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KizzyPhD Profile picture
@KizzyPhD
Dec 21, 2020 • 15 tweets • 5 min read • Read on X
Live view of our neutralization assay team scrambling to make yet another virus variant every time the media publishes about a new single amino acid change without context. 😒
Here is the context: you are going to read and hear about a million and one variant viruses, because viruses mutate by nature. It’s scary, I know. But, a couple of amino acids is not the same a whole whole new virus strain in the way that we’ve been taught to think about flu.
What is happening, often times, is selective pressure. As the virus transmits it learns how to be better at transmitting. This is why you hear “circulating faster than last variant”...
But, don’t get in a panic over it. There will take a large amount of genetic diversity to completely make the current vaccines useless... And, here is why:
Unlike monoclonal antibody therapies, vaccines (especially those using the whole spike protein) make polyclonal antibody responses. This means that the antibodies your vaccinated body will make will be able to bind the coronavirus spike in multiple places... not just one.
Remember in April when media had y’all scared over a mutation...
Then here came the D614G mutation that had reviewers on our neck... and then boom... in the mouse paper we added results showing “mRNA-1273 induces potent neutralizing antibody responses to both wild-type (D614) and D614G mutant SARS-CoV-2” nature.com/articles/s4158… Image
In all, please don’t be alarmed any more than you have been through this pandemic. The precautionary measures (ie. no travel) in the UK are in line with sensible measures following a regional virus spike.
Very reassuring data from @TheMenacheryLab et. al. on the Pfizer vaccine eliciting neutralizing antibodies to N501Y mutant SARS-CoV-2!
Read the Full Statement of the @WHO's "Emergency Committee on COVID-19 Advises on Variants, Vaccines" here >>>
who.int/news/item/15-0…
"... investigated SARS-CoV-2-S pseudoviruses bearing (...)
B.1.1.7 lineage spike protein with sera of 16 participants in (...) the (@pfizer) mRNA-based COVID-19 vaccine. The immune sera had equivalent neutralizing titers to both variants." biorxiv.org/content/10.110…
I’m just gonna post my boss here saying what I been done said. Maybe y’all will believe him.
The neutralization teams have a message:
"Moderna COVID-19 Vaccine Retains Neutralizing Activity Against Emerging Variants First Identified in the U.K. and the Republic of South Africa"

Sorry to those who I've been ignoring yin this regard for weeks lol
The pre-print is now live: mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants biorxiv.org/content/10.110…

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More from @KizzyPhD

KizzyPhD Profile picture
Jan 2
Sometimes, I start my lab meetings with a world view of “things”. It helps to provide a place where it’s clear science is second to sanity, inclusion, respect, etc.

I don’t even have to words to begin lab meeting next Monday,

My lab is at Harvard. Btw.
When there is war. I speak about loving everyone and peace, etc… and I remind people if they feel unsafe, tell me so I can provide a safe place.
When there is a viral uptick, I speak about safety precautions, freedom of masking, etc.
Read 5 tweets
KizzyPhD Profile picture
Nov 8, 2023
I’m up. Ever since my sister’s accident, I haven’t slept a bit. Soooo here is a thread on how a clinical trial drug likely saved her life, and moreover how Black respresentation amongst @DukeHospital’s surgery trial coordinators saved her life.
Sunday, my baby sister was in an accident. She had critical trauma and when she got to the ER was still alert and aware. With her level of trauma about 30% of people lose so much blood they don’t make it.
Knowing this, researchers have been studying clotting factors, and currently… in trial… is a drug that mimics the bodies inflammatory response to trauma to essentially speed the recovery response and the clotting… it nearly always works.
Read 9 tweets
KizzyPhD Profile picture
Jul 20, 2021
1/n: I’m in Louisiana for a non-COVID family emergency.

Said emergency makes me visit the ICU every day, three times a day. Been here since Saturday, and in the process I’ve seen

A
LOT. Image
2/n: Today, I sat beside a woman in the icu as she wept. I rode an elevator with a grieving wife. There are sirens. My family’s ICU unit is getting back crowded…
3/n: the front desk manager just warned us that 2 people visitation might be stopped “soon” (so say your goodbyes)
Read 6 tweets
KizzyPhD Profile picture
Jun 11, 2021
I just called into a meeting that EYE curated back in 2018 after interest in Coronaviruses got low. People were leaving our meetings so I rebranded it as the “emerging infectious diseases” meeting. When the pandemic started interest went up and it became a center-wide meeting.
The meeting today ended with “okay which principal investigator will take over”. It’s extremely hard to leave your baby behind… but… you know…
Go where you are loved. x My Dad
Read 8 tweets
KizzyPhD Profile picture
May 19, 2021
Today, my dad and my PhD dad get to witness me getting an honorary degree from UNC. I didn’t “walk” after defending my dissertation. So today... I walk.

So many full circle moments this year.

Honored.
1/n: I hope that no one to which I owe manuscript edits is reading this, but I felt a thread on my spirit as I listened to my UNC commencement address entitled "Home". instagram.com/tv/CPEMTyPHthd…
2/n: I just got an honorary doctorate from the institution (@unc) that I also received my PhD in Microbiology and Immunology in 2014. I cried during my "thank you", and I cried when I defended my dissertation, and I cried when @HarvardChanSPH announced my faculty appt last wk.
Read 8 tweets
KizzyPhD Profile picture
Mar 4, 2021
Congrats to the 2021 @unc graduates!!! ... It’s an honor to be your commencement speaker alongside Dr. Fauci! 💙

TARRRRRRRRR!!!
“She was also involved in several extracurricular activities, including serving as a representative on Student Congress, a delegate to the Association of Student Governments, a staff member in the Attorney General’s office and as a member of the science policy advisory group.”
This quote is a reminder to all students far and wide to not allow anyone to put you in a box. You are not “just” a PhD student. You are a citizen first. Do you, Boo.
Read 5 tweets

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