Here, then, is a story from Covid Britain. It will be a longish thread.
It starts with this story I wrote for The Guardian on the UK's readiness for the autumn/winter: theguardian.com/commentisfree/…
My instinct screams that the answer to the title question is: "probably not much". But I'm determined to avoid kneejerk cynicism, and to listen to what I'm told by folks who know. And the answers are mixed, but one thing gives me a little bit of hope...
...which is that it sounds like the testing situation, while still having a way to go before being good, is at least not too bad. We have quite a lot of capacity, at that stage apparently exceeding the demand. So that's somewhat encouraging.
But even as schools and workers are returning, stories start coming in of people unable to get tests, or being asked to travel hundreds of miles to get one. Households are left in limbo, unable to get tested & not knowing what to do.
Then we hear about Operation Moonshot, the UK government's grand plan to establish a £100 bn mass testing regime perhaps handling up to 10m tests a day by early 2021, using technology still in development. And the general reaction from most experts is: you must be joking.
Much of today I have been completing an article on this for Prospect, to go live tomorrow morning. I haven't minced words (most of the critical ones being other people's who know more than I do). But I have again also wanted to be fair and to hear a range of views.
And again, it is possible to find a few reasons not to be simply reflexively cynical, at least about the principle. One wants, as a writer, at least to do better than say "This shower in charge have yet to demonstrate competence at anything" - even if there's some truth in that.
While I'm writing, I'm interrupted from time to time by a bored youngest daughter, at home from school because she clearly seems to have the cold that's already being going round her class. We are monitoring her state nervously. So far, all classic cold symptoms, not Covid...
But at one point in the early afternoon, she clearly has a bit of a temperature. 37 degrees... 37.5, thereabouts. Then at one point it hits 38 before going down to normal. So what now?
We agonize. The eldest has just been settling into her new year at secondary, and of course will have to stay home if we decide to give the youngest a test. But really, we realize it is the responsible thing to do - even though by now, this evening, she's right as rain.
Well, you know what's coming, don't you? So did I, really:
I see now too how crap the system is even if it was working. There seems to be no option right away to book a test for a child only. Do do we enter her name at the outset? Ours? Anyway, it's a moot point. There are no tests available.
We're very lucky. Having to stay at home is not a problem either for me or my partner. If someone in this position were faced with lost earnings, the need to cancel appointments, to keep large numbers of kids all at home again, and all because you're obeying...
... the letter of the "rules" because of a single temperature reading (no other "suspect" symptoms), I think you could be forgiven for saying, Sod it, she's fine.
Will we be able to get a test? I've no idea.
Should we be generous about the government's ability to deliver Operation Moonshot?
I leave you to decide.
But if anyone feels my article for Prospect tomorrow is unduly harsh, please don't bother telling me so.
And here's the final thing. The folks working to develop tests and ramp up capacity have been working their butts off, all in good faith. I completely respect them, and this situation traduces their efforts.
No, they are not the problem.
Update:
(I mean, not even Inverness now?)
Ah.
Totally right that, amidst this shambles, priority goes to hospital & care workers and those in worst-hit areas. I suspect this means there is effectively very little testing going to happen outside of that. theguardian.com/world/2020/sep…
Yes, I'm very angry. Not for my family - we're not at risk, I'm quite sure of that. But for those who are.
And because those who should have seen this coming apparently did not.
(I don't mean Hancock. I expect nothing useful from him.)
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Nice article by David Krakauer and Chris Kempes about the computational view of living things. I have some initial thoughts... aeon.co/essays/is-life…
Most of all, it feels crucial to maintain a distinction between what evolution does and what living things do. I have no problem with considering organisms as problem-solving - as goal-directed entities, they *must* be. /2
I'm less sure whether it's right to see the evolutionary process as problem-solving, e.g. "Insect wings solve the ‘problem’ of flight". I don't think that's the right framing, not least because it has a strong whiff of teleology. /3
"Dr Simoné said a lot of people are drinking plenty of water however that water is not the same structure as what we have at an intracellular level."
Oh hello again my old friend. dailymail.co.uk/femail/health/…
"'If we can use lemon lime cinnamon clove and Celtic unprocessed sea salt you can actually change the structure of the water so it hydrates,' she said."
God give me strength (and commas).
Like so much quackery, this is vitalized by a tiny shard of truth: water is restructured in the hydration shells of biomolecules, and this matters. "Lemon like cinnamon clove" has nothing to do with that. It just happens. pubs.acs.org/doi/10.1021/cr…
Reading a new biography of Jim Lovelock (of which more at a later date) has sent me back to an exchange I had with Jim in 1993 in the ecological magazine Resurgence. My God, the biography casts that in an interesting light.
A 🧵 /1 resurgence.org/magazine/issue…
My piece was called Myth and Meaning in Gaia, and it set out to explain the version of Gaia theory then current. A little priggishly, I argued that the idea raised some interesting ideas but that the “strong Gaia” view – that the Earth is literally alive – was untestable. /2
As I recall, I was somewhat influenced by Jim Kirchner’s critiques of Gaia, like this one. Kirchner first put forward his challenge at a 1987 Chapman conference of the AGU, instigated by Steve Schneider. That was a big deal,& a big challenge for Jim L. /3 agupubs.onlinelibrary.wiley.com/doi/abs/10.102…
Had a fun argument last night about the machine metaphor in biology. My position is that, while it's fine to use a machine metaphor to describe some parts, like a heart or a flagellar motor, it doesn't work well for a living organism as a whole. The counterargument was...
...that if a machine is an entity in which component parts work together to achieve a goal, we're machines. But my objection is that this is then no longer a metaphor but a redefinition of machines to include us (as well as all kinds of things, like books, that...
... don't seem obviously machine-like). The whole point of a metaphor (here) is that it refers to something familiar to describe the less familiar. If "machine" doesn't refer to a typical image of a machine, the metaphor evaporates - or worse, misleads. Views?
Here goes another thread on why a new paper illustrates an aspect of what I’m loosely calling “the new biology”: an emerging picture of the operational principles of our highly complex molecular and cellular basis. /1
Here’s the paper: /2
(I gather it's best now not to put the links in the first tweet of a thread, because Elon.) nature.com/articles/s4158…
The paper begins with a very nice and apt statement: “The discovery of pervasive transcription and the revelation of the large number of non-coding RNAs (ncRNAs) raised the question of their functionality.” /3
Here’s another thread dissecting an amazing but complex piece of molecular/cell biology. Again, I believe it illustrates some important general principles. (And it’s condensate-free!) Here’s the paper. /1 cell.com/cell-systems/a…
It comes from the lab of Aryeh Warmflash at Rice University, who is at the forefront of decoding the molecular processes that govern the behaviour of pluripotent stem cells. The 1st author is Elena Camacho Aguilar of the Andalusian Center for Developmental Biology in Seville. /2
The question they address is how pluripotent cells in the very early embryo acquire their initial fates, differentiating into more specialized tissues. One of the first stages of differentiation takes pluripotent stem cells (PSCs) to the three tissue types that…. /3