Crotty lab member of the week is Carolyn Rydyznski Moderbacher, PhD! 1. Carolyn is the lead author of our new COVID-19 immunology paper studying T cell and antibody responses in acute COVID-19 cases. cell.com/cell/fulltext/… @ljiresearch
2. Carolyn wasn’t planning on working on COVID-19, but she had developed excellent multi parameter flow cytometry panels for other human T cell studies, and AIM assays, and I needed her to take the lead on COVID-19 T cell work,
3. so she dropped her other project and has worked full time on COVID-19 for the past 6 months, trying to understand immunity to COVID-19. Culminating in the new paper.
4. Carolyn came to us from Cincinnati, where she did her PhD at Cincinnati Children’s. She’s a big fan of animals, and she knows way more about horses than I ever will. It’s clear that if she could have a horse ranch in the middle of San Diego she would!
5. Carolyn is an excellent scientist and a wonderful team player, and it is people like her who are making a difference in our scientific understanding of this horrible disease. @ljiresearch
• • •
Missing some Tweet in this thread? You can try to
force a refresh
Our new paper is out showing T cell responses to the Novavax vaccine, studying Novavax vaccine clinical trial participants, led by the outstanding Dr. @CModerbacher! With a nice commentary article by @PC_immuno . 🧵
The brand newly approved COVID boosters are going to work well. They won’t be a game changer—won’t prevent all infections—but are the best booster option and will provide a lot of protection.
It’s the immunity you want heading into the Fall and winter.
The Omicron booster vaxs are clearly safe. Billions of Covid mRNA vax doses have been given, with excellent safety. Regarding the new “bivalent” boosters, there was a 2021 bivalent COVID booster vax human trial…
Wonderful workshop on Vaccine Durability questions today and yesterday with NIAID. Thanks to my session co-chair @TheBcellArtist, and the awesome panelists. There was intensive and wonderful discussion, and we did make several recommendations 👇🏼
The awesome panelists were @deeptabhattacha@KingLabIPD, Rama Amara, Kanta Subbarao, and Chris Chiu (are they on Twitter?)
The rapid fire recommendations at the end of the discussion:
What kind of studies that would bring us closer to addressing some of the knowledge gaps in engineering durable vaccine immune responses?
We provided the 2x Novavax immunized donor samples, which we extensively compared to mRNA and J&J vaccines for immune memory antibodies, CD4 T cells, CD8 T cells, and memory B cells in a recent paper sciencedirect.com/science/articl…
And it is good to see a new preprint from Penny Moore and colleagues with similar Novavax Omicron data.
What parts of the immune system are protecting you against COVID? Immunology is complicated, so here's a graphic to try and explain it.
Layered defenses against SARS-CoV-2, or the “Swiss cheese” model of immunity.
Multiple types of adaptive immunity with diverse mechanisms likely provide layers of defense against COVID-19. Conceptually, these are like a “Swiss cheese model”: even though each layer is imperfect, together they keep the pathogen from breaching all layers of defense.
The graphic was inspired by the fantastic masking and public health layered defenses Swiss cheese model of @MackayIM.