Alan Baxter ♛ Profile picture
Sep 30, 2020 19 tweets 3 min read Read on X
So: What is Wrong with COVID-19 Hotel Quarantine in Australia? A thread.

After difficulties with compliance to COVID-19 stay-at-home orders for returning travellers, Hotel Quarantine became the mainstay of infection management for these people in Australia. /2
But the efficacy of this program has varied enormously between states. Here I argue that the key difference lies in ventilation. /3
Think, for a moment, about the hotel rooms you have stayed in: Most would be serviced by one of two types of air handling: a) Natural ventilation modified by a split system air conditioner; or b) A mechanical (ducted) ventilation system. /4
Natural ventilation requirements are dealt with in Section 3 of AS 1668.2, which refers to BS5925. There are three methods that can be used to calculate requirements, but for the sake of brevity, I will refer only to one: Prescriptive opening size and location. /5
I will take the most problematic design that has full compliance with the Standard: In an enclosure containing 2 people with low metabolic activity, & over 2 square metres of floor space/occupant, openable openings must be no less in effective area that 10% of floor area. /6
The critical issue is that in cold weather, the occupants may choose to leave these openings closed. /7
Mechanical (ducted) ventilation systems are dealt with in Section 4 of AS 1668.2. There are two methods that can be used to calculate requirements; I will only discuss the most problematic example of the most simple method. /8
The prescriptive procedure incorporates minimum mandatory requirements for single enclosures (e.g. a hotel room): In an enclosure containing 2 people with low metabolic activity, & a room temperature at or below 27C, the outdoor air supplied should be >5 L/s/person. /9
In some cases, exhausted room air is partially reused to supply air for low occupancy spaces, such as corridors. /10
Clearly, as a generalisation, these standards are adequate for hotel rooms. However AS 1668.2 has many mechanisms for accommodating air-borne contaminants, which might not be considered in the case of low occupancy hotel rooms. /11
I would argue that as the point of Quarantine is to contain infection, with the clear expectation that some travellers will be infected. /12
The transmission of SARS-CoV-2 occurs via four routes: Direct contact, fomites (inanimate objects), droplet and aerosol. Analysis of super spreader events shows that most can probably be attributed to aerosol concentration in poorly ventilated spaces. /13
The standards for mechanical ventilation of enclosures for health care functions is given in Section 6 of AS 1668.2, & those for Infectious Isolation Rooms in paragraph 6: /14
The minimum outdoor airflow rate delivered to Infectious isolation rooms should be the greater of 10 L/s/person and 2 L/ square metre & should have a controlled room air pressure that is lower than that of adjacent enclosures. /15
Given that these requirements are much more demanding than those for low occupancy residential purposes, the majority of hotels are unlikely to meet them or be suitable for quarantine. /16
Distributed accommodation of separate cabins or bungalows, temporarily modified to ensure high natural ventilation, may be an effective alternative. /17
And one hotel style common in Queensland may also be relatively effective, as it consists of external corridors and naturally ventilated rooms, often ventilated by sliding doors to a balcony, which in warm weather, are often opened. /18
And this last point may be the most significant reason for the large difference in efficacy between hotel quarantine programs between the colder southern, and warmer northern states in Australia – incidental differences in ventilation adequacy between hotel designs. <end>
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More from @AlanBixter

Apr 18
I have been made aware of a major risk factor some people have that makes COVID a more serious risk for them than for others. As far as I know, there has not been a systematic study to quantify this risk, nor been any public health attempt to warn this group. /2
About 25% of the adult population have a patent foramen ovale. This is a hole between the left and right atria (upper chambers) of the heart. This hole exists in everyone before birth, but most often closes shortly after being born. /3
Normally, a PFO is not a significant problem. A small proportion of blood might pass through it from right to left sides of the heart, by-passing the lungs, but the proportion of air not oxygenated is not functionally significant. /4
Read 14 tweets
Apr 9
Prof Crab and I took a very similar set of domestic strategies to deal with COVID. I thought I might summarize them below: /2
But first, some basic principles: 1) COVID is primarily transmitted by aerosols - minute micro-droplets that waft in the air like cigarette smoke. 2) It is transmitted from an infected person to an uninfected person. /3
3) Some infected people are much more likely to transmit infections than other people. 4) Some locations are much more likely to allow transmission of infections. 5) Some behaviors are much more likely to allow transmission of infections. /4
Read 16 tweets
Dec 1, 2023
This is a tricky post. This time, 4 years ago, I was contacted by a person in a major government scientific organization. They said that they (pleural) had tried to warn the (then Morrison) government of an outbreak of a SARS-like virus in China. /2
They said that they had been warned directly by Chinese scientists, who were greatly concerned about the possibility of the disease spreading. They said that the government had not responded. /3
To put this in context, this was around the time of many major bush fires (Hawaii) resulting in a heavy demand for face masks. I posted the alert on Twitter & attempted to purchase N95/P2 masks from pharmacies. /4
Read 6 tweets
Sep 30, 2023
HOW TO USE COVID RATS.
The RATs that work best, test for the presence of COVID Nucleocapsid protein, a viral protein coat that surrounds the viral genome. It's function is critical for viral replication, so unlike the Spike protein, it has very little tolerance of mutation. /2
That means that these tests, by and large, work as well as they always did. Many people have the experience of feeling ill, testing, and finding they have a negative RAT, and then subsequently getting more ill, retesting, and finding that the RAT now tests positive. /3
The issue is that the tests were designed with a sensitivity that worked early in the pandemic, before vaccination and immunity from prior infection reduced viral replication in people infected. /4
Read 5 tweets
Sep 22, 2023
I had an GP appointment today. At the end of it, he asked me what I thought that we were experiencing outbreaks of unusual infections - his example was adults with childhood infections, mine was infections normally restricted to those immunocompromised, like monkey pox. /2
So I told him about the effect of COVID on the immune system: the widespread activation of CD4 T cells leaving them prone to activation induce cell death, and the fact that in adults, the thymus involutes, shutting down production of new T cells. /3
He looked shocked and asked me how long that state would last, and I told him that there is no particular reason why it would reverse, and that it clearly lasts as long as the pandemic as been around, so at least 3 years. Then he asked me to check their air filtration.
Read 7 tweets
Aug 4, 2023
Let's take a hypothetical: Imagine there was a hopelessly corrupt village that happened to be the capital of a small kingdom, rules by a chronically dishonest lay about. /2
And let's say - just as a hypothetical - than in addition to the very many other accusations of sexual assault that have not yet been investigated by the principal guards of the kingdom, one came to the interest of the king. /3
And so the legal processes - such as they were - set about trying the accused, but the people responsible for ensuring this done went to great lengths to say what a lovely bloke he was. /4
Read 10 tweets

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