Dr Raghib Ali OBE MD MPH FRCP Profile picture
Sep 25, 2020 9 tweets 2 min read Read on X
I'm still seeing two widespread misunderstandings of this graph and the data.
The first is that cases are now as high as they were during the first wave – leading to unnecessary fear – and the second is that hospitalisations and deaths (and test positivity) are much lower now than when we had a similar number of cases – leading to unjustified complacency.
These case count (and test positivity) comparisons are completely misleading, because far more tests are being carried out now than in the first wave when they were only being done on those in hospital, not in the community.
Therefore, the number of recorded cases then were a huge under-estimation – the actual number of cases at that time is now known based on antibody testing. About 7 per cent or 4 million people have had the infection in England, and daily case counts can be inferred based on this,
as well as working backwards from the resulting hospitalisations and deaths. We are now at roughly 6500 cases a day on the basis of positive tests (the true number is about 9600 based on the ONS survey) This is about four times higher than the trough in July
but less than ten per cent of the peak in March (when there were about a million cases a week). So while there is certainly no need to panic based on case count, those who are only looking at hospitalisations and deaths are also in danger of being falsely reassured.
The infection fatality rate was not 20% during peak of first wave, as some people think based on this graph - it was about 1% based on actual number of infections detected by antibody tests. It is about half that now due to better treatments and younger average age of infections
Finally, it took less than three weeks to go from 6,000 cases a day on March 5th (50 recorded cases) to 300,000 cases a day on March 23rd. (2000 recorded cases). There was only one death on March 3rd, but a month later it was a thousand a day (with 3000 admissions).
This trajectory will not happen this time as cases are rising much more slowly but the situation can change quickly. By the time hospital admissions and deaths are going up rapidly, it is too late.
References are in my article: conservativehome.com/platform/2020/…

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More from @drraghibali

May 11, 2022
With restrictions having ended across all home nations, it’s time to have a look at the results of the 'natural experiment' that we've had in the UK since July 19 when policies diverged with England having fewer restrictions than Wales, Scotland & Northern Ireland since then.
1/6
While some described England’s approach as a "dangerous & unethical experiment", @CMO_England, I & others thought that ongoing restrictions in a highly immune population would simply postpone infections - not prevent them.
So what has happened with infection & death rates?
2/6
The graphs below show cumulative infections & deaths across the home nations from July 19 to April 9 (last date data available) & also from December 17 to April 9 when Omicron became dominant and show no significant differences in infection or death rates over that time.
3/6
Read 6 tweets
Apr 16, 2022
Studies like these (based on models) ignore what is now well-established i.e. key role of voluntary behaviour change in controlling Covid - with behaviour changing more in response to the level/fear of Covid ('voluntary lockdown') than govt. mandates
1/7
telegraph.co.uk/news/2022/04/1…
e.g. household visiting & mobility fell more in the week before lockdown than after lockdown came in. There is limited evidence that the govt. mandate produced a bigger fall than that which occurred anyway & we know that compliance with mandates is associated with level of risk
And we also saw what happened with the Omicron wave in December when, contrary to what was widely predicted based on models, voluntary behaviour changes led to an outcome similar to what was projected to happen with lockdown equivalent to step 2 of roadmap (only schools open.)
Read 7 tweets
Mar 30, 2022
With hospital admissions in England approaching the 1st Omicron peak (& hospitals being busier overall due to more non-Covid patients) & ONS likely to show a record no. infections this week, some are again calling for a return of mandatory measures assuming this will help but
1/6
evidence for this is lacking.
In the absence of better evidence, we look at the real world data from the natural experiment we've had since July 19 when the home nations diverged & we don't see any indications from the case, death or ONS survey data that England has fared worse
from have less mandates & relying more on public health guidance & people taking personal responsibility.
This is also true for the most recent Omicron wave where Scotland has had the highest infection rates & higher hospitalisations than first peak despite having more mandates.
Read 6 tweets
Mar 11, 2022
V. important paper published in the Lancet - the first peer-reviewed global estimates of excess deaths (the most reliable way to compare Covid deaths) over first 2 years of pandemic with findings that will surprise many & correct five widespread misconceptions / assumptions:
1/9
1. Far from the UK having the worst death rate in Europe (or even Western Europe) as many still think, it is actually 29th in Europe & 9th in Western Europe - below the Western European average & at the same level as France & Germany (no statistically significant difference) Image
W. Europe: 140.0 (133.5-146.3)
Italy: 227.4 (212.0-242.5)
Portugal: 202.2 (190.7-212.2)
Spain: 186.7 (181.3-191.5)
Belgium: 146.6 (135.8-156.3)
Netherlands: 140.0 (131.3-147.6)
UK: 126.8(122.3-130.9) Eng. 125.8(122.1-128.7)
France: 124.2 (120.5-127.7)
Germany: 120.5 (115.1-125.1)
Read 10 tweets
Feb 1, 2022
A note on excess deaths last wk:
1. They are 8.6% lower when comparing to the 5 yr avg which includes 2021 - unsurprising as it was peak of 2nd wave & no-one fully vaccinated - but
2. More significantly, they are also 3.3% lower than the 5 yr avg. for 2015-19 (pre-pandemic)
1/4
This is a huge contrast to the same week last year when there were 18,676 deaths (about 1.5 times higher than now) and deaths were 41.3% above the five-year average again illustrating the massive impact of vaccines and Omicron's decreased severity (& very low deaths from flu)
2/4
It is also consistent with point I raised in December re. '28 day positive test' measure over-estimating deaths due to Covid with Omicron (as shown below from @AlistairHaimes).
The proportion of 'due to' (72.9%) vs. 'involving' Covid is also lower than previous week (77.4%).
3/4
Read 4 tweets
Dec 29, 2021
There is understandable concern about increasing numbers of children being admitted into hospital with a positive Covid test recently. This needs urgent investigation but from what we know so far the data suggests the headline figures may be hiding a more complicated reality:
Firstly, the situation with children is in many ways similar to that with adults in that we need to distinguish between those who are admitted for a Covid-like syndrome versus those who are admitted with another condition (eg. abdominal pain) but have an incidental positive test
(There are also those who are admitted with a condition which Covid may have contributed to - and for the in-hospital figures those who were admitted before and now have a hospital-acquired infection.)
Read 10 tweets

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