1/ Crotty Lab member of the week: Yu (Alex) Kato
Alex led the work just published in @ImmunityCP on the multifaceted ways antigen valency affects B cell responses in vivo. That study is important for vaccine immunology, connecting vaccine designs to immunological rules.
2/ He used two photo intravital microscopy, custom engineered proteins, a variety of in vivo models manipulating antigen-specific B cells and CD4 T cells, and all kinds of flow cytometry to figure out this interesting and important puzzle. All told, it was almost 4 years of work!
3/ Alex has also been deeply involved in fantastically successful collaborations with Darrell Irvine's lab at MIT, including a novel vaccine delivery / adjuvant study in @NatureMedicine this year.
4/ Alex came to the lab from Melbourne, Australia, and he recently got married on a trip back in Melbourne. He’s a great member of the lab, and wonderful at mentoring new lab members. Also, he loves food, so if you need a favor in the lab you just have to offer him a treat. 😂😜
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Our new paper is out showing T cell responses to the Novavax vaccine, studying Novavax vaccine clinical trial participants, led by the outstanding Dr. @CModerbacher! With a nice commentary article by @PC_immuno . 🧵
The brand newly approved COVID boosters are going to work well. They won’t be a game changer—won’t prevent all infections—but are the best booster option and will provide a lot of protection.
It’s the immunity you want heading into the Fall and winter.
The Omicron booster vaxs are clearly safe. Billions of Covid mRNA vax doses have been given, with excellent safety. Regarding the new “bivalent” boosters, there was a 2021 bivalent COVID booster vax human trial…
Wonderful workshop on Vaccine Durability questions today and yesterday with NIAID. Thanks to my session co-chair @TheBcellArtist, and the awesome panelists. There was intensive and wonderful discussion, and we did make several recommendations 👇🏼
The awesome panelists were @deeptabhattacha@KingLabIPD, Rama Amara, Kanta Subbarao, and Chris Chiu (are they on Twitter?)
The rapid fire recommendations at the end of the discussion:
What kind of studies that would bring us closer to addressing some of the knowledge gaps in engineering durable vaccine immune responses?
We provided the 2x Novavax immunized donor samples, which we extensively compared to mRNA and J&J vaccines for immune memory antibodies, CD4 T cells, CD8 T cells, and memory B cells in a recent paper sciencedirect.com/science/articl…
And it is good to see a new preprint from Penny Moore and colleagues with similar Novavax Omicron data.
What parts of the immune system are protecting you against COVID? Immunology is complicated, so here's a graphic to try and explain it.
Layered defenses against SARS-CoV-2, or the “Swiss cheese” model of immunity.
Multiple types of adaptive immunity with diverse mechanisms likely provide layers of defense against COVID-19. Conceptually, these are like a “Swiss cheese model”: even though each layer is imperfect, together they keep the pathogen from breaching all layers of defense.
The graphic was inspired by the fantastic masking and public health layered defenses Swiss cheese model of @MackayIM.