Professor Philip Nolan Profile picture
Sep 18, 2020 11 tweets 3 min read Read on X
It is reasonable to ask: why close restaurants and pubs if there are so few outbreaks associated with those environments? However, this is misreading and misinterpreting the data on outbreaks and clusters. 1/10
If I went out 5 days ago and caught the virus in a restaurant, it will have multiplied silently inside me for 3 days; then I will have started shedding virus, and potentially infecting others, for 2 days; today I become symptomatic, self-isolate, and get a test. 2/10
Public health only ask me about my contacts for the 48 hours before I developed symptoms. They don’t need to know where I got the virus; that happened 5 days ago. They want to know where the virus is going, who I might have infected, and prevent onward transmission. 3/10
My contacts are tested, and unfortunately two of my family are infected. It’s now a household outbreak, and I am a case of community transmission. Even though I got it in a restaurant and brought it home. 4/10
We would like to go back and find out where people are getting the virus, but we don’t have the time or resources to pursue this academic exercise. 5/10
We have lots of international evidence from better resourced systems on how the virus transmits: we know that social settings, including bars and restaurants, drive community transmission. 6/10
We know that in Dublin at least one in three cases are community transmission. Where is this happening? Wherever we mix socially: our houses, gyms, bars, restaurants. Sadly, unless we stop mixing in these settings, we know the disease will spiral out of control. 7/10
This is really difficult. Restaurant and gastropub owners have worked very hard to minimize the risk of transmission. Their livelihoods and our safety are at stake, and their work allows us to socialize and enjoy ourselves safely when the level of the virus is low. 8/10
However, the level of the virus is rising again rapidly, and we have to radically reduce mixing between households. 9/10
If we don’t, this virus will kill some of us, saturate our health system, close schools, and create a bigger shock to our economy. It’s devastating for those businesses affected, but we must act now, while targeted measures might still get the virus back under control. 10/10
...for clarity on above, of course our colleagues in public health would track down the source if they had the resources to do so, but they don’t, and must prioritise the management of cases, outbreaks and onward transmission.

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More from @PhilipNolan_SFI

Dec 18, 2021
Omicron will be a very significant challenge, but we are acting early, quickly and comprehensively. If we take a booster vaccine when offered, significantly limit contacts, mitigate risk, self-isolate if symptomatic and restrict movements if a contact, we can get through it. 1/22
The purpose of the formal restrictions is to significantly reduce risky social contact, the opportunity for the virus to transmit; they are to reinforce a call to all of us to prioritise our socializing over the coming weeks to a small group of people who matter most to us. 2/22
We already have, by reducing our contacts and adherence to basic public health measures, begun to bring infections and hospitalisations down after a significant surge of the delta variant in early November. This was difficult, but we did it together. 3/22
Read 22 tweets
Nov 21, 2021
Let’s think and act positively. We can, with collective action, control transmission of SARS-CoV-2 again, and relieve the pressure of COVID-19 on our healthcare system. The effective reproduction number is currently estimated at around 1.2 1/12
If we can reduce our close social contacts by 30%, and/or mitigate the risks of those social contacts by 30%, we will have done enough to see the level of infection, case numbers and ultimately hospitalisations decline. 2/12
The more we prioritize and limit our social contacts, and mitigate those risks, the faster things will improve. The rising numbers of people in hospital and ICU are an urgent call to action. 3/12
Read 12 tweets
Nov 17, 2021
The latest modelling of SARS-CoV-2 infection in Ireland shows that we urgently need to reduce transmission if we are to avoid further dangerous increases in cases and hospitalisations. Stay home with symptoms, limit contacts, use basic mitigations. 1/20
The current surge in disease began soon after the relaxation of measures on 20 Sept 2021, and accelerated from 22 Oct 2021 through the mid-term break. The increase in effective social contact is the primary driver, along with waning vaccine immunity. 2/20
Vaccines are very effective, but over time the immune defence against simple infection wanes. Fortunately, protection from severe disease is well maintained. The waning immunity means that increasing social contact causes a large and increasing force of infection. 3/20
Read 20 tweets
Oct 16, 2021
Why are SARS-Cov-2 infections increasing in Ireland? It’s complex, but most likely a mix of increased mobility and social contact since late September, slippage on transmission prevention measures, and more social mixing indoors. 1/16
We had high but stable levels of infection through September 2021, but this was created by a very dynamic and delicate balance between increasing vaccine protection suppressing the virus, and increasing social contact creating opportunities for the virus to spread. 2/16
We started at a disadvantage compared to most of Western Europe. We were hit by a very large wave of delta infections in July, with most of the population under 50 not yet vaccinated, driving daily cases from 300 to 1800 per day between June and August. 3/16
Read 16 tweets
Sep 22, 2021
There is no evidence that the reopening of schools has led to an increase in transmission or levels of infection amongst school-going children or more widely across the population. 1/14
The level of infection in children and adolescents had increased in the course of the summer as the delta variant increased the rate of transmission. 2/14
This had stabilized at a high level in children aged 12 and under, and decreased markedly in 13-18 year olds, as vaccination reduced incidence in adults and adolescents, and began to reduce the probability of children becoming infected. 3/14
Read 14 tweets
Sep 12, 2021
A lot of commentary saying that most or all schoolchildren will be infected with SARS-CoV-2 in the coming months, based on an uncritical reading of this modelling study. It is highly unlikely that the scenario modelled will happen in the real world. 1/12

medrxiv.org/content/10.110…
First, it’s not plausible. In the 12 weeks after primary schools reopened in March 2021 we detected 5,279 cases in children aged 5-12 years, or just under 1% of the population. The vast majority of these infections were transmitted in the community, not in school. 2/12
Even if delta is 50% more transmissible than alpha, it’s a long way from 1% of the population to 50-75% of the population becoming infected in 12 weeks; note also that most transmission was in the community, and the majority of the community is now vaccinated. 3/12
Read 12 tweets

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