lower. So while washed platelets are helpful for those who need them, they should only be used when there is an appropriate indication.
Typically washed platelets need to be requested 24h in advance, but as always, if you need something, ask! We will do what we can to provide what you need.
I should have taken a picture of some washed platelets to show you... watch this space... @TransfusionGeek@JessCaldecott ? 😬
A picture of a standard bag of platelets and a bag of washed platelets. Who can tell me which is which?? Courtesy of @JessCaldecott 🙏
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I had a personal request to do a tweetorial for the #haemSpRs on haemovigilance. Here goes. A #blooducation 🧵
Haemovigilance is a systematic surveillance of adverse reactions and adverse events related to transfusion’ with the aim of improving transfusion safety. transfusionguidelines.org/transfusion-ha…
We are very lucky in the UK to have @SHOTHV1, one of the first in the world to collate adverse events relating to transfusion - since the 1990s.
This morning I met with the chair and vice chair of the Midlands Regional Transfusion Committee, the Midlands Patient Blood Management Practitioner and the Customer Services Manager. What are their roles and what does the RTC do?
A #blooducation 🧵
RTCs serve to bring together Hospital Transfusion Committees to discuss best practice, implement new guidance and provide educational resources and events. They are run by clinicians and scientists working in hospitals, supported by @NHSBT.
Teaching our incoming haematology doctors today about transfusion in haematology patients. So who needs irradiated blood and why? A #blooducation🧵
All blood in the UK is leucocyte reduced (except granulocytes, but that’s another story). Despite this, a unit of red cells or platelets can have around a million residual white cells, mostly lymphocytes.
Every doctor starting in a new trust does transfusion training as part of their mandatory training. But why?
50ml ABO incompatible blood can kill a patient. ABO antibodies are naturally occurring (“everyone” has them) and they are IgM; they can activate complement and cause *immediate* intravascular haemolysis, causing release of free haem, endothelial activation, renal failure and DIC.
In most hospitals, blood banks require 2 samples (one may be historic) before releasing group specific (non-O) blood for a patient. This is to increase the chances of identifying a *wrong blood in tube* (pt whose blood's in the tube is not the pt whose details are on the outside)
It can be difficult to know where to start with transfusion – you can’t go on a ward round to find patients. BUT you do start with lab induction and your helpful #BMSes will show you around.
Excellent session on emergency paediatric transfusion #AABB20. Cyril Jacquot talking on pre hospital transfusion and summarising the literature.
28 day mortality following haemorrhage is higher in children than adults (unpublished data and substudies from PROPPR and PROMMTT)
Observational studies of large numbers of patients but with only very small numbers of paediatric patients suggest that pre hospital blood is not associated with an excess of transfusion reactions and in some studies is thought to have improved survival.
Whole blood, group O, high titre neg, used in paediatrics in Pittsburgh appears to be safe with no haemolysin-mediated haemoylsis in non group O patients (Leeper et al JAMA Pediatrics 2018) ncbi.nlm.nih.gov/pmc/articles/P…