Tom Inglesby, MD Profile picture
Sep 29, 2020 15 tweets 4 min read Read on X
White House press conference today on 150M Abbott rapid antigen tests. whitehouse.gov/briefings-stat… Some reactions to what was said at the event: 1/x
As background: coming arrival of the Abbott rapid antigen testing was previously announced by White House on Aug 27th. washingtonpost.com/health/white-h… 2/x
150M is substantial number of Ag tests. Their arrival will be very welcome. Important to plan for how these and other Ag tests coming on line should best be used. It’s a very big supply of testing, but not enough to meet range of potential public and institutional needs. 3/x
Important to use them for testing, screening in nursing homes, hospice, at risk populations, as described in afternoon event. But also prisons, food processing facilities, immigrant detention facilities, for example, where outbreaks have been large, widespread across country 4/x
Very good to suggest states use testing to make k-12 schools safer. Though systems will need to be set up to do that. E.g. 1 person can't do hundreds of tests upon school arrival. Depending on who is to be tested, may require team of people who need training to do tests right 5/x
Governor Tate (MS) said he will use them for universities and k-12 schools, which is a good use for these tests. But he said that all k-12 teachers can get tested on daily basis. That won’t be possible yet.... 6/x
... there are >3.5M teachers in K-12 schools. Testing all daily would mean 108M tests/month going to teachers alone. Not nearly enough for that at this point. 7/x
WH says 6.5M tests will be shipped this week. Not clear how quickly prodxn will ramp up in order to meet the range of testing needs described at event today. Early reports said Abbott will be ramping up production to 50M tests a month. Not announced when that will happen 8/x
If plan is to use screening tests (weekly? a few times a week?) to US K-12 students (~56M), university students (~15.3M) university faculty (~1.5M), and/or food processing facility workers (~150k), for example, then we'll need to expand antigen testing substantially 9/x
Hopefully there'll be more Ag testing coming on line over course of fall. Once produced at very high scale, getting them distributed to governors, local leaders, priority groups will be key and will be challenging. Need to inc. high risk communities, esp people of color 10/x
It was noted in press conf that we have done more testing than any other country so far. But that amount of testing unfortunately has been necessary, and continues to be, since the US has had more COVID cases and deaths than any other country. coronavirus.jhu.edu/map.html 11/x
The US even now continues to rank 20th highest of all countries in world in terms of new cases per day per 100,000 population. 12/x nytimes.com/interactive/20…
VP said in press conf that cases, positivity rising in 10 states in Midwest, near west. But cases actually increasing in 34 states+territories. Would have been better to give people full national picture + best pub health messaging to limit spread 13/x nytimes.com/interactive/20…
From Dr Atlas: “We know that there are areas of the country that have more cases. This is to be expected with more social mingling.” But he shouldn’t normalize higher cases from more mingling. And should refute latest "herd immunity" recommendations.. floridapolitics.com/archives/36964… 14/x
...Instead he should use his position to explain how social mingling causes more spread, and why that should be avoided. Should encourage responsible action: physical distancing, masks, avoiding large gatherings, > ventilation in buildings, testing, tracing, isolation. /end

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More from @T_Inglesby

Apr 12
The testing approach to H5N1 in cattle (in the link) needs to change substantially. @USDA_APHIS may be doing what it can now with minimal resources, but testing needs to expand, get simpler, more available and transparent.
1/xaphis.usda.gov/sites/default/…
The testing protocol is too complicated. It also only allows testing in cows that meet a specific profile. It only provides for limited number of tests per premises. 2/x
Given the quickly increasing number of farms w/ infected cows, the number of farms that are impacted that have had minimal interaction with others, the uncertainty on mechanism of spread and extent of disease, testing for H5N1 in cattle should change in a number of ways asap: 3/x
Read 8 tweets
Oct 30, 2023
I want to commend the Biden Admin for its new Executive Order on #AI - strong leadership & action on ensuring safe, secure development of AI, both to pursue all of it's great promise, but also to address serious biological risks and dangers (1/9)whitehouse.gov/briefing-room/…
The EO rightly commits to attracting world’s leading AI talent, to using AI to drive innovation. AI will help accelerate new vaccines + therapeutics, improve access to Dx tools, help w/ forecasting, etc. But EO recognizes strong governance also needed to prevent misuse (2/9)
The EO requires OSTP to establish a gene synthesis screening framework that reduces risks that dangerous viruses will be created de novo in a lab. It requires criteria & mechanisms for identifying high risk orders, screening customers, processes for reporting concerns (3/9)
Read 9 tweets
Dec 15, 2022
Important and good new COVID Winter Preparedness plan and actions announced today by Administration. Sets out plans of the Admin and its local gov & community partners to cope with rising COVID hospitalizations and mortality in country. 1/x whitehouse.gov/briefing-room/…
COVID cases and hospitalizations are up in most US states across the country, COVID deaths are rising nationally. And wastewater monitoring shows increasing COVID in all regions. So this Winter Preparedness Plan from the Administration is important 2/x nytimes.com/interactive/20…
Households can now order 4 more COVID home tests through COVIDtests.gov starting today. This is in addition to continued coverage of 8 free tests a month through private insurance and Medicare; thousands of free testing sites across country. 3/x
Read 11 tweets
Oct 25, 2022
So glad to moderate the panel conversation on Catastrophic Contagion and pandemic preparedness w/ distinguished colleagues Drs. Bemo, Hanefeld and Ryan, today in Brussels at the Gates Foundation sponsored Grand Challenges meeting 1/x ImageImage
A few themes and lessons coming out of that conversation: 2/x
Preparing and responding to epidemics can't be flown in from the outside. Needs to be built from the ground up with investment, strong leadership and good regional partnership 3/x
Read 11 tweets
Oct 24, 2022
We just completed the quite valuable Catastrophic Contagion pandemic exercise in Brussels, in partnership with @gatesfoundation and @WHO at the Grand Challenges annual meeting 1/x
The extraordinary group of participants were comprised of 10 current / past Health Ministers and senior public health officials from Senegal, Rwanda, Nigeria, Angola, Liberia, Singapore, India, Germany, and the US, as well as Mr. Bill Gates 2/x
The exercise simulated a series of WHO health advisory board meetings in a fictional pandemic set in the near future. Participants grappled with an epidemic located in one part of the world that spread rapidly to become pandemic 3/x
Read 17 tweets
Oct 18, 2022
The White House released the National Biodefense Strategy today. Compelling strategic goals, specific actions needed to get to them, many ambitious targets, clear assignment of lead agencies to get them done. Now its up to Congress to provide means to get all this work done 1/x
Hard-to-reach concrete goals include: 100 days to develop a vaccine, 130 days to manufacture enough for all of US, novel therapies produced within 180 days, 14 days to set up a clinical trial system, population uptake of vaccine at 85% and others along those lines. 2/x
Internationally, the US commits to help 50 countries to reach a range of specific epidemic related capabilities. This work is clearly important because epidemics that rage out of control anywhere are a threat to the US and the rest of the world. 3/x
Read 10 tweets

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