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More from @chamath

Chamath Palihapitiya

@chamath

Sep 6

We will be publishing our deep dive on India's economy next week, covering everything from how India's education system works to how the country's infrastructure development varies across different regions.

Like our previous deep dives, we will build from the ground up, assuming no prior knowledge.

Here’s what we’ll cover:

What is the current state of India's economy? How does it rank globally in terms of GDP, growth rate, and other macroeconomic indicators? What are the key sectors driving India's economy?

How is India's education system preparing its youth for the future job market? How has India's IT sector evolved and what is its contribution to the economy? How is the startup ecosystem in India contributing to economic growth and innovation?

What is the current state of India's banking system and capital markets? How does India's debt profile influence its economic stability and growth prospects? How is India addressing its energy needs and transitioning to renewable sources?

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Chamath Palihapitiya

@chamath

Aug 5

What I Read This Week…

The “Magnificent 7” stocks have lost over $1.7 trillion in market capitalization in just two weeks, with Nvidia's stock price decreasing 7% in a single day.

What's going on?

Investors are reassessing the lofty valuations of the largest technology companies, driven by concerns over their large investments in AI and mixed Q2 earnings.

Macroeconomic indicators are pointing to a weakening economy. The latest jobs report revealed new unemployment claims at their highest level since last August, while manufacturing has contracted for the fourth consecutive month.

These signs of economic weakness are prompting investors to anticipate Federal Reserve interest rate cuts starting in September, with the 10-year Treasury yield dipping below 4% for the first time in six months.

The United States is engaged in an increasingly complex battle to control the export of advanced AI chips to China, amid fears they could be used to enhance Chinese military capabilities.

Despite stringent export controls implemented since October 2022, a thriving underground market and creative corporate structures are allowing China to acquire them.

For example, in Shenzhen's bustling electronics markets, vendors openly offer Nvidia's most advanced chips, with some deals reportedly involving hundreds or even thousands of units.

One vendor claimed to have facilitated a $103 million shipment of over 2,000 advanced Nvidia chips from Hong Kong to mainland China.

Scientists have developed a novel class of antibiotics called GmPcides that shows promise in treating dangerous bacterial infections, including those caused by "flesh-eating" bacteria.

How do these new antibiotics work?

GmPcides are specially designed molecules that attack bacteria by breaking both their bacteria's DNA and cell walls. These antibiotics can kill bacteria whether they're growing or not, and even when they're hiding in colonies called biofilms – two scenarios that most regular antibiotics struggle to deal with.

While these results are encouraging, GmPcides are still in the early stages of development.

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Chamath Palihapitiya

@chamath

Jul 19

We will be publishing our deep dive on biotech at the end of this month, covering everything from how gene editing works to how AI is accelerating drug discovery and development.

This month’s deep dive on biotech focuses specifically on human therapeutics.

We will do future deep dives on agricultural biotech (e.g. GMO crops) as well as industrial biotech (e.g. biofuels and biodegradable plastics).

Like our previous deep dives, we will build from the ground up, assuming no prior knowledge.

Here’s what we’ll cover:

What is biotech? How do biotech companies turn breakthrough research into new products and treatments? How do small molecules, biologics, gene therapies, and other biotechnologies differ in their approaches and applications?

What are the stages of developing a new drug? Why are biotech companies generally higher-risk and more capital-intensive compared to other technology companies? Why are drug prices so high?

What is CRISPR and how has it advanced gene editing How have advancements in gene sequencing technologies shaped genomics and personalized medicine? What is Moderna's business model for commercializing mRNA-based treatments?

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Chamath Palihapitiya

@chamath

Jul 7

What I Read This Week…

The U.S. economy added 206,000 jobs in June 2024, exceeding expectations, but the unemployment rate rose to 4.1%, its highest level since November 2021.

What do these mixed signals mean for the Federal Reserve's interest rate policy?

The Federal Reserve's dual mandate requires it to promote maximum employment and price stability, so some see the unemployment rate increase as a factor that may lead to two potential rate cuts this year, with the first expected in September or November.

However, economists note that while the labor market is showing signs of moderation, it remains relatively resilient overall.

The investment world is increasingly focused on geopolitical risks, with many financial firms hiring geopolitical advisors and former government officials to help navigate a more complex global landscape.

What's driving this trend?

Investors perceive a fundamental shift in the global landscape, where geopolitical factors are increasingly driving inflation, amplifying risks, and complicating investment decisions.

This marks a departure from recent decades, when globalization typically led to reduced prices and risk across markets.

Key concerns include US-China tensions, conflicts in Ukraine and the Middle East, and political instability in South American countries like Venezuela, Bolivia, and Ecuador.

Europe's major militaries are facing significant personnel shortages, with countries like Germany, the UK, France, and Italy struggling to recruit and retain soldiers.

What's driving these recruitment challenges, and how are European countries trying to address them?

Contributing factors include competition from the private sector for skilled workers, inadequate living conditions on military bases, and changing attitudes towards military service among younger generations.

Some countries are exploring new recruitment strategies, including forms of conscription, while others are focusing on improving pay and living conditions to make military careers more attractive.

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Chamath Palihapitiya

@chamath

Jun 23

What I Read This Week…

Nvidia's market capitalization recently passed the $3 trillion mark, surpassing Microsoft and Apple as the most valuable company in the United States. Nvidia now also accounts for 34.5% of the S&P 500's growth this year.

So what's the problem?

Nvidia’s growth is partly driven by speculation about the future potential of AI, as well as Nvidia’s central role in shaping that future.

However, if these optimistic projections do not materialize as investors anticipate and Nvidia's stock were to decline, it would lead to a significant drop in the S&P 500 as well.

Anthropic released Claude 3.5 Sonnet this week, the first release in a forthcoming Claude 3.5 model family.

Notably, Claude 3.5 Sonnet excels in the Graduate-level Proficiency Question Answering (GPQA) assessment, which is designed to assess advanced academic understanding across various disciplines, testing complex reasoning and knowledge application typically associated with graduate-level education.

While the average PhD graduate scores 34% on this test and a specialized in-domain PhD scores around 65%, Claude 3.5 Sonnet has set a record with an impressive 67.2% score.

The ADVANCE Act, a bill aimed at boosting nuclear energy development in the U.S., has been passed by Congress and is now awaiting President Biden’s signature to become law.

The Act seeks to streamline processes for next-generation reactor development, position the US as a leader in the international nuclear market, and help keep aging reactors operational.

While the passage of this bill may accelerate nuclear technology development and deployment, its success will ultimately depend on how well it addresses longstanding concerns about nuclear safety, waste management, and public perception.

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Chamath Palihapitiya

@chamath

Jun 4

Deep Dive: Creator Economy - The Next Phase of Media

Every day, we make decisions about which products and services to consume. With countless options and categories to choose from, how do we end up selecting certain products over others?

More than $60T is spent annually by consumers on various products and services so this month’s deep dive focuses on the changing nature of how consumers are influenced.

In a world where we often lack the time or expertise to evaluate every option, the media initially drove consumption decisions by selling advertising about which products and services were best, most valuable, or most suitable.

To understand how media will drive consumption decisions in the future, we look to the past to investigate the underlying economic dynamics that have driven its evolution. Through our investigation, we uncovered four distinct phases of media:

We are already seeing evidence of this today, as influencers like MrBeast and Kim Kardashian build massive consumer goods businesses on the back of their captive audiences.

But they aren’t the only ones. We end our deep dive with an analysis of Elon Musk, the world’s first Mega-Influencer, who has built several massive businesses by following the playbook we outline in the deck.

You can read our full deep dive by following the link below:

chamath.substack.com/p/deep-dive-cr…

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