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P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
@Mangan150
Jul 24, 2020 • 4 tweets • 1 min read • Read on X
The bad science of saturated fat has also pushed a great deal of aging research in the wrong direction.

The fact is, much of aging is driven by high insulin.
Looks like absence of carbohydrates does more for lifespan than not eating meat - which does nothing at all.
sciencedirect.com/science/articl…
Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan

"lowered insulin caused significant lifespan extension, observed across two diverse diets"

sciencedirect.com/science/articl…
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

"a reduction of fat mass without caloric restriction can be associated with increased longevity in mice, possibly through effects on insulin signaling"

science.sciencemag.org/content/299/56…

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More from @Mangan150

P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Apr 16
A friend asked ChatGPT what were the most important non-consensus things it has picked up in health, longevity, and healthspan.

First 4 are things I've been talking about a long time.

I'm kinda stunned.

In the follow up, the Chat gave me credit.Image
Image
ChatGPT references

1. Iron as a longevity target

The fine control of body iron stores would be a wise strategy for chemoprevention of several diseases. Image
Glycine and aging: glycine extends lifespan. Image
Read 5 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Apr 14
More muscle means lower risk of diabetes

Every 1% decrease in appendicular (legs and arms) muscle mass in proportion to body weight is associated with 30% increased risk of diabetes.

Build muscle and stay healthy. Image
In reality, the increased risk of prediabetes and diabetes with age is almost entirely due to

*increased body fat
*less muscle
*less exercise

Don't gain body fat, build muscle with resistance training, and stay physically active.
You lose muscle as you age.

In old age, someone can have lost 50% of the muscle they had when young.

You can prevent this through resistance training.

Get plenty of protein too. Image
Read 4 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Mar 31
Could we prevent most cancer cases?

My answer is yes.

Here's why:Image
We know that cancer rates increase dramatically with age.

About 90% of all cancers happen to people over the age of 50.

For age 70 and up, it’s 50% of all cancers.
Now we must ask, why does almost every cancer case happen later in life?

Could it be linked to metabolic health, the way most serious diseases are? Image
Read 12 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Feb 3
I'm turning 70 in a few weeks.

And today, I'm sharing the most important lesson I've learned about exercise and fat loss.

And in doing so...

I want to help you avoid making the most common mistake people make when they decide to get lean and fit.

Let's dive in: Image
In my experience...

Most people who begin a body transformation journey do so with the idea that...

In order to achieve their goal...

They'll need to exercise for an hour per day.
Let me tell you, after working 1-on-1 with over 1300 people...

I've realized that it's often counter-productive to commit so much time to exercise.

There are a few reasons why...
Read 20 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jan 15
Many new followers today, so let me introduce myself.

I'm turning 70 in a few months, and these days I read, write and work with my 1-on-1 clients.

Previously, I was a microbiologist.

I'm linking some of my favorite posts below: Image
The science that most influenced my thinking about health and fitness:
My training methodology to get results in one hour per week:

Read 8 tweets
P.D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
Jun 25, 2024
Cholesterol is so important for brain health that the brain has its own synthetic machinery for making it.

The brain is only 2% of body weight yet contains as much as 25% of the body's cholesterol. Image
Blood levels of total and LDL cholesterol are lower in Parkinson's disease patients.

Ferritin (iron) levels are higher.

[PMID: 21282940]
Some statins, those that are lipophilic, can penetrate the blood brain barrier.

The effects of these statins has been described as "pleiotropic", meaning they do lots of things; since they lower cholesterol, presumably many of these things are not good. https://doi.org/10.1016/j.bbamem.2020.183340
Read 6 tweets

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