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Ian Seiple Profile picture
@IanSeiple
Aug 17, 2020 • 4 tweets • 1 min read • Read on X
1/ Does anybody have pro tips on navigating the #ACSFall2020 schedule? I have added a lot of the ORGN content to my schedule (which took a while), but I'm worried that I'm missing on other content and I don't have the time to click through all of these nested categories...
2/ ... in other divisions. I'm really annoyed that I cant see the speakers until you click through several levels of nested navigation. Any way to avoid this?? I lost my patience after going through one day of ORGN.
To highlight this challenge: I would never have found my own talk in BIOL if I didn't already know about it. Simply because it's a different division and it takes SO much time to go through each one.
New challenge: There is no link to the On Demand sessions in My Scheduler?? You have to go through a search on the parent website, even if you have it on your schedule? oof....

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More from @IanSeiple

Ian Seiple Profile picture
Sep 23, 2020
[thread] It's finally here! We used chemical synthesis and cutting-edge cryo-EM to engineer streptogramin antibiotics that overcome an ancient resistance mechanism. The story is out today in @nature, and I'll provide a brief summary here. 1/8 https://www.nature.com/articles/s41586-020-2761-3
Dr. Qi Li developed the route and led the chemistry team. Jenna Pellegrino and @d_john_lee in @fraser_lab pushed the limits of ribosome cryo-EM. Over a dozen other co-authors from four continents contributed. Special thanks to Daniel Blair and Marty Burke for the @NatureNews! 2/8 https://www.nature.com/articles/d41586-020-02565-1
Streptogramin antibiotics comprise two structural sub-classes: group A and group B. A primary resistance mechanism for group A streptogramins is deactivation by Vat proteins. These acetylate the C14 alcohol in the 23-membered macrocycle, preventing binding to the ribosome. 3/8
Read 8 tweets
Ian Seiple Profile picture
Aug 27, 2020
Campus👏parking👏should👏be👏free👏during👏a👏public👏health👏crisis. (actually, always). A short thread. @UCSF 1/6
Trainees are paying up to $300/month to park so they can do their work, much of which is COVID-related. Cannot work from home like PIs. Only other option for many people is public transportation, which has inherent risk and is running at reduced schedule. 2/6
Meanwhile, we are SCRAMBLING as mentors to try and find a way to assist with parking fees for our trainees as a stop-gap, but efforts are blocked at every turn. This includes asking the NIH if we can use grant money to pay for parking. 3/6
Read 6 tweets
Ian Seiple Profile picture
Jul 31, 2020
A twisting journey of stereochemical confusion, structural reassignments, and inactive "antibiotics." Read our full article on the lankacidins, out now in @J_A_C_S ! This was truly an epic journey. Way to go Lingchao, Yanmin, and Seul Ki! dx.doi.org/10.1021/jacs.0… Image
The story starts with the structural reassignment of the only non-macrocyclic member of the class: 2,18-seco-lankacidinol B. We had to make all diastereomers of the lactone ring to find the right one! For the original story, see: dx.doi.org/10.1002/anie.2….
The next chapter contains one of the most hindered Tsuji–Trost reactions I've ever encountered, and it's a macrocyclization! This is followed by a late-stage, C–H amination to install the pyruvamide sidechain. Yanmin was the champion of this very exciting chemistry.
Read 6 tweets
Ian Seiple Profile picture
Jul 9, 2020
Is chemistry authorship gender-balanced? @adamcotton92 wrote a web scraper to mine PubMed for authors' names and countries, cross-referenced with a gender API for 15 journals in the last 16 years. We just put this work on @biorxivpreprint. Thread 1/

doi.org/10.1101/2020.0…
First and corresponding authors were predominantly male in all journals. First author ratios were closer to balanced than corresponding author ratios. 2/ ImageImage
Over the past 16 years, there is little to no improvement in gender ratios for chemistry journals. This was similar for med chem, chem bio, and NCS journals. 3/ ImageImage
Read 7 tweets
Ian Seiple Profile picture
Jun 4, 2020
Peaceful protests are powerful. But to say that peaceful, 'lawful' protests are the ONLY appropriate responses to the oppression and murder of black people is myopic and historically ignorant. 1/
Note how they make protests illegal when it is more convenient for them. It's as easy as implementing a curfew. Then they can use 'unlawful activity' as the justification for violence. Just like they do when they commit murder. 2/
Do you think that the murderers of George Floyd would have had their charges upgraded without the massive showing of civil disobedience that has occurred over the past week? 3/
Read 4 tweets
Ian Seiple Profile picture
May 17, 2019
Tweeps! Incoming rant. "Chemicals" can be very scary. You should be afraid of some chemicals. Other chemicals, like water, you should be less afraid of. But even water has an toxic dose. Terminology matters. Dose matters. I strive to be precise and not promote chemophobia 1/4
"The distinction between natural and synthetic chemicals is not merely ambiguous, it is non-existent." Check out some of the ingredients in a banana, listed in this article: aeon.co/ideas/chemopho… 2/4
Of course nothing is simple. Several synthetic chemicals are toxic or contain toxic byproducts that would not be produced naturally. Also, several natural chemicals are more toxic than synthetic chemicals. Natural ≠ safe. Synthetic ≠ unsafe. Chemical ≠ dangerous. 3/4
Read 4 tweets

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