Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
ice9 Profile picture
@__ice9
Sep 18, 2020 • 20 tweets • 9 min read • Read on X
... RaTG13 and other bat CoVs from the same deadly Yunnan cave fitting the stated inclusion rule for use in the hACE2-optimized recombination grant, SARS-CoV-2 indeed binding human ACE2 hundreds of times better than SARS-CoV, winter in a city outside known ranges of such bats,
... fully synthetic recombination techniques and full genome data already available, prior use of non-SARS-CoV backbones and a clear justification for doing so again, a demonstrated history of refusing to disclose sequences and lying about both culture work and deadly pathogens,
... ground zero a human superspreader event at a market down the highway from the WIV CAS office and a few hundred meters from the Wuhan CDCP, *right around a biosafety conference with staff from the BSL3/4 lab* known to be infecting animals at the time.

Image
One was likely sick and simply didn't know it yet, and that is all that would have been required.

The furin site facilitates pre-symptomatic spread, contrary to SARS-CoV which lacked one. It confused the WHO and national authorities. The lab likely didn't quarantine for it.
Removed one post, rephrased:

Multiple demonstrable lies from Shi.

Appointment of Daszak himself to lead the Lancet commission on COVID-19 origins (absurd conflict of interest), rapid statement against (his own) lab involvement.

covid19commission.org/peter-daszak

telegraph.co.uk/global-health/… ImageImageImageImage
Also:

A lab accident in China caused a different respiratory viral pandemic in 1977, namely H1N1 influenza.

nationalpost.com/news/a-brief-t…

archive.fo/wip/Buupf

Other known lab escapes:
- smallpox (3 times)
- SARS (6 times!)
- VEE
- FMD

Article from 2014, with excellent sourcing. ImageImageImageImage
Daszak confirmed WIV bat CoV work was only at BSL-3, or in some cases BSL-2, not BSL-4.

Just for the record, I have personally worked at BSL-2. Precautions are much less severe than e.g. COVID-19 wards.

Stamps:

tweetstamp.org/12664816163036…

tweetstamp.org/12591023808697…

In blockchain. ImageImage
Discussions of greater binding affinity for human ACE2 by SARS-CoV-2 vs. SARS-CoV:

The effect is magnified by the lack of endosomal entry dependence for SARS-CoV-2, as binding affinities for both fall at endosomal pH:



Obviously it is also another viable entry route, but this is tangential from the claim of greater hACE2 affinity.
All necessary techniques were available and in use by relevant parties years in advance.



This swapping of Spike proteins and even small manually selected mutations has extensive precedent within the SARS-family CoV ecological research community.
Congressional representatives noted concerns raised by the EcoHealth bat coronavirus grant work ongoing in Wuhan as well.



Putting a more permanent halt to the ironic risks of gain-of-function research should be a bipartisan issue.
Also, recall early Chinese samples of SARS-CoV-2 isolated from patients in the community were destroyed.

businessinsider.com/china-confirms…

This is consistent with the broader documented pattern of hiding samples and sequence data, and lying about the extent of experiments performed.
Interview with Baric, in which he states as expected that the fully synthetic methods used in his chimeric SARS-like virus work with EcoHealth do not leave any particular genetic signature at all.



Consistent with impressions from his group's papers.
Further confirmation from Shi's group that adult hACE2-expressing ('humanized') mice were available at WIV for SARS-like CoV infection in January.



Independent evidence that the EcoHealth grant work had been well underway, matches Daszak November comment.
Bat CoVs other than SARS-CoV or MERS-CoV specifically (BSL-3) were apparently handled at only BSL-2, including live animal studies.



This raises a greater degree of concern for inadvertent aerosolization, as most activities are permitted on an open bench.
To give a few examples, here are 6 more lab accidents involving SARS-like coronaviruses from just UNC alone.



Splashed cell plates, scattered mouse bedding, dropped mice, multiple mouse bites, etc.

BSL-3. Staff had PAPRs. Less common at BSL-2.
Further evidence for the use of multiple different backbones in the recombinant SARS-like coronavirus grant--

>inserting them into other *CoVs*

Plural, in the exact context of the wildlife CoV sampling and hACE2 targeting work. Image
Another early undisclosed human case of putatively novel bat CoV infection in Yunnan province, apart from the Mojiang miner cases--

Unusual procurement activity for emergency supplies beginning in September 2019 in Wuhan.

Overview of particular hazards related to animal studies with BSL-3 pathogens:

sciencedirect.com/science/articl…

Animal studies tend to be much more hazardous than work conducted solely in vitro. Consider e.g.:

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with ice9

ice9 Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @__ice9

ice9 Profile picture
Mar 7, 2021
Again, the most useful points for a broad audience:

- get vaccine ASAP; prefer mRNA or Novavax; 2 doses far better than 1

- store RCT-validated early treatments: bromhexine-or-ambroxol + nitazoxanide-or-niclosamide, fluvoxamine, ivermectin

- N100 masks

For a medical audience:

- decide what the word "evidence" means:
a) "clinical results with appropriate sample(s) and endpoints"
b) "what huge lumbering institutions claim ex cathedra with no citations"
c) "what gilead et al. claim"
d) "peer best practices"

- take low-risk bets
If in doubt, *ask the patient*.

People have a fundamental right to participate in their own health-- *they already do so 99% of the time anyway*.

'This might help with X; it's a bit less certain; may cause Y side effects; studies say usually well-tolerated; do you want to try?'
Read 4 tweets
ice9 Profile picture
Feb 28, 2021
The continued failure to trial or use ITPP in critical care is an indictment against the regulatory and productive institutions of our supposedly-advanced (increasingly just shorthand for 'gridlocked') economy.

en.wikipedia.org/wiki/Myo-inosi…

It makes blood transport oxygen better.
It costs practically nothing.

Thousands of people already use it for athletic activities.

It has no side effects, is safe at huge doses in animal studies, and has never had a serious adverse event reported in the community ('that's informal' it's post-marketing surveillance..).
The fact that we are jamming tubes down people's throats before giving this, or for that matter even giving cyproheptadine, absolutely disgusts and appalls me.

>Oh that isn't proven

Yes. It. Is.

READ A BOOK; THEY ARE BOTH LITERALLY BASIC PHYSIOLOGY.

Read 5 tweets
ice9 Profile picture
Feb 28, 2021
Efficacy is nowhere near Novavax or the mRNA options (Pfizer/Moderna).

Much like Sinovac/Sinopharm(/CanSino), the tell for this is the headline numbers focusing solely on severe COVID-19 and ignoring mild/moderate cases.
Even for moderate, only 66% effective....

statnews.com/2021/01/29/jj-…

>One hope is that the efficacy of the Johnson & Johnson vaccine could rise if it is given as a two-dose regimen.

Obviously, yes! This is much more promising.
Single-dose frankly seems gimmicky, in a very specific sense:

This is effectively just offloading the debate about whether to halfway-dose existing vaccines to a new vaccine candidate instead-- one that has actually been trialed in this dosing schedule.
Read 5 tweets
ice9 Profile picture
Feb 26, 2021
A couple things about which I would like to be clear, from the now-big account (likely smaller over time):

1) do not ever @/DM to ask where I am or act like I owe you something-- pay me a bitcoin if you want that kind of attention, I know that is pocket change to some of you
2) I have a life outside of COVID-19 and a very, very detailed post history that is approximately two clicks away, depending on your choice of platform access method: search feature, "__ice9 <whatever topic>" papers generally do not become 'out of date' and a result is a result
3) I am frankly a bit bored. The acute disease was obviated months ago by dual entry inhibition. Not my problem if the west ignored it because it came from Iran, or due to statistical illiteracy or vile conflicts of interest (hi Gilead puppets 🎭). Fluvoxamine looks great too.
Read 7 tweets
ice9 Profile picture
Feb 1, 2021
Reminder:

If you test positive for COVID-19 and do not have fluvoxamine on hand, please consider enrolling in this clinical trial.

It's simple, remote, and important. It's a 50% chance to get fluvoxamine.

You can keep using other medications. Delivery is overnight shipping.
You can read the protocol summary here for more details on the trial if desired:

clinicaltrials.gov/ct2/show/NCT04…

My prior post about it is here:

Fluvoxamine was 100% successful in preventing hospitalization in an earlier RCT for use in mild COVID-19 within a few days of onset.

It was also associated with a 100% lower risk of progression to hospitalization in observational study.

Among the best.

Read 4 tweets
ice9 Profile picture
Jan 22, 2021
NAC apparently has antiviral effects vs. SARS-CoV-2.

chemrxiv.org/articles/prepr…

EC50 ~10μM
163g/mol * 10μM = 1.6mg/L
Plasma, as VoD=0.4L/kg

Hittable at 600mg oral q.i.d.:

pubmed.ncbi.nlm.nih.gov/2029805/

link.springer.com/article/10.100…

Unlike for vWF, Spike inhibition by NAC does not need IV.
Note I really do mean 600mg *q.i.d.* (4x/day) if tolerated; short half life. Safe in other studies.

link.springer.com/article/10.100…

Side note: strangely demanding PK study; very rigorous protocol. Hope participants were at least paid well. But they got us a number so I am pleased.
NAC may not have a large impact in monotherapy, given only EC50 is hittable (not EC90 except perhaps IV) and gappiness in plasma concentration peaks even q.i.d. (slightly compensated by permanent nature of damage done to exposed Spike copies).

But it looks like a good addition.
Read 5 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

Send Email!

:(