πππβ‘οΈ The ACE2 / RBD of π FELINE (cats) badger even properly bind the S1 of SARS-CoV-2 and have an entry efficiency superior than even a Yunnan bat!!! 
β‘οΈ Also the Feline Coronavirus (FCoV) and its mutation, FIP (Feline Infectious Peritonitis) matches SARS COV 2.
πIn this study, we demonstrate that stimulation of nsp16 2β²-O-MTase activity by nsp10 is a universal and conserved mechanism in coronaviruses, 1/4
πIn this study, we demonstrate that stimulation of nsp16 2β²-O-MTase activity by nsp10 is a universal and conserved mechanism in coronaviruses, 1/4
including FCoV (Feline Coronavirus), and that nsp10 is functionally interchangeable in the stimulation of nsp16 of different coronaviruses. Based on our current and previous studies, we designed a peptide (TP29) from the sequence of the interaction 2/4
interface of mouse hepatitis virus (MHV) nsp10 and demonstrated that the peptide inhibits the 2β²-O-MTase activity of different coronaviruses in biochemical assays and the viral replication in MHV infection and SARS-CoV replicon models. Interestingly, the peptide TP29 exerted 3/4
robust inhibitory effects in vivo in MHV-infected mice by impairing MHV virulence and pathogenesis through suppressing virus replication and enhancing type I interferon production at an early stage of infection.Therefore, as a proof of principle, the current results indicate 4/4
that coronavirus 2β²-O-MTase activity can be targeted in vitro and in vivo. π5/4
ncbi.nlm.nih.gov/pmc/articles/Pβ¦
ncbi.nlm.nih.gov/pmc/articles/Pβ¦
@MartinaSisters , FYIπ
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