Rajeev Jayadevan Profile picture
May 2, 2021 11 tweets 4 min read Read on X
Did elections contribute to the COVID-19 surge? We are always tempted to say yes. I decided to do a comparison. Surprisingly, the graphs I obtained from election & non election states are near-identical. This suggests that the wave is a seasonal surge in a geographic region.
1/9 ImageImage
The two images represent election states (where big outdoor gatherings occurred) on the right, and comparable non election states on the left. I have included two sets of pictures. The names of the states are on the graph. If you compare the timelines, it is near-identical.

2/9
The question is whether the surge would have occurred anyway, by pattern, and maybe the large election rallies amplified it to an extent.

This virus behaves in a wave-like pattern in most nations. The reason for the steep upward slope is exponential increase.

3/9
Exponential curves are gentle at first, when numbers are small.

As they increase by geometric progression, the time taken for a large number to double is the same as for a small number to double.

Hence it turns steep after a long and gentle rise.

(See pics)

4/9
As the surge breaks, the downtrend that follows also is exponential. That is an exponential DECLINE.

After the peak, the transmission apparently stops suddenly; the graph shows a steep downward slope (reason is unclear: definitely not “herd immunity”, weather or lockdown)

5/9
The same pattern is seen in multiple nations and might reflect the behaviour of the virus in a region. Human intervention is not enough to explain the sudden drop, as not all nations have done the same measures such as “lockdowns”. See my graph below that compares 6 nations.
6/9 Image
I am writing this thread just to show that our understanding of repeating waves of the pandemic are far from perfect.

Why the virus only “hangs around” in a region only for about 3.5-4 months, and returns 2-3 times a year is a mystery.

7/9
Solving this mystery might give us the key to outwit the virus & the pandemic.

e.g. Do a swarm of viruses have an genetic activation key that turns itself off at a particular time point?

Do they reactivate themselves into hyper mode after a period of quiet endemic spread?

8/9
Finding solutions requires out-of-the-box thinking.

My instinct is that there is something very important about viral behaviour that we are missing altogether. It might be the elephant in the room.

9/9

@PeterHotez @VirusesImmunity @doctorsoumya
@GKangInd @angie_rasmussen
Graphs obtained from covidindia. org
One can see that states like Maharashtra and Kerala (which have high numbers of overseas travel) have shown a sight endemic tendency between waves, the edge being rather jagged. Could be multiple separate introductions of the virus into the region, each with its own programming. ImageImageImage

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Rajeev Jayadevan

Rajeev Jayadevan Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @RajeevJayadevan

Apr 17
Tuesday meeting highlights 17 April

COVID returns sooner than expected.

This week, 6.7 - 7.3% of COVID tests turned positive, compared to nil the month prior.

Cases mild or asymptomatic (screening), severe disease not yet reported

(The last wave collapsed December 21)

1/6
While the return of COVID is only expected (cyclical), the short duration (3 months) of case-free gap is surprising.

This coincides with Bangalore waste water surveillance @TIGS_India showing viral load in all samples tested.

This means COVID is in circulation.

2/ Image
However, in most instances COVID tests are not done (multiple reasons, discussed earlier) and hence there might be a feeling that it has gone away.

Will monitor for more detailed clinical profile, this being only the first week or so.

3/
Read 7 tweets
Mar 6
Even among sedentary people, as little as ~4000 steps per day can reduce death / heart disease risk. Maximum benefit at ~9000.

There are many studies on step count, see thread. This paper also looked at how step count helped in a sedentary lifestyle.

1/5
bjsm.bmj.com/content/early/…
There is no such thing as a 10,000 steps requirement for health.

Benefits start at much lower levels.

This study received wide attention, attaching my earlier tweet

2/
In this study among older women, benefits (reduced mortality) were found at 4400 steps per day and maxed out at 7500.

3/

pubmed.ncbi.nlm.nih.gov/31141585/
Read 5 tweets
Mar 2
“Bed Rest” leads to loss of muscle

In healthy people over 60, just ten days of bed rest led to 1 kg muscle loss from the lower limbs.

Worse in people with illnesses.

In fact, there are very few real indications for “bed rest” now.
Exercise and early mobilisation is key.

1/6
Image
Image
Also called sarcopenia, this is a serious problem especially in the elderly, who might suffer an abrupt decline in their health as a result. Frailty creeps in, and once they lose their muscle/bone strength, falls and other complications occur.

Also affects younger people.

2/6
How to prevent muscle loss

1. Do not do bed rest unless absolutely indicated. It is often needlessly prescribed.

2. If rest is needed, one can do exercises while still lying in bed, preferably with expert help from a physiotherapist.

3. Moving the joints gently helps.

3/6
Read 5 tweets
Feb 17
Long COVID study from Japan, published in Nature answers many questions

🔹At 1 year, 20.7% had it, higher in adults.

🔹Most initial infections (89%) were mild, 60% had Omicron

🔹Vaccine has no preventive effect

1/3


Image
Image
Image
Image
🔹Risk higher in adults than children

🔹Adults 30-60 at high risk, women 2 x likely to get it

🔹Smokers, diabetics at higher risk

🔹If symptoms last more than 3 months, 60% continue to have it for over a year

🔹At 1 year, 13.4% had symptoms interfering with daily life

3/3


Image
Image
Image
Image
Read 4 tweets
Jan 29
Lung 🫁 function declines long term - even after *mild* COVID.

Major Denmark study measured PFT before, 6 months after and 2 years later. They compared with uninfected people.

The speed of decline leveled off at 6 months, but failed to improve back to baseline. See graph.

1/4


Image
Image
Image
Image
The accelerated decline among patients slowed at the 6 month mark, and eventually followed the expected “normal” age related decline. But it did not return to baseline.

DL co increased past the 6 month mark, but the was no corresponding improvement in breathing difficulty.

2/
The timeframe of initial infection was March 2020-January 2021. This means the participants were unvaccinated at baseline.

1/3 were reinfected later. By then, they had been vaccinated.

(What is less clear is how they made sure the controls remained non-infected for 2 years)

3/ Image
Read 5 tweets
Jan 1
Spent a week in Singapore, did not get COVID despite JN.1 surge. Sharing some travel tips to stay safe.

Masks, worn according to situation, keep viruses away. Here is what we did.

1. Airports are high risk, hence kept them on all the time

2. High risk while boarding

1/9
Image
Image
3. Airplane jet bridges are tiny tunnels that are crowded, kept masks on.

4. Until the plane takes off and is cruising, cabin isn’t well ventilated. People were coughing throughout, a common problem nowadays. Masks stayed on.

5. At meal times (cruising), masks came off.

2/9
6. Aircraft toilet is a tiny chamber, kept mask on.

7. After landing, until we reached a large enough space, masks stayed on. Soon after landing there is a period of low air exchange rate, and people talk. This is high risk.

8. Kept it on in the taxi, driver wore mask too

3/9
Read 9 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

:(