three short chapters on gastrointestinal hypo-motility in critical care.
๐Ÿ’ฃthis topic often gets *ignored* until there's a serious complication
๐Ÿ’ฃearly attention to motility can avoid iatrogenesis & facilitate recovery...
(thread #1/4)
ICU gastroparesis
๐Ÿคฎ manifests as tube feed intolerance (but don't assume that feeding intolerance = gastroparesis!)
๐Ÿคฎ a post-pyloric feeding tube can treat this nicely. otherwise erythromycin +/- metoclopramide
๐Ÿคฎ treat this- don't just watch/wait (#2/4)
emcrit.org/ibcc/gastroparโ€ฆ
ICU ileus
๐Ÿคฎprevention is key- avoid opioids, early enteral nutrition, early mobility๐Ÿƒ
๐ŸคฎNG drainage *only* if needed for symptomatic relief
๐Ÿคฎprokinetic meds don't work, but *oral* naloxone might help among patients on significant opioid doses (#3/4)
emcrit.org/ibcc/ileus/ Image
colonic pseudoobstruction (a.k.a. Oglivie's syndrome)
๐Ÿ’ฉ progressive dilation of the colon with risk of perforation
๐Ÿ’ฉ mainstay of therapy is IV neostigmine
๐Ÿ’ฉ get comfortable treating this - early neostigmine may prevent progression (#4/4)
emcrit.org/ibcc/oglivie/ ImageImage

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More from @PulmCrit

Dec 17, 2023
how to place a consult: you MUST understand the five stages of consultant grief.

once you can understand this painful and natural process, requesting consults will make a LOT more sense

buckle up, it can be a little roughโ€ฆ

๐Ÿงต 1/6โ€ฆ
stage 1: denial

- You dont need a consult.
- You called the wrong service.
- 18 years old? consult pediatrics
- Iโ€™m not actually on call now
- Everythingโ€™s fine, just walk it offโ€ฆ
stage 2: anger

- you should have consulted us earlier/later
- you should have checked this test before calling us
- youโ€™re a terrible doctor/student/human being
Read 6 tweets
Nov 24, 2023
Iโ€™m gonna myth-bust this myth-busting slide on the use of bicarb.

the slide says to use bicarb for hyperkalemia โ€œonly in cardiac arrest??โ€

there is evidence on this and I think itโ€™s possible to make a more accurate statementโ€ฆ ๐Ÿงต
the problem is that people ask the wrong question: โ€œdoes bicarb work for hyperkalemiaโ€

bad question.

any systemic analysis based on this question is a failure.

this would be like asking โ€œdoes sodium chloride work for cerebral edemaโ€

well, it dependsโ€ฆ on the concentration!
hypertonic sodium bicarb (in the USA = 50 mEq in 50 cc) doesnโ€™t work for hyperkalemia

this has been tested in RCTs and it doesnt work

hypertonic fluids pull fluid & K out of cells (โ€œsolute dragโ€) and this prevents hypertonic bicarb from working for hyperkalemia
Read 5 tweets
Oct 27, 2022
another haloperidol thread ๐Ÿ˜ƒ

this fresh pro-con debate on the use of IV haloperidol is important reading (even for folks not working in the emergency department).

(is there any neuroactive medication that people don't have passionate opinions about? ๐Ÿคฃ) ImageImageImageImage
from the ICU perspective, the recent AID-ICU trial shows that IV haloperidol is safe in the ICU.

of course, this *assumes* that it's used wisely (with attention to electrolytes and QT)

(hint: when in doubt, give IV magnesium along with the haloperidol)

as @SkylerLentz et al. discuss, haloperidol is generally preferred over benzodiazepines for agitation in the ICU.

as a general rule of thumb, *any* time you're tempted to use benzodiazepines in the ICU - consider whether haloperidol might be a better option.

benzos are a trap:
Read 5 tweets
Oct 26, 2022
hot take on the AID-ICU trial of haloperidol for management of delirium in ICU ๐Ÿ”ฅ

this is the largest MC-RCT to date on haloperidol for treatment of delirium (in comparison, MINDS enrolled 192 patients in the haloperidol group).

nejm.org/doi/full/10.10โ€ฆ
55% of patients had hyperactive delirium.

this is much better than MINDS (which contained ~90% hypoactive), but probably still not ideal.

(at this point, does anyone actually think that haloperidol helps with hypoactive delirium ??)
other than dilution of the patient population by patients with hypoactive delirium (who are unlikely to benefit & might conceivably be harmed by over-sedation), the methodology seems pretty solid.
Read 11 tweets
Aug 17, 2022
I think this paper by the Nielsen group on the use of CT scans to neuroprognosticate after cardiac arrest may be a game-changer.

But it will take a few tweets to explain why... ๐Ÿงต

pubmed.ncbi.nlm.nih.gov/35931271/
prognostication after cardiac arrest involves a structured series of tests performed over time.

this may vary a bit between patients and institutions.

most often, decisions center around the trifecta:
๐Ÿ”บserial clinical examination
๐Ÿ”บcontinuous EEG
๐Ÿ”บMRI
MRI is the weak link:

๐Ÿ–‡๏ธ least robust evidence
๐Ÿ–‡๏ธ interpretation is subjective
๐Ÿ–‡๏ธ logistically challenging (eg pacemaker)

MRI can help if there is *no* anoxia, or if there is an unexpected *alternative* dx.

MRI isn't great at sorting out bad anoxia from moderate anoxia.
Read 8 tweets
Aug 15, 2022
I think it's time for a difficult discussion, folks.

Let's talk about CSF lactate ๐Ÿซฃ

CSF lactate has been shown to be *superior* to traditional CSF studies in sorting out viral vs. bacterial meningitis in several studies & meta-analyses...
a subset of patients with viral meningitis will initially have a *neutrophilic* pleocytosis.

this can lead to unnecessary admissions & antibiotics

some patients are subjected to repeat LPs ๐Ÿ˜ฉ

a low CSF lactate could avoid all of this, allowing patients to go home from the ED
CSF lactate measurement is recommended in guidelines from the United Kingdom, Europe, and France.

(it's not recommended in the ID society of America guidelines, but they're from *2004* and require revisions)
Read 6 tweets

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