Co-application of fluorescent quantum dot nanocrystals and therapeutics has recently become a promising theranostic methodology for cancer treatment. We developed a tumor-targeted lipid nanocarrier that demonstrates notable efficacy in gene delivery as well as tumor bio-imaging.
Coupling of aptamer molecules against the EGF receptor (EGFR) to the distal termini of lipid nanoparticles provided the carrier with tumor-specific recognition capability.
The cationic lipid component, referred to as O,O’-dimyristyl-N-lysyl glutamate (DMKE), was able to effectively complex with anionic small-interfering RNA (siRNA).
The hydrophobic quantum dots (Q-dots) were effectively incorporated in hydrophobic lipid bilayers at an appropriate Q-dot to lipid ratio. In this study, we optimized the liposomal formula of aptamer-conjugated liposomes containing Q-dots and siRNA molecules (Apt-QLs).
The anti-EGFR Apt-QLs exhibited remarkable EGFR-dependent siRNA delivery as well as fluorescence imaging, which were analyzed in cultured cancer cells and tumor xenografts in mice.
These results imply that the formulation of Apt-QLs could be widely utilized as a carrier for tumor-directed gene delivery and bio-imaging.
FI is a technique using fluorescent materials that emit visible light when excited by shorter wavelength or higher-energy light.
Recently developed Q-dots emitting fluorescence in the second near-infrared region (NIR-II) may further resolve the tissue penetration issue of the traditional Q-dots.
All my heart.
In addition, high levels of reactive oxygen species (ROS), which cause oxidative stress, are present in ASD patients.. .
Disproportional increase in intracellular ROS can induce cancer cell cycle arrest, senescence and apoptosis.
The overproduction of reactive oxygen species (ROS) has been implicated in the development of various chronic and degenerative diseases such as cancer, respiratory, neurodegenerative, and digestive diseases.
The involvement of reactive oxygen species (ROS) in some of the Down syndrome pathologies was initiated after assignment of the gene coding for Cu/Zn-superoxide dismutase (also known as Sodl) to chromosome21 in humans.
ROS and free radicals are generated in various human infectious diseases caused mostly by viruses in addition to bacteria and other parasites [71].

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It exceeds the bounds of mortal requirements.

It endures everlastingly and is not denied one who is entombed.

It passes over with the spirit to bear witness.

It is the great brightener.
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Be not as the ferryman who demands payment before his task is fulfilled, who bears upon the water the man who makes payment and no other.
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