1/11 Why is it important to account for race and ethnicity when working with a genetic disorder, infectious disease, pharmaceuticals, or therapeutics? B/c genetics determine our biochemical response. Here is why this is important.
#COVID19 #JAMA #Medicalscience #clinicaltrials
2/11 People are losing their minds on this #JAMA article calling it racist & not scientific because it uses a "social construct term"-race in place of ethnicity. An overwhelming number of comments are supposed medical pros who forgot how to be objective...
3/11 Sickle Cell inheritance is carried by ~44 million people, and expressed in ~5 million around the globe. It's autosomal recessive, a non sex chromosome, w/ both parents carrying/expressing the disorder genotypically & passing it on. It affects only those of African descent.
4/11 Sickle Cell Disease does confer protections against Malaria in folks w/ the SC trait & outright genetic expression. This doesn't affect white, Asian, or Latino people unless both parents are of African descent & hetero-recessive. A recent review:
pnas.org/content/115/28…
5/11 We see diseases & disorders like this that pop up in various populations based on region, skin color (see my tweet on VitD & #COVID19 /immunity in the black community), ethnicity, & even among genders. The latter, actual biological gender, being crucial in research.
6/11 Until 1994 the FDA didn't allow women of childbearing potential to participate in medical research (or many women for that matter), & racial minorities were few as well. What changed? We recognized that molecules react differently based on gender:
ncbi.nlm.nih.gov/pmc/articles/P…
7/11 This change allowed us to finely tune applications of treatments with a molecule/drug in men & women, observing how it reacts differently based on the race, ethnicity, or geographic origin of the participant. In a way translational research began it's branch...
8/11 One of the most basic things you'll see when you look at #NHANES deidentified datasets & that we see when we do our data cleaning of blinded patients is age, gender, geo origin, & participant ID that will link to deidentified data w/in data collection systems.
9/11 Linking of a subject ID with the de-IDed info & study biomarkers, samples, & data while on a trial allows us researchers to analyze the data & determine if there is a difference in molecule efficacy in treatment, while evaluating outcomes post treatment.
10/11 Accounting for biological differences in gender (there are only 2 with the occasional genetic syndrome) & race/ethnicity allows us to better understand disease disparities across populations, resulting in more effective treatments tailored to those individuals.
11/11 These responses are pure insanity, & the radical SJW ideologies that have infiltrated medicine are why I decided no to continue pursuing med school & went into research. These regressives are a disservice to their patients in the name of being virtuous and an ally...
@gummibear737 I don't know if you'll find this breakdown in the perceived faux racism in medicine/Covid-19 treatment helpful in our fight against Scientism.

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More from @JortsAndCrocs

24 Jun
There's a lot of chatter regarding the impact that state reopenings vs #BLM/#Antifa protests, riots, etc have had on the #COVID numbers for the US. So here's a thread of data.

Blue arrow= phase 1 initiation for many states
Red arrow= initial protests/riots/crowds, etc Image
The boxes represent the respective time frame in which we would expect to see a spike in the DAILY reported cases, not necessarily deaths. While there is correlation between progressive phased openings in many states & increasing cases, these do spike significantly post protests.
We cannot, with scientific integrity, attribute causation to ONLY ONE of these events as the media tries to do (and politicians for that matter), but rather that they both contribute to increased cases simply due to exposure. Exposure is not a bad thing, and #herdimmunity is real
Read 7 tweets

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