CAS Special Project: Pathogen Host Adaptation & Immune Intervention (2018-2022)

The special project has 5 subprojects, including;

1. Research on virus traceability, cross-species transmission & pathogenic mechanism

Person in charge: Shi Yi; Shi Zhengli Image
Research direction (1) The traceability, evolution and transmission mechanism of new pathogens, aligns perfectly with Project XDB29010101.

Research direction (2) Molecular mechanisms of viral cross-species infection and pathogenicity, aligns perfectly with Project 31770175

Research direction (3) The interaction mechanism between virus and host, aligns perfectly with Project 31621061… Image
Here's more on Shi Yi: ImageImage
Important to note that the viruses of the 7896 clade from Latinne et al. (deposited under BioProject PRJCA002517) was part of the XDB29010101 grant.…
To wrap up this thread: On Sep 1, 2019 the summary meeting of the CAS Special Project "Pathogen Host Adaptation and Immune Intervention" was held. Chief scientist of the project, Gao Fu, and other experts reported on the achievements made in the past year.

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More from @TheSeeker268

26 Feb
"To the puzzlement of some overseas experts, China’s authorities seemingly failed to follow up with this testing in supply routes (for animals sold in Wuhan market) leading back to farms and animal breeders in certain regions of the country."
"I was a bit surprised that this work that you would expect to be done hasn’t been done" said @YanzhongHuang.

Daniel Lucey of Georgetown University in Washington said it was “frankly implausible” that such testing had not been done.
What more surprising is why some experts still believe the wet market theory holds up, when the earliest cases weren't even directly linked to the market, and China CDC itself abandoned the market origin theory.…
Read 6 tweets
19 Feb
The number, and genetic sequencing, of the first cases identified by China suggest coronavirus was spreading before early December 2019.…
"Many of the 174 cases had no known connection to the market that was initially considered the source of the outbreak, according to information gathered by WHO investigators"
"In examining 13 genetic sequences of the virus from December, Chinese authorities found similar sequences among those linked to the market, but slight differences in those of people without any link to it, according to the WHO investigators."
Read 4 tweets
13 Feb
For those still following the sordid tale: It's more than a year, and there's no trail of the virus until it caused an outbreak in Wuhan. No precursor strains or intermediary host, earlier patients had no market connection, & none of the animal samples tested positive for SARS2.
In the mean time, the closest know virus to SARS-CoV-2 was traced to samples collected from a mineshaft, 1000 miles away from Wuhan, where 3 miners died in 2012.

Doctors who treated the miners concluded that their illness was "caused by a SARS-like coronavirus."
Shi Zhengli's team went on multiple expeditions to collect viruses from the mine. They were brought back, stored and studied in the Wuhan labs.

I can hardly imagine them missing out on new SARS-like pandemic viruses.
Read 10 tweets
12 Feb
"To maintain objectivity, the WHO must contend with the fact that Chinese govt-supplied information is simply not reliable. To base factual findings solely on the word of China’s government places an unwarranted degree of trust in..a totalitarian state."…
"Embarek..gave a nod to Beijing’s extraordinary theory..that covid may have been introduced to China on frozen meat packaging. However, there are factual issues with such statements. By Beijing’s own statistics, covid cases spiked in China over a month before Italy & Spain."
"Beijing seems to have played some role in securing Tedros’ position as WHO DG in 2017. The year prior, the WHO removed Taiwan from its observer status at Beijing’s request. During the pandemic, this exclusion..has meant willfully endangering the lives of Taiwan’s 24M citizens."
Read 4 tweets
11 Feb
“This was supposed to be an unbiased investigation, something the world needs and deserves, yet we’ve seen no indication of impartiality or transparency——quite the opposite, unfortunately,”…
"This investigation must be continued and by an independent team that is not bound by the constraints of a host government that has erred on the side of saving face.”
“At the earliest opportunity after leaving China, the investigative team must release a detailed report and hold a press conference where they take questions from journalists, as well as from other virologists who have expressed skepticism on the findings,”
Read 4 tweets
10 Feb
"I was surprised to see some members of the team dismiss the accidental lab leak theory while seeming to suggest without any specific evidence the possibility that frozen food might have played a role," @jbloom_lab said.…
"I remain agnostic about the origins...But it's important to have a careful independent accounting of the research...that was being done in labs in Wuhan prior to the emergence of this pandemic, and it doesn't appear that this team accomplished that," @jbloom_lab said.
All told, "China was the big winner," said @YanzhongHuang . "We understand that they are doing their work within the parameters of the government. But you don't want to jump to a conclusion based on several hours of conversation with Chinese scientists."
Read 5 tweets

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