We need a good hard look at the numbers and the longevity before we conclude that this is less effective than the mRNA based ones. bbc.co.uk/news/health-55…
Firstly it seems to rise to 90% when the first priming dose is lower. This might mean that less is more, and potentially anti-adeno responses might limit the boost. If so this is serendipitous as it will halve the cost of production of round 1
Secondly, in this trial they have evidence of reduced assymptomatic infection in vaccinees, suggestive of less transmission. This is something that we don’t know for the other vaccines thus far.
Thirdly it is cheaper to make and easier to distribute because it only needs a fridge/cold pack
No significant serious side effects thus far observed
Longevity of protection is key. Those that look best at 2 months my well not be the best at 6 if their are quantitative and qualitative differences in Ab and T cell responses between the difference platforms.
Lastly, the ChAdOx1 may not have the optimal antigen construct in it. Comparison if other adeno platforms in monkeys suggested that uncleaved stabilized Spike (as in moderna) is superior to the native protein in inducing upper respiratory tract protection.

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More from @stuartjdneil

19 Sep
There a lot of scientists in reflective mood as we face up the prospect of an autumn second wave of SARS CoV2 and what it may or may not mean, and in particular whether we can or even should contemplate further lockdowns. So I’ll add my twopenneth’ 1/n
At the beginning we didn’t heed the warnings from China and Italy until it was too late and we ended up playing catch up with a rapidly spreading virus that we didn’t understand. 2/n
The ability to test samples and act on that knowledge was rapidly outstripped by resources and the govt were woefully slow to alleviate bottlenecks in testing, diagnostics and PPE, all of which had been highlighted when wargaming a pandemic 2 years earlier. 3/n
Read 27 tweets
11 Mar
So hysteria helps noone. The point of flattening the curve is you mitigate the impact of SARS-CoV2 but minimize the the long term damage to the country. The way we get on top of this is by aggressive community testing and isolating infected people. 1/n
@PHE_uk job will made much easier if everyone follows the instructions: wash your hands, stay home and avoid visiting vulnerable people if you’re feeling ill. 2/n
More specific measures (eg sportscevents gatherings etc) should be brought in, but a Chinese style lockdown is not possible in a Western democracy. And ask yourself - what did Italy’s implementation of local lockdowns achieve? Very little it seems. 3/n
Read 5 tweets

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