1. It is important to include primary adrenal insufficiency in the differential diagnosis for significant hyponatraemia even with the absence of hyperkalaemia.
2. Hypo-osmolar hyponatraemia with urine osmolality greater than serum osmolality and urinary sodium excretion >20 mmol/L, typically seen in syndrome of inappropriate antidiuretic hormone (SIADH), can also be seen in adrenal insufficiency, due to increased vasopressin secretion.
3. Ketonuria is seen in patients with hyponatraemia secondary to adrenal insufficiency, not SIADH. The urine ketone test is an easy point-of-care test to differentiate between these two causes of hyponatraemia.
4. Gingival hyperpigmentation is an important physical finding to look for in Addison's disease, even in the absence of obvious hyperpigmentation of sun-exposed skin. ncbi.nlm.nih.gov/pmc/articles/P…
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Hematogenous dissemination then can occur typically 4 to 10 weeks later, giving rise to secondary syphilis. <40% of pts w/ syphilis have primary syphilis diagnosed. These “Secondary” lesions last for several weeks before spontaneously resolving. Coined “early, latent infection”
What does late infection mean? When syphilitic lesions recur after 1 year from the initial eruption, or seropositivity is detected more than 1 year after the initial eruption, it is termed late latent syphilis.
Some optics neuritis pearls in a short #Medtweetorial 🧵…. We all know that optic neuritis is frequently associated with multiple sclerosis (MS). But optic nerve inflammation can exist from autoimmunity, infection, granulomatous disease, paraneoplastic disorders, & demyelination
Classical ON from MS is unilateral, moderate, painful color vision loss with an afferent pupillary defect & normal fundus examination.
In those with ON, 95% of patients showed unilateral vision loss & 92% had associated retroorbital pain that frequently worsened w/ eye movement.
If you have not listened to the @CuriousClinPod most recent podcast (Episode 10: Why does metronidazole treat both bacterial and parasitic infections?) then I suggest you tune in.
I'll summarize their show notes here in short #medtweetorial
First a question:
Was metronidazole first used as an antibiotic or as an antiparasitic?
If you guessed antiparasitic, then you would be correct!
It was developed in the 1950s to treat the parasite trichomonas & then was used in the 1960s to treat other parasitic infections, like giardia and amoebiasis.
A 31-year-old M born and raised in Brazil w/ no PMH presented with a 3 mon history of worsening DOE, orthopnea, 7kg weight loss, abdominal distention, dry cough, and syncope
An interesting fact from @3owllearning : Depending on the clinical problems, the studies of disease probability for differential diagnosis often show 10 - 25% of cases are unexplained, even after careful examination and testing.