✨🧬 THE COVID THREAD SAGA, PT. I - MAGNESIUM: THE REAL VAXX (megaTHREAD) 🧬✨

Worried about COVID-19?

NO NEED TO, BROTHER:

MAGNESIUM WILL PROTECT YOU AND YOUR LOVED ONES FROM IT.

LEARN HOW 👇
Almost a year ago my father got infected. We were doing everything possible for him. We couldn’t afford to lose the pilar.

Back then I knew the basics of immunity and how a virus acts inside the cell.

But once I knew that my father had COVID?
I dedicated ALL my research & experimentation efforts to immunology.

I didn’t think it too much (FAST > PERFECT), I created him a immunity-specialized nutrition regimen ASAP. Nutrient timing, specific foods (and nutrients) combination, liquids, circadian rhythms...
Basic, but powerful. The result?

More than enough to defeat COVID.

Although he's already (kinda) old, he had very MILD symptoms, it was like a weak flu, but for 3 weeks.

Mild fevers, few to no coughing, he even had THE NRG to EXERCISE with me.
Like a scratch to a magestic oak.

We were AMAZED of how he reacted. Back then, the COVID cases we're TERRIBLE. Hospitalized people, dead after just a week, severe to insoportable fevers and if they made it through?

EXTREME FATIGUE. Long haulers.
Pops did not have those symptoms. None of it. Zero. Back to normal after a few days.

WHY I AM TELLING YOU THIS?

1- you NEED to realize that COVID is a weak ass virus and if you *REALLY* take care of your health?

It'll be a SCRATCH

2- part of that regimen had a high dose of...
MAGNESIUM.

Magnesium was the MOST important piece of his regimen. And ITS the MOST important nutrient against CORONA.

In this GIGA Thread you’ll discover HOW MAGNESIUM literally IMPEDES COVID from INFECTING YOU.
And no it won’t be a “magnesium boost ur immune system and strengthens your antioxidant system!!!!1!1!!" type thread

We'll dive DEEP, so fasten your seatbelts señoritas & homies

Here we go.

FIRST:
A) WHAT DOES COVID DO INSIDE THE CELL?

To understand The COVID Thread SAGA, you MUST understand this.

Historically, is believed that once a cell gets infected, it was beyond all help. That white blood cells (WBCs) were the only ones able to combat to combat pathogens.
The ONLY believed way to terminate the pathogen was to let NK Cells & Cytotoxic T cells to target & kill the infected cell.

Now,

Do you think that our cells, that went through MILLIONS of YEARS of evolutionary pressure, would let a pathogen do whatever it wants inside them?
Do you think that they are THAT NAIVE?

Of course not.

Infected cells (that aren’t WBCs) themselves are able to DETECT and DESTROY INTRACELLULAR PATHOGENS. This is called cell-autonomous immunity (let's call it intracellular immunity 👍)

pubmed.ncbi.nlm.nih.gov/23661752/
When a RNA virus (like COVID) enters your cell to do nasty things, the Toll-Like RECEPTOR 3 (TLR3) and retinoic acid-inducible gene I-like RECEPTORS (RLRs),

Are in charge of RECOGNIZING the virus and NOTIFYING ur MITOCHONDRIA thru MAVS (mitochondrial antiviral signaling)
Once ur mitochondria knows, it signals to the NUCLEUS to produce NF-kB which enhances the release of inflammatory cytokines and Type 1 Interferons, the latter inhibits VIRAL REPLICATION.

And Viruses KNOW this.
They’ve developed evolutionary strategies to reproduce and survive inside our cells, to evade their intracellular immunity.

Their main goal in ur cell is not to replicate.

IS TO RECRUIT, CONTROL and DAMAGE ORGANELLES. TO HIJACK YOUR CELL.

But why would they do that?
Because viruses ASSEMBLE INTRACELLULAR "VIRAL FACTORIES", made of organelles. Guess what's the goal of these factories.

EXACTLY.

TO REPLICATE THE VIRUS AND TO PROTECT VIRAL PROTEINS (from intracellular immunity)
"Transmission electron microscopy shows the ultrastructure of factories for the related iridoviruses. Numerous mitochondria (mi) accumulate around the factory (vf), where viral particles start to be seen (arrows)" (N) is the nucleus.

FYI IRIDOVIRUSES are kinda similar to COVID-
They are ADN viruses and orthocoronavidae are ARN based. COVID eventually will do the same.

Now, take a guess which ORGANELLE is THE MAIN TARGET:
A) THE ALL MIGHTY MITOCHONDRIA

B) da endoplasmic reticulum

C) da nucleus

D) da baby

hypefury add a poll feature or I'll nuke ur HQ God it's 2021 no mames cabron
CORRECT. Da Bab- The mitochondria. The NRG factories of your cells, the powerhouses, the ENGINES.

B) MITOCHONDRIA: FRIEND OR FOE?

Viruses damage the Mitochondrial DNA (mtDNA) to EVADE, CONTROL and INHIBIT the FIRST intracellular immunity response (above mentioned)
This mtDNA damage lowers your Mitochondrial Membrane Potential. MMP reflects how EFFECTIVE the mitochondrial processes are;

- The Krebs Cycle 🦀
- Electron Transport Chain
- Beta Oxidation of Fatty Acids
- And Oxidative Phosphorylation
In sinple words: MMP reflects how effective your mitochondria is at creating ATP (NRG).

High MMP means you have EFFECTIVE mitochondria. That they r healthy and functional. CONGRATS.
High MMP will let the Mitochondria have a healthy life cycle: Fussion (Mitochondrial Biogenesis), Fission, Mitophagy, Apoptosis

But low MMP? Will IMPEDE mitochondria to have a healthy life cycle.
This will keep dysfunctional and WEAK energy factories in your body. Since they can't go thru a normal life cycle.

Now, MMP not only it's dysrupted from the mtDNA damage, but viruses CAN ALSO CONTROL MMP TO THEIR WILL.
VIRUSES reduce MMP levels so that the cell continues to function & does not undergo through apoptosis (cellular death) letting them replicate as much as possible.

IT'S A MASTER HIJACK & ROBBERY. This is what happens during severe COVID:
"Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia"

Monocytes (WBCs) suffer FROM LOW MMP DURING COVID. COVID's MAIN TARGET IS THE MITOCHONDRIA.

And that's why Long Haulers suffer from fatigue.

embopress.org/doi/full/10.15…
Once COVID has replicated enough, it increases proteins that activate fission, ending in apoptosis (cellular death).

Now the COVIDs are free, they'll infect more cells and they repeat this cycle until conquest. W for COVID.

But...

If we add MAGNESIUM to the equation...
C) MAGNESIUM: THE REAL VAXX 💉

Before revealing u the magic properties of this mineral...

A QUICK SUMMARY:
1) EVERY cell can defend itself from pathogens

2) MITOCHONDRIA is the KEY PLAYER of intracellular AND extracellular immunity. Shitty mitochondrial = shitty immune system.
3) MMP reflects how good ur mitochondria creates NRG. How effective it is at it's processes.

4) High MMP = healthy life cycle. Low MMP = dysrupted life cycle. We want high MMP.

5) Viruses recruit organelles to create "viral factories", the mitochondria is the main target and
Is damaged & hijacked by COVID, this inhibits intracellular immunity and facilitates viral replication (from the factories)

Now, on MAGNESIUM:
Low Magnesium will dysrupt your MMP.

We know that Magnesium is IMPERATIVE for ALL mitochondrial processes. For ex, the krebs cycle. Where your cells use the food you eat to produce ATP, energy.

Magnesium activates 3 dehydrogenases (enzymes) in your mitochondrial matrix:
- Pyruvate dehydrogenase (mitochondrial pyruvate → Acetyl-CoA)

- Isocitrate dehydrogenase (isocitrate → 2-oxoglutarate)

- 2-Oxoglutarate dehydrogenase (2-oxoglutarate → Succinyl-CoA).

Magnesium determines how fast u produce NRG.
If you’re Magnesium deficient? (99.9% probable)

These enzymes WILL NOT function optimally. This’ll slow down the speed and efficiency of the krebs cycle, causing a lower energy production.
Magnesium ACTIVATES the F0/F1-ATP synthase, which is the "machine" where oxidative phosphorylation occurs, where ADP is converted to ATP.

OXPHOS ATP production is cucked without magnesium.

If you’re Magnesium deficient?

()
Guess what will happen to that "machine"?

It won’t work. It won’t produce ATP. Oxidative phosphorylation gets fucked up. And ur cells too.
Knocking down the MRS2 (magnesium transporter to mitochondria's membrane) dysrupts NRG production AND ur MITOCHONDRIAL STRUCTURE.

The Krebs Cycle was HIGHLY dysrupted, 24 metabolites significantly differed between normal cells (control) and MRS2-KD cells.
MRS2-KD dropped almost TWO FOLD the MMP level, reduced ATP levels in the nucleus, cytosol (the fluid inside ur cell), while increased mtATP

MMP = ΔΨmito (weird ass names ik)

I’ll explain the mtATP increase in a quote tweet.
This shows what happens when you r Magnesium deficient (99.99999999% probably you are).

Your MMP levels drop. Ur mitochondria get weaker. Your NRG production gets cucked.

Ur mitochondria and immune system get fucked up.
Now, time to connect da dots

If COVID lowers ur MMP to hijack the cell & replicate successfully, and a MAGNESIUM deficiency LOWERS MMP...

You’re creating the environment for COVID to succeed.

U r assuring a COVID infection without Magnesium

Basically u r fucked mate 😂🥂
BUT,

Here's where the mineral's magic comes in:

If we add MAGNESIUM to the equation, the MMP WILL RETURN to NORMAL.

NRG production will be restored. The TCA Cycle, Oxidative Phosphorylation, Electron TC will get back to normal.
It'll give your mitochondria the ability to break free from COVID’s chains, it will reactivate your cell and it’s intracellular immunity defenses.

It will be able to defend itself, it’ll inhibit viral replicating (through Type 1 Interferon).

And COVID?
Will DIE as the weak virus it is.

Literally you’re inhibiting a COVID infection with magnesium.

Now, you may think:

“oh don’t worry Alli i’m getting enough magnesium from my Mg Glycinate pills! im safe :D”

No you fucking don't. Even if it says "+%150 the RDI per X capsules"
You see, what REALLY matters is the ELEMENTAL magnesium. It’s the real quantity of how much Mag you’re getting.

11mg of ELEMENTAL magnesium per body weight (kg) is the quantity you should aim to get. Not what the virgin RDI says (is bullshit anyways).
Magnesium Chloride (MgCl) has 12% elemental mag. (60mg per 500mg), while Mg Glycinate has 14% (70mg per 500mg)

For MAXXing magnesium levels, i recommend to my clients MgCl, while MgGly is best before sleep (along L-theanine)

So if u weigh 75kg u should get MINIMUM 825mg DAILY
For food sources, stick with CACAO, HEMP SEEDS and ALGAE (chlorella, spirullina, etc. the darker the better)

Magnesium in spinach & grains is useless, a lot of anti nutrients in both.

However...
You MUST supplement with Magnesium. Everyone is so deficient in it. Depleted soils, stress, excess calcium, anti nutrients, SUGAR, stimulants (coffee included), alcohol, low magnesium in foods...

All these factors make almost IMPOSSIBLE to get enough Mag from diet alone
Homage @Grimhood and @ck_eternity_ for this Mg info, follow BOTH to achieve optimal health. I’ve learned a lot from them. And you will too.

Here you can buy the most based magne$ium (and herbs) in da universe:

grimmsapothecary.net/shop/?orderby=…
If u want to dive DEEPER into magnesium follow them and read this thread
There are MANY MORE ways in which MAGNESIUM defends you from COVID....
Which will be covered in the next episodes of this COVID THREAD SAGA.

In the following chapter: COVID RECOVERY & MAGNESIUM.

You will be a COCKBIG long hauler instead of a COVID longhauler 🖕😎🖕
ON THE MEANTIME? RT THIS THREAD TO PROTECT THE HOMIES FROM COVID.

SHARE THIS THREAD WITH YOUR LOVED ONES. MAG-PILL THEM (literally).

D) ME AND COVID ❤️

I’ve been trying to get COVID to test this (and other methods) on myself, but bruh

Even taking into account I’ve been going to the most crowded, public and "common" places, i still test negative week after week

That could mean two things:
1) Magnesium is doing its thing, along the other immune-methods im applying.

2) Or I sinply don’t resonate with COVID 🥂
Maybe I just got the COCKBIG-19. I’ll take that. If i test positive you’ll know it

finally, remember this: Maximizing your mitochondrial health (with Mag) is IMPERATIVE to defeat COVID and all existing viruses.

thread on this later
good fucking bye get sunlight eat cacao drink kefir have raw sex go to church and send $SOL to the moon 👍

SOURCES BELOW
[Mitochondria and microbiota dysfunction in COVID-19 pathogenesis] (sciencedirect.com/science/articl…)

[Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity] (sciencedirect.com/science/articl…)

[Mitochondria Membrane Potential] (sciencedirect.com/topics/immunol…)
[Combating COVID-19 and Building Immune Resilience: A Potential Role for Magnesium Nutrition?] (sciencedirect.com/topics/immunol…)

Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D (mdpi.com/2076-3921/9/9/…)
[SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing] (immunityageing.biomedcentral.com/track/pdf/10.1…)

Chapter 7 - Role of Nix in the Maturation of Erythroid Cells through Mitochondrial Autophagy (sciencedirect.com/science/articl…)
[Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past] (frontiersin.org/articles/10.33…)

Mitochondrial TOXICITY sciencedirect.com/science/articl…

[Virus factories: associations of cell organelles for viral replication and morphogenesis] (onlinelibrary.wiley.com/doi/epdf/10.10…)
[Signaling Organelles of the Innate Immune System] (cell.com/action/showPdf…)

[How does the oxidative burst of macrophages kill bacteria? Still an open question] (ncbi.nlm.nih.gov/pmc/articles/P…)

[Mitochondria and antiviral innate immunity] (ncbi.nlm.nih.gov/pmc/articles/P…)
[Chemical mechanism of ATP synthase.] (pubmed.ncbi.nlm.nih.gov/10506126/)

[The Involvement of Mg2+ in Regulation of Cellular and Mitochondrial Functions] (hindawi.com/journals/omcl/…)

[Cellular Self-Defense: How Cell-Autonomous Immunity Protects Against Pathogens] (ncbi.nlm.nih.gov/pmc/articles/P…)
[Intracellular immunity] (ncbi.nlm.nih.gov/pmc/articles/P…)

[Organelle dynamics and viral infections: at cross roads] (sciencedirect.com/science/articl…)

[Mitochondrial Mg2+ homeostasis decides cellular energy metabolism and vulnerability to stress] (ncbi.nlm.nih.gov/pmc/articles/P…)
[Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection] (sciencedirect.com/science/articl…)

[Type I Interferon Receptors: Biochemistry and Biological Functions] (jbc.org/article/S0021-…)

[Magnesium and T2D] (ncbi.nlm.nih.gov/pmc/articles/P…)
[Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia] (embopress.org/doi/full/10.15…)

[TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions] (ncbi.nlm.nih.gov/pmc/articles/P…)
[Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D] Note: This goes deeper into immunity. Add it on next thread. (science.sciencemag.org/content/341/61…)
Mitochondria are intracellular magnesium stores: investigation by simultaneous fluorescent imagings in PC12 cells] ([core.ac.uk/download/pdf/8…]

[[Viruses as Modulators of Mitochondrial Functions](sci-hub.se/10.1155/2013/7…)]

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