➡️1) (INSACOG) The Virologist 👉Shahid Jameel explained that a double mutation 👉in key areas of the virus's spike protein can increase these risks and allow the virus to escape the immune system; making the virus 👉more contagious and in some cases.
2) Is more probable that what emerged from my research 👉SARS COV 2 ORF 8 created a double mutation in the initial lineage.
👉The ORF8 protein has the characteristic of potentiating the virus and thus making it more virulent and infectious.
3) Furthermore ORF8 speeds up mutation times. 👇
4) ➡️ The genomic originale sequence of SARS COV 2, detected in this analysis, is very interesting, where the exact positions of the 👉ORF proteins emerge, which are responsible for both the increase in infectivity, and the enhancement and speed of mutation of the virus . 👇
5) ➡️ The position of ORF3a in S2 (SPIKE) is highlighted.

➡️ The positions of ORF6, ORF7a, 👉ORF8, in M ​​(MEMBRANE) are highlighted.

➡️ The position of ORF10 in N (CORE) is highlighted.👇
6) 7) ➡️ SARS COV 2 ORF8 protein is similar to Ig immunoglobulins that modulates pathogenesis, and exhibits a 👉rapidly evolving hypervariability that allows for the formation of 👉unique large-scale assemblies not possible for SARS-CoV, potentially mediating👇
In this table is possible observe the mutated genomic sequence👇
8) Interaction of the viral reservoir Bats with the ORF8 protein. 👇
9) Human SATS COV - SP - ORF8 - Ig 👉ORF8a - ORF8b 👇
10) the SARS COV 2 ORF8, genome sequence complete.👇

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More from @BidoliNicola

23 Mar
@gerdosi @gadboit @SunshineLife_21 @FatEmperor ➡️ 1) The relationship of the "bacteriophage nature" in SARS COV 2 is the following. Let's start from the meaning of a bacteriophage; they are obligate intracellular parasites, that is, they can ONLY survive using the resources of a host cell.
@gerdosi @gadboit @SunshineLife_21 @FatEmperor 2) They are capable of infecting all types of cells including 👉bacteria. When at the end of February 2019 I saw the photos of SARS COV 2, taken by the Marx Plank Institute, I was amazed. In this photo you could see how a tissue, affected by SARS COV 2, changed its shape creating
@gerdosi @gadboit @SunshineLife_21 @FatEmperor 3) sprawling filaments that responded to I don't know what genetic code of the virus. This photo always remained in my head until, after endless reading of papers dedicated to the topic in question, I came across this
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23 Mar
1) ➡️ The application detected four highly specific signature sequence regions that hit all 25 (available at the time of analysis) 👉Wuhan genomes.
➡️The detected signatures were found to occur in disparate locations on the genome. 👇 Image
2) ➡️ All four signatures were found to target all current 👉Wuhan genomes, and three out of four of these signature regions did 👉NOT sufficiently align to any known coronavirus or other organism in 👉NCBI BLAST databases.👇 Image
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22 Mar
➡️➡️➡️ SARS COV 2 👉Bacterial co-infection or Bacterial mutation?

➡️1) It is surprising is the limited reference to non‐viral co‐infections and super‐infections in COVID‐19.
This knowledge gap is puzzling considering the extensive clinical evidence, supported by
2) mechanistic studies in animal models, demonstrating that respiratory viral infections predispose patients to bacterial co‐infections and super‐infections.
Thus, most fatalities in the 1918 influenza pandemic were indeed due to subsequent bacterial
3) infection and similar observations were made during the later three 20th‐century influenza pandemics: the 1957 H2N2, the 1968–1969 H3N2 and the 2009–2010 H1N1 pandemics.

The New 👉COPD patients are colonised by bacterial pathogens even at the stable phase of the
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21 Mar
➡️The secrect of Ivermectin👇

1) Ivermectin belongs to the avermectin family, a group of macrocyclic lactones produced by the bacterium Streptomyces avermitilis.

Ivermectin is conventionally administered in the dermatological treatment of endoparasitic manifestations to
2) reduce and eliminate the Demodex folliculorum parasite present on the skin of patients.

the treatment of autoimmune disease by topical, oral or intravenous administration of an active agent, such as a compound of the avermectin family, such as ivermectin; one or more
3) organophosphate compounds, acetylcholinesterase inhibitors including an ethyl carbamate or a naturally occurring acetylcholinesterase inhibitor.

methods provided herein are compatible with a number of diseases implied by the presence of mites, in particular diseases in
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14 Mar
@virragoveritas @Baric_Lab @LisaGralinski @UNC_SOM @UNCpublichealth ➡️➡️➡️NHC potently Inhibits 👉MERSCoV👉SARSCoV and newly emerging👉SARSCoV2 Replication👇
Author paper:👉R. Baric,March 20,2020.
➡️BetaDN4hydroxycytidine(NHC) for the treatment of SARSCoV2👇
 ➡️NHC inhibits 👉MHV, 👉MERSCoV, and👉SARSCOV2, replication with minimal cytotoxicity
@virragoveritas @Baric_Lab @LisaGralinski @UNC_SOM @UNCpublichealth 1)➡️ Paper link:👇

➡️Both 👉Remdesivir (RDV) and 👉NHC reduce the production of infectious MERS-CoV virus in primary human HAE.
➡️Cultures were infected with MERS-CoV red fluorescent protein (RFP) at an MOI of 0.5 in duplicate
@virragoveritas @Baric_Lab @LisaGralinski @UNC_SOM @UNCpublichealth 2) in the presence of vehicle, RDV, or NHC for 48 hours, after which apical washes were collected for virus titration.
👉Whole-body plethysmography lung function was performed daily on four animals per group.
👉Asterisks indicate differences by two-way ANOVA with Tukey's
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13 Mar
🛑🛑🛑➡️ Paper by Shi Zhengli, Lin Fa Wang (2008). 👇

👉1) A group of SARS-like CoVs (SL-CoVs) have been identified in horseshoe bats. SL-CoV and SARS-CoV share identical genomic organizations and high sequence identities, with the main exception being the N end of the
2) spike protein (S), known to be responsible for receptor binding in CoVs. In this study, we investigated the use of the SL-CoV S receptor by combining a pseudovirus system based on the 👉human immunodeficiency virus 👉HIV with cell lines expressing human bat, civet or horseshoe
3) ACE2 molecules. In addition to the full length S of SL-CoV and SARS-CoV, a series of S chimeras were constructed by inserting different sequences of SARS-CoV S into the SL-CoV S backbone. Several notes were made from this study.
Read 15 tweets

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