@arkmedic @cpso_ca 1) Good place to discuss distrust. I am ex pharma. Pfizer extensively studied HCQ/CQ and AZ in combination as synergist. They had RCTs in Africa for drug resistant malaria - effective and safe in high dosages even for pregnant. They know it is anti-viral.
@arkmedic @cpso_ca 2) What happened to the small RCT for COVID that they did in March 2020 before they knew if a vaccine candidate would be proposed? Once there was a candidate then all these "danger" warnings went out on perfectly safe drug therapies.
@arkmedic @cpso_ca 3) Pfizer even put the combo CQ/AZ in their annual report. Oh, so now these drugs are dangerous and have all the doctors afraid of them. Really????
@arkmedic @cpso_ca 4) Pfizer's RCT of CQ/AZ in March 2020 dropped right off the map when Pfizer partnered for a COVID vaccine candidate. clinicaltrialsarena.com/news/pfizer-da…
@arkmedic 5) So by April 2020, they had partnered with BioNTech on a vaccine candidate. Spike Protein is very unstable. To do this vaccine, they had to do proline substitutions in the protein sequences. By April, that had been patented. pfizer.com/news/press-rel…
@arkmedic 6) What happened to the CQ(HCQ)/AZ drug therapy RCT was MONEY. pfizer.com/news/press-rel…
@arkmedic See Pfizer RCT for CQ(HCQ)/AZ in March 2020. clinicaltrialsarena.com/news/pfizer-da…
@arkmedic @cpso_ca You will find the dosages of the CQ/AZ combination in this paper. ncbi.nlm.nih.gov/pmc/articles/P…

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14 Mar
@richardursomd 1) Concept seems logical. It would seem that in young people, who are vaccinated to the S protein, they would also have a NK, CD4,CD8 t-cell response to the other COVID proteins. Sars1 research showed that there was t-cell response to the S,M, and N in young lab animals.
@richardursomd 2) Sars1 research showed that only aged laboratory mice developed severe fatal disease and surmised it was due to immune senescence. Then they found that young animals produced sufficient t-cell response to the virus that B-cell antibodies were never significantly produced.
@richardursomd 3) Sars1 research showed that ADE was associated with trying to use the N or M protein. There wasn't ADE with the S but the S is not stable. Pfizer and Moderna went ahead: described in this article about the prefusion S protein stabilization method. cen.acs.org/pharmaceutical…
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