Aaron Richterman, MD Profile picture
Aug 22, 2020 10 tweets 4 min read Read on X
Antiretroviral therapy is not enough —
background and findings from our new paper in OFID:

with @LeandreFernet @drdrtsai @drlouiseivers
academic.oup.com/ofid/article/7…
2/ Annual deaths from HIV have decreased by 50% since peaking in 2006, mostly because of expansion in access to antiretroviral therapy

But huge disparities remain – HIV is the leading cause of death in Sub-Saharan Africa, & the 9th leading cause of death in low-income countries Image
3/ In 2014 UNAIDS released a Fast Track plan w the goal of ending HIV as a public health threat & reducing HIV deaths by 90% by 2030

The primary focus of this plan is clinical services expansion & universal ART. In our study we ask – is this enough?

unaids.org/en/resources/d…
4/We followed 464 ppl living w HIV in rural Haiti for a median of ~6 years. They were already receiving ART at enrollment (median of 11 months on rx) & cared for at 1 of 3 @PIH health centers

The median age at study entry was 38, there was <10% LTFU, and 25% died during f/u Image
5/ The concurrent findings of high mortality, high clinical retention, & high levels of ART adherence suggest that regular clinical follow-up and provision of ART are insufficient to prevent poor outcomes in impoverished settings
6/ Despite a clinical model that includes an understanding of patients’ social circumstances, community health workers, and some material support, relative impoverishment remained 1 of the most important factors a/w subsequent risk of death in multivariable analyses Image
7/ These findings suggest that social protection and poverty reduction programs, particularly those targeting households w the worst levels of deprivation, may be important components of mortality reduction for people with HIV already receiving ART.
8/Maybe that seems obvious. UNAIDS even has a whole report on the importance of social protection - unaids.org/en/resources/d…

But this reality is not reflected in global funding trends for HIV programs

Here's one example -
/9
On the left, the number of people with HIV receiving ART in Haiti
On the right, PEPFAR funding for social support services in HIV programs
You do the math

The contraction of social support funding is obvious when hearing the lived experience of rural Haitians w HIV ImageImage
10/ Many more details in our paper. I hope you'll read it.
academic.oup.com/ofid/article/7…

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More from @AaronRichterman

May 31, 2023
Over 100 governments in low- and middle-income countries have introduced anti-poverty cash transfer programs over the last 3 decades

In new research, we examined the effects of these initiatives on the ultimate health outcome — mortality

Published today in @Nature /1 Image
We used >80 national surveys in 37 low- and middle-income countries to create longitudinal survival datasets for 4 million adults & 3 million children 2000-2019

About 1/2 the countries started cash transfer programs, & 1/2 the programs were unconditional (no strings attached) /2 Image
We used difference-in-difference models to show these programs led to a 20% reduction in mortality for women, and an 8% reduction in risk of death for children under 5
/3 Image
Read 8 tweets
Nov 16, 2021
New pre-print from @EricMeyerowitz and me reviewing loads of new Delta transmission data.

One area we cover — updates on vaccines' effects on transmission in the Delta era 🧵 1/24

papers.ssrn.com/sol3/papers.cf…
First, to review, vaccines can provide:
-direct protection (reduction in infx/disease among vaccinated ppl)
-indirect protection (reduction in infection among all community members through ⬇️ transmission)
/2

nature.com/articles/s4157…
Indirect protection can be generated by
1) ⬇️ risk of infection (if person not infected, cannot transmit)
2) ⬇️ infectiousness of vaccinated person w infection

Prior to delta, 1) + 2) = substantial transmission reduction of 75%+. Our pre-delta review:
/3

academic.oup.com/ofid/advance-a…
Read 24 tweets
Aug 24, 2021
As @mugecevik points out, despite the recent proliferation of vaccine studies using routinely collected testing data, the majority of these cannot be reliably be used to estimate VE vs all infections because they do not use systematic testing and/or control for confounding.
Vaccine protection against all infections is one important way (of several) that vaccines reduce transmission (discussed👇). Here is an updated table of high-quality studies assessing VE against infection, including just 3 from the delta era at the bottom
academic.oup.com/ofid/advance-a…
When using regular (or cross-sectional) systematic testing to estimate VE, you are really measuring VE against a composite of infection and duration of PCR-positivity, as highlighted recently by @dylanhmorris.
Fascinating discussion of these methods here sciencedirect.com/science/articl…
Read 4 tweets
Aug 11, 2021
This 👇claim arises principally from Israeli data (which is unpublished in any form so will withhold judgment) and from the UK REACT 1 study, rounds 12 & 13. But... is the REACT 1 data likely to be solely explained by delta? 🧵
(study link spiral.imperial.ac.uk/handle/10044/1…)
This is the table in question. You can see VE of a combination of AZ/MRNA vs symptomatic infection was 83% (19-97%) in round 12, but only 59% (23-78%) in round 13. The concern of course is that this drop in VE is due to delta, which had completely taken over by round 13 /2
However, while 100% of the isolates identified in round 13 were delta, 80% in round 12 were also delta (20% were alpha). Any effect of delta on VE should have been partially seen in round 12. /3
Read 7 tweets
Jul 31, 2021
The question at hand: what is the relative transmission potential of a vaccinated person who becomes infected with delta? This 👇new report from Singapore is much more informative on this question than the CT data released so far from Ptown and Wisconsin.
medrxiv.org/content/10.110…
First, importantly, reducing transmission potential of a person who becomes infected is only one component on the transmission reduction effect of the vaccines. The other: reducing the likelihood of becoming infected in the first place. We discuss here👇
academic.oup.com/ofid/advance-a…
We still await definitive evidence from systematic sampling on the ? of overall infection risk reduction with vaccination, but w strong protection vs symptomatic disease, expect that there will still be substantial protection (50+%) vs overall infection
nejm.org/doi/full/10.10…
Read 10 tweets
Jan 12, 2021
Interesting poll. Selection/response bias aside, majority picked a low probability, but 40% still thought there was 10+% prob that vaccines will not substantially prevent transmission. This is why I have become convinced this concern is highly unlikely (borderline implausible) 🧵
1. Data from screening PCR at the time of the 2nd moderna mrna vaccine, showing reductions in asymptomatic PCR positivity. This is before the 2nd dose and if anything will underestimate effect. Will have additional confirmation from unblinding pcr and ab

2. Data from AZ vaccine chadox study is a mess, but they did weekly PCR screening and points in the same direction.
thelancet.com/action/showPdf… Image
Read 27 tweets

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