Woah - in the Crick testing pipeline, 10% of positive cases were the B.1.1.7 variant in the first week of December.

In the first week of January, it was 90%.

That seems crazy fast.
For context, this was relayed to staff by management in a "town hall" today.

Whilst some samples will have been sequenced, these values were determined by the absence of the Spike signal in the Thermo 3-gene PCR test.
Certainly, this data suggests that B.1.1.7 has a significant transmission advantage.
Whether that's down to enhanced ACE2 binding, or bigger viral loads, or some combination of the two, remains to be proven, I believe.
Further context - these tests are done for North London hospital staff (UCLH, Royal Free, etc), care homes, and Crick staff. So not a particularly representative sample of the population.
Do you want to know more?
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More from @xtaldave

17 Jan
"I know Kung-Fu" Image
"Remember the tooth" Image
"Make it so" Image
Read 5 tweets
1 Dec 20
Right, I know I keep banging on about Deepmind & Alphafold, but something I (a) do for a living and (b) am knowledgable about, is finally in the news, so suck it up.

*deep breath*
It's not available to all - the toys/source are (to the best of my knowledge) not available to other researchers.

So it isn't actually advancing science (yet). To do that it needs to be open.
And it is built on open depositories of protein structures (PDB) and sequences (Uniprot or equivalent), and on academic pieces of software (HHblits is in the mix, for example, I believe)
Read 7 tweets
30 Nov 20
Not to undermine this, and the work they are doing is excellent,l & important, but they did claim this at the last CASP.

Caveats then were that it only works on small proteins/domains in isolation, which is still super useful, but not what a lot of structural biologists do.
I await the publication with interest.
An RMSD of 1.6Å is damn good homology model.
Read 6 tweets

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