'Rogue' Chinese Virologist Joins Twitter, Publishes "Smoking Gun" Evidence COVID-19 Created In Lab zerohedge.com/medical/rogue-…
Intriguingly, the RBM of SARS-CoV-2 resembles the RBM of SARS Spike. Although this is not an exact “copy and paste”, careful examination of the Spike-hACE2 structures 37, 38 reveals that all residues essential for either hACE2 binding or protein are “kept”
zerohedge.com/medical/rogue-… Image
Most of these essential residues are precisely preserved, including those involved in disulfide bond formation (C467, C474) and electrostatic interactions (R444, E452, R453, D454), which are pivotal for the structural integrity of the RBM (Figure 3C and 4)
zerohedge.com/medical/rogue-… ImageImage
"The evidence shows that SARS-CoV-2 should be a laboratory product created by using bat coronaviruses ZC45 and/or ZXC21 as a template and/or backbone. Building upon the evidence, we further postulate it's easy to create SARS-CoV-2 would take only 6 months
Here is the extended punchline:

"The receptor-binding motif of SARS-CoV-2 Spike cannot be born from nature and has been created through genetic engineering.
NOT bats:

ACE2 proteins in bats are not homologous enough to hACE2 and therefore the adaption would not be able to yield an RBM sequence

This animal reservoir also could not be humans as the ZC45/ZXC21-like coronavirus would not be able to infect humans
In 2008, Dr. Zhengli Shi’s Wuhan lab swapped a SARS RBM into the Spike proteins of several SARS-like bat coronaviruses after introducing a restriction site into a codon-optimized spike gene (Figure 5C).
zerohedge.com/medical/rogue-… Image
"The RBM of was swapped into the receptor-binding domain (RBD) of SARSCoV, resulting in a chimeric RBD fully functional in binding hACE2 (Figure 5C). Strikingly the RBM segments almost exactly the RBM defined by the positions of the EcoRI and BstEII sites 
zerohedge.com/medical/rogue-… Image
"Noteworthy that the corresponding author of this recent publication, Dr. Fang Li, has been an active collaborator of Wuhan's Dr. Zhengli Shi since 2010

Dr. Li was the first person to have structurally elucidated the binding between SARS-CoV RBD and hACE2
"The striking finding of EcoRI and BstEII restriction sites at either end of the RBM, and the fact that the same RBM region has been swapped both by Dr. Shi and by her long-term collaborator, respectively, using restriction enzyme digestion methods.
zerohedge.com/medical/rogue-… Image
"The Chinese scientists then presciently tried to cover their tracks:

Although it may be convenient to copy the exact sequence of SARS RBM, it would be too clear a sign of artificial design and manipulation.
"All of the crucial residues (residues labeled with red sticks in Figure 4, which are the same residues shown in sticks in Figure 3C) should have been “kept” to not disrupt hACE2-binding and may even strengthen

Thus the virus was weaponized and enchanced
zerohedge.com/medical/rogue-… ImageImageImage
"infamous furin-cleavage site:

... a close examination of the nucleotide sequence of the furin-cleavage site in SARS-CoV-2 spike has revealed that the two consecutive Arg residues within the inserted sequence (- PRRA-) are both coded by the rare codon CGG
zerohedge.com/medical/rogue-… Image
"In fact, this CGGCGG arrangement is the only instance found in the SARS-CoV-2 genome where this rare codon is used in tandem. This observation strongly suggests that this furin-cleavage site should be a result of genetic engineering.
zerohedge.com/medical/rogue-… Image
"There, the fragmentation pattern resulted from FauI digestion could be used to monitor the preservation of the furin-cleavage site in Spike as this furin-cleavage site is prone to deletions in vitro.
zerohedge.com/medical/rogue-… Image
"RT-PCR on the spike gene of the recovered viruses from cell cultures or laboratory animals could be carried out & subjected to FauI digestion

Changes to furin-cleavage site would then yield distinct patterns, allowing tracking of the viruses of interest
zerohedge.com/medical/rogue-… Image
"To boost the "enhancement of the infectivity and pathogenicity of the laboratory-made coronavirus":

The furin-cleavage site in the SARS-CoV-2 Spike protein was modified to assess and monitor any potential enhancement of the infectivity and pathogenicity.
"Virus created by using ZC45/ZXC21 bat coronavirus(es) as the backbone and/or template. The Spike protein, especially the RBM within it, should have been artificially manipulated, upon which the virus has acquired the ability to bind hACE2 & infect humans.
zerohedge.com/medical/rogue-… Image
"The Spike protein, especially the RBM within it, was manipulated, upon which the virus has acquired the ability to bind hACE2 and infect humans. This is supported by the finding of a unique restriction enzyme digestion site at either end of the RBM
zerohedge.com/medical/rogue-… Image
"An unusual furin-cleavage site introduced & inserted at the S1/S2 junction of the Spike protein increased virulence & pathogenicity.

SARS CoV-2 virus is highly-transmissible, onset-hidden, lethal, sequelae-unclear, & massively disruptive pathogen.
zerohedge.com/medical/rogue-… ImageImageImageImage
A Hong Kong researcher who has published papers with the Wuhan lab has fled to the United States and has written a paper showing how the Wuhan lab created the virus
Reminds me of work that @Baric_Lab & @TheMenacheryLab did - really groundbreaking - should get a Nobel Prize in medicine, how often does your handiwork get to be used to reduce the plant's population by 10-15% as Bill Gates said he was working to achieve.
Question for Dr Li-Meng YAN @LiMengYAN119
Do you think this paper by @HarvardScience @HarvardChanSPH @DanaFarber @Baric_Lab @TheMenacheryLab is related to what you reported in your recent paper is describing Dr Baric's protegee using @NIHDirector funding?
"Dr. Li-Meng Yan, a former researcher at the Hong Kong School of Public Health, posted a paper on the the open-access repository website Zenote, that shows how SARS-CoV-2 could be “conveniently created” in a laboratory setting in six months @LiMengYAN119

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More from @ThomasConnors

2 Apr
Do you find this to be credible or does it sound like a whole lot of half-persuasive not very scientific explanations? sciencenews.org/article/corona…
Ahhh my bad, turns out these are the authors of the British Nature study purporting that #COVID19 #coronavirus @TuckerCarlson was natural. Of course it was, it naturally evolved using caged ferrets repeatedly exposed to bat & pangolin virus see: @jjcouey
See the "See More" on the above video for bibleography. If you want more extensive text with footnotes and citations please read this from @Harvard2H : harvardtothebighouse.com/2020/03/19/chi…
Read 8 tweets
31 Mar
"Chinese government researchers isolated more than 2,000 animal viruses, including deadly bat coronaviruses, and carried out scientific work on them just three miles from a wild animal market identified as the epicenter of the COVID-19 pandemic."
"Several Chinese state media outlets in recent months touted the virus research and lionized in particular a key researcher in Wuhan, Tian Junhua, as a leader in bat virus work." washingtontimes.com/news/2020/mar/…
"Reports of the extensive Chinese research on bat viruses likely will fuel more calls for Beijing to make public what it knows about such work
“This is one of the worst cover-ups in human history...world facing global pandemic,” Rep. Michael T. McCaul R-TX washingtontimes.com/news/2020/mar/…
Read 21 tweets

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