Jeremy Faust MD MS (ER physician) Profile picture
Sep 22, 2020 13 tweets 3 min read Read on X
📢2020 will be the deadliest year in modern American history.

We will see >3 million deaths for the first time ever.

In fact, well over that number.

Join me for a thread on basic epidemiology and how we count deaths and where things stack up, historically.

🧵 ...
We'll probably see 3.15 - 3.25 million deaths this year (from all causes).

That is around 300,000 or more will be more than was "expected"

But is that normal variance?

Is that just a "bad year" combined with a bigger population?

No and no.
How do we keep track of deaths in this country?

It's easy.

The CDC counts all the deaths, and divides by the population.

(We're not talking about deciding what caused the deaths. This is ALL CAUSES).

We express deaths as "deaths per 100,000 people."

So how are we looking?
In 2018, there were 867 deaths per 100,000 people, or 8.67 for every 1,000.

The number can vary (see below).

As you can see, we were on track to have around 2.9 million deaths in 2020, and somewhere around 870 and closer to 890 deaths per 100,000, if we had a really bad year. Image
With 250,000+ excess deaths already recorded by CDC and others, it is reasonable to guess that we'll be closer to 300,000 by Dec 31.

With over 330 million Americans, that's 3.2 million deaths, and a crude rate of 970 deaths per 100,000.

970 deaths per 100,000 is *a lot*.
That's around a 10% increase in all cause deaths.

A 10% increase in all deaths in *one year*

Usually, as per above, you might see a 1-2% change in either direction over a couple of years.

To have a 10% increase in all-cause deaths is truly impressive (and not in a good way)
Please note that there was *not* an increase in all-cause deaths around 2009 H1N1.

In fact, we had decent years in the US.

Some may argue that our rates would've been EVEN better those years but for H1N1.

Perhaps.

But whatever the effect, it didn't "overwhelm" other trends.
I mention this because I am *not* an alarmist by habit or disposition. I do not "fail to notice" when there's actually not a huge problem.

I tend to be fairly nihilistic about many things.

But with COVID-19, I can't ignore the data.

This is literally killing at historic rates.
In fact, to get to 970 deaths per 100,000 Americans, you have to go back to the 1960s!

Since then, we've added seatbelts, better cancer treatments, life-saving cardiac procedures. Image
So for us to be recording the same crude death rates as there were during the 1960s because of COVID-19 is LITERALLY backtracking on generations of progress.
In fact, @CarlosdelRio7, Zhenqiu Lin and I found it was more dangerous to be alive in NYC in 2020 than it was there in the early 1910s (!)

And when we compare COVID in Spring in NYC to 1918 H1N1 in Fall (the peak)? Covid=70% as bad, despite modern ICUs.
jamanetwork.com/journals/jaman…
All of this would be sad but useless information, if we were powerless to do anything.

But we are not.

If a vaccine rolls out in 2021, lives will be saved.

Wearing masks and limiting gatherings will keep us all alive long enough to get that vaccine.
In sum, the death rates we are seeing are truly historic.

I say this as someone who usually isn't alarmed by smaller (though epidemiologically important) phenomena.

We *can* influence how many live and die as a result of this.

Saving lives is *patriotic*

Let's do this.

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More from @jeremyfaust

Jun 8, 2023
I’m pleased to share my Commentary on the newly published *positive trial* finding metformin decreased Long Covid (Dr. Carolyn Bramante + ⁦@boulware_dr⁩)!

The therapeutic validation of long COVID. Lancet Infectious Diseases ⁦@TheLancetInfDisthelancet.com/journals/lanin…
“First, to our knowledge, this is the first high-quality evidence from a randomised controlled trial to show that the incidence of long COVID can be reduced by a medical intervention, metformin—an inexpensive treatment with which clinicians have ample experience…
“Second, the authors have, perhaps inadvertently, made an important contribution to medical epistemology…
Read 6 tweets
Jun 7, 2023
Quick poll.

Stop what you’re doing.

Put your hands in your lap.

Don’t move for 5 seconds.

Can you feel your hands or fingers tingling?

Even a tiny bit?
If you answered yes, were you aware of this before?
Thank you!
Read 5 tweets
Dec 22, 2022
Breaking: Covid-19 antiviral Molnupiravir not effective in preventing hospitalization and death among vaccinated patients with high risks.

It did shorten recovery time...

But that's not even the most interesting part...

open.substack.com/pub/insidemedi…
This is the first randomized controlled human trial that has studied Covid-19 outcomes among *only vaccinated* people that we’ve ever seen.

That’s an absolutely astonishing fact, if you think about it.

(Assuming I am correct here. Am I wrong?)
This gives us an unusual chance to look at all-cause mortality and all-cause hospitalization among infected vaccinated people during the Omicron era...

And to compare that the pre-Omicron and pre-vaccine era...
Read 14 tweets
Sep 12, 2022
The asymmetry of anecdote.

If you aren’t seeing a disease whose true prevalence is ~1% of the population and has a 10 day course, consider the fact that if you see 20 patients in a day, your odds that none will have it is about 82%.

And yet 3m Americans would have it.

1/
This means that your small sample size is fooling your “I can’t think beyond what I can see” big brain energy.

Proceed with caution before making any declarations.

It’s to notice and even share it. It is not okay to tell people “it’s over.”

However… 2/
However, if, say, 2 or 3 of your patients (out of 20) are positive 10%-15% of your patients!) and that happens to you more than once this week, the asymmetry of anecdote becomes important.

Your anecdotal experience could have at least 3 possible meanings.

3/
Read 5 tweets
Apr 28, 2022
Moderna files for emergency use for its Covid vaccine for children 6 months to 6 years.

They are saying 51% effective against symptomatic Covid for ages 6 months to 2 years and 37% for ages 2 to 6.

Sounds mediocre but here's why it may be MUCH better than that....
🧵
The data reflect a lot of cases during Omicron.

We know these vaccines provide very good short-term protection against infection, but that's a honeymoon phase.

That's important. But the way these vaccines were designed, and how they work best, is not really about infection...
What these vaccines have been shown to really do, over and over, is protect against severe disease and hospitalization, longterm consequences.

A pediatric trial can't be large enough to detect that. But the "immune bridge" strategy used both by Moderna and Pfizer has worked...
Read 11 tweets
Nov 22, 2021
Our new paper on deaths among adults ages 25-44 in Texas is out.

I want to highlight some key findings...
🧵

Causes of Death Among Young Adults by Race and Ethnicity in Texas During the COVID-19 Pandemic, 2020 ja.ma/3CChpFb via @JAMAInternalMed part of @JAMANetwork
Among Texas adults ages 25-44:
1. Covid-19 was the leading cause of death in July and December of 2020.

2. Covid-19 was the 2nd leading cause from the start of the outbreak thru December 2020.

3. Covid-19 was *by far* the leading cause of death among Hispanic residents.
4. Covid-19 was the leading causer of deaths among Black residents for July, and 2nd in December.

That level of data is more clearly shown (link): insidemedicine.bulletin.com/15084746495095…

5. Covid-19 broke into the top 5 leading causes of death among White residents just once (#5 in December).
Read 12 tweets

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