Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
ice9 Profile picture
@__ice9
Sep 22, 2020 • 4 tweets • 2 min read • Read on X
About 60 percent of severe COVID-19 patients in the ICU exhibit clinical symptoms that look essentially indistinguishable from serotonin syndrome.
This fits evidence provided earlier showing elevated plasma serotonin levels in COVID-19.

Consistent with observed platelet activation (platelets store most peripheral serotonin) and damage to pulmonary endothelium (clears it from plasma)

Cyproheptadine and famotidine have been noted as effective in the treatment of serotonin syndrome.

aafp.org/afp/2010/0501/…

ncbi.nlm.nih.gov/pmc/articles/P…

Famotidine performs well in trials for COVID-19. I do not see any for cyproheptadine, but it shows up in protocols regardless.
Background on the broader context and etiology.

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with ice9

ice9 Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @__ice9

ice9 Profile picture
Mar 7, 2021
Again, the most useful points for a broad audience:

- get vaccine ASAP; prefer mRNA or Novavax; 2 doses far better than 1

- store RCT-validated early treatments: bromhexine-or-ambroxol + nitazoxanide-or-niclosamide, fluvoxamine, ivermectin

- N100 masks

For a medical audience:

- decide what the word "evidence" means:
a) "clinical results with appropriate sample(s) and endpoints"
b) "what huge lumbering institutions claim ex cathedra with no citations"
c) "what gilead et al. claim"
d) "peer best practices"

- take low-risk bets
If in doubt, *ask the patient*.

People have a fundamental right to participate in their own health-- *they already do so 99% of the time anyway*.

'This might help with X; it's a bit less certain; may cause Y side effects; studies say usually well-tolerated; do you want to try?'
Read 4 tweets
ice9 Profile picture
Feb 28, 2021
The continued failure to trial or use ITPP in critical care is an indictment against the regulatory and productive institutions of our supposedly-advanced (increasingly just shorthand for 'gridlocked') economy.

en.wikipedia.org/wiki/Myo-inosi…

It makes blood transport oxygen better.
It costs practically nothing.

Thousands of people already use it for athletic activities.

It has no side effects, is safe at huge doses in animal studies, and has never had a serious adverse event reported in the community ('that's informal' it's post-marketing surveillance..).
The fact that we are jamming tubes down people's throats before giving this, or for that matter even giving cyproheptadine, absolutely disgusts and appalls me.

>Oh that isn't proven

Yes. It. Is.

READ A BOOK; THEY ARE BOTH LITERALLY BASIC PHYSIOLOGY.

Read 5 tweets
ice9 Profile picture
Feb 28, 2021
Efficacy is nowhere near Novavax or the mRNA options (Pfizer/Moderna).

Much like Sinovac/Sinopharm(/CanSino), the tell for this is the headline numbers focusing solely on severe COVID-19 and ignoring mild/moderate cases.
Even for moderate, only 66% effective....

statnews.com/2021/01/29/jj-…

>One hope is that the efficacy of the Johnson & Johnson vaccine could rise if it is given as a two-dose regimen.

Obviously, yes! This is much more promising.
Single-dose frankly seems gimmicky, in a very specific sense:

This is effectively just offloading the debate about whether to halfway-dose existing vaccines to a new vaccine candidate instead-- one that has actually been trialed in this dosing schedule.
Read 5 tweets
ice9 Profile picture
Feb 26, 2021
A couple things about which I would like to be clear, from the now-big account (likely smaller over time):

1) do not ever @/DM to ask where I am or act like I owe you something-- pay me a bitcoin if you want that kind of attention, I know that is pocket change to some of you
2) I have a life outside of COVID-19 and a very, very detailed post history that is approximately two clicks away, depending on your choice of platform access method: search feature, "__ice9 <whatever topic>" papers generally do not become 'out of date' and a result is a result
3) I am frankly a bit bored. The acute disease was obviated months ago by dual entry inhibition. Not my problem if the west ignored it because it came from Iran, or due to statistical illiteracy or vile conflicts of interest (hi Gilead puppets 🎭). Fluvoxamine looks great too.
Read 7 tweets
ice9 Profile picture
Feb 1, 2021
Reminder:

If you test positive for COVID-19 and do not have fluvoxamine on hand, please consider enrolling in this clinical trial.

It's simple, remote, and important. It's a 50% chance to get fluvoxamine.

You can keep using other medications. Delivery is overnight shipping.
You can read the protocol summary here for more details on the trial if desired:

clinicaltrials.gov/ct2/show/NCT04…

My prior post about it is here:

Fluvoxamine was 100% successful in preventing hospitalization in an earlier RCT for use in mild COVID-19 within a few days of onset.

It was also associated with a 100% lower risk of progression to hospitalization in observational study.

Among the best.

Read 4 tweets
ice9 Profile picture
Jan 22, 2021
NAC apparently has antiviral effects vs. SARS-CoV-2.

chemrxiv.org/articles/prepr…

EC50 ~10μM
163g/mol * 10μM = 1.6mg/L
Plasma, as VoD=0.4L/kg

Hittable at 600mg oral q.i.d.:

pubmed.ncbi.nlm.nih.gov/2029805/

link.springer.com/article/10.100…

Unlike for vWF, Spike inhibition by NAC does not need IV.
Note I really do mean 600mg *q.i.d.* (4x/day) if tolerated; short half life. Safe in other studies.

link.springer.com/article/10.100…

Side note: strangely demanding PK study; very rigorous protocol. Hope participants were at least paid well. But they got us a number so I am pleased.
NAC may not have a large impact in monotherapy, given only EC50 is hittable (not EC90 except perhaps IV) and gappiness in plasma concentration peaks even q.i.d. (slightly compensated by permanent nature of damage done to exposed Spike copies).

But it looks like a good addition.
Read 5 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

Send Email!

:(