@DrJenGunter Great question. I think the most likely causes are:
1) Viral load at time of exposure
Masks help reduce load at exposure and reduce severity of infections.
2) Genetic susceptibility: we now have data from the identical twins studies of TLR7 mutations in X Chromosome.
1) Viral load at time of exposure
Masks help reduce load at exposure and reduce severity of infections.
2) Genetic susceptibility: we now have data from the identical twins studies of TLR7 mutations in X Chromosome.
@DrJenGunter 3) ABO group and Rh: Data that Group A has more severe, and Group O and Rh- have less severe. Mechanism not clear but polymorphisms study in NEJM has clues
4) Cross reactive immunity - antibody or T cells from prior corona virus infections - lot of data on this now.
4) Cross reactive immunity - antibody or T cells from prior corona virus infections - lot of data on this now.
@DrJenGunter 5) Revved up immune system from childhood vaccines especially MMR or BCG potentially conferring a heightened immune response and explaining milder disease in kids.
These are factors I’ve been discussing for months. I think they are all playing a role.
These are factors I’ve been discussing for months. I think they are all playing a role.
@DrJenGunter What I’m certain are not factors are using meds like HCQ which are dangerous and have no role in COVID
