David Dowdy Profile picture
May 5, 2021 11 tweets 4 min read Read on X
One term I worry that we (as a public health community) have mis-messaged during the pandemic:

"herd immunity threshold"

A non-technical thread on why this is not "% of the population that needs to be vaccinated for us to return to life as normal while eradicating COVID-19"...
Disclaimer to the experts: This is for a non-expert audience.

Let's start with the virus that's currently circulating, and estimate roughly that - with no vaccine, no immunity, and "life as normal" - this person would infect ~5 other people before recovering (or dying).
Next, let's take a situation similar to the USA. Out of these 5 possible people infected, 2 might be vaccinated; 1 out of the remaining 3 might be someone who's already have had COVID; and 1 of the remaining 2 might be prevented by current behaviors (masks, distancing, etc).
This would lead to, on average, each person with COVID-19 infecting 1 other person. Meaning the epidemic will be *stable* (and decline very slowly as more people get infected).

This is the "herd immunity threshold". Note that case counts are falling ever-so-slightly. Not zero.
A key thing to note - while we may be at this stable level even now in places like the USA, case counts can easily rise again ("above the herd immunity threshold") if we relax behaviors such as distancing & mask-wearing too quickly.
The same thing can (and will) happen gradually over time as the virus mutates to become more infectious (for example, if the average person with COVID-19 would infect 6 people rather than 5, in the absence of any immunity and "life as normal").
On the flip side, if we vaccinate people faster, we reduce the number of cases (and deaths) faster.

It's not about getting to a threshold where the epidemic is stable, it's about how fast we can get the epidemic under control - meaning going *beyond* the herd immunity threshold.
Once again - we should be focusing on the *number of cases* (and how fast that number is falling), not on whether we are above or below a specific threshold.

Asking "have we reached the herd immunity threshold" is similar to asking "are cases going up or down right now"?
It's also important to remember that we are talking about "the average contacts of people with COVID-19 today," not "the average person".

Even though 40% of the population might be vaccinated, for example, this doesn't mean that 40% of current COVID-19 contacts are vaccinated.
As a result, simple calculations of "XX% of people must be vaccinated to reach herd immunity" may be over-optimistic (e.g., if the average COVID-19 contact is less likely to be vaccinated or distancing) or pessimistic (if they are more likely to have been infected already).
Take-home messages:
1) Focus on the case count, not on reaching a threshold.
2) The more people who are vaccinated, the better.
3) Activities like wearing masks & minimizing large indoor gatherings still have an important effect.
4) Progress is always slow, but it is being made!

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More from @davidwdowdy

Jul 8, 2022
Over half of all COVID infections in the US are now BA.5.

3 reasons why this isn't as alarming as it might seem:
- Rise in BA.5 has been gradual.
- Our immune systems are better prepared.
- Places hit first by the current wave have stabilized.

Some reasons for COVID optimism:
Gradual rise:

Whereas Omicron fully established itself in 1 month, BA.5 has taken 2 months to get to 50%.

And the size of the wave has been much smaller.

Meaning that any advantage BA.5 has over other subvariants is very small, compared to the advantage Omicron had over Delta.
Viruses evolve. But our immune systems also adapt.

One can always focus on the virus for bad news. But the overall trend is good news.

Apr-June 2022 was the least deadly 3-month period since the pandemic started. Even as transmission (e.g., test positivity, orange) has risen.
Read 8 tweets
Feb 25, 2022
New COVID guidance from CDC is out:


Now setting three "community levels". Previously based on cases + test positivity, now cases + new COVID admissions + % of hosp beds occupied by COVID.

A quick hot-take🧵on pros and cons of this approach.
Pro: It uses science.

This was based on measures that most accurately predicted deaths & ICU use in 3 weeks. Far better than arbitrary goals.
Pro: Test positivity was dropped.

% of tests positive is no longer a meaningful indicator, as testing varies so widely from one location to the next, and many tests are at-home tests that are difficult to track.
Read 10 tweets
Feb 11, 2022
What will COVID look like in 2022?

Nobody knows for sure, but here's my take on the 3 most likely scenarios.

Each with reasons why that scenario might (and might not) happen.

Take home: Depends on how long & strong immunity is, w/ most people now vax'd/infected multiple times.
Scenario A: 2022 is great.

COVID levels stay very low, at least until winter. Then we boost w/ COVID + flu vax.

Why so?
- Most people now have multiple doses of immunity (vax or infection).
- Many cases could be asymptomatic.
- Europe saw this in 2020 w much less immunity.
Why not Scenario A?
- Most countries haven't gone this long w/o a wave (or very stringent restrictions).
- Immunity vs infection doesn't seem to last that long: four vax doses haven't prevented a wave in Israel.
- Betting against the virus has not been smart so far.
Read 8 tweets
Feb 3, 2022
Some students have asked me: "If I want to engage w the press in my future job, what should I learn to do?"

Here's my top 10 list of responses to this question.

Bottom line: it's not about how smart you are.

Would welcome comments on this list from my journalist colleagues!
1. Treat journalists as allies, not adversaries.

Some scientists think journalists are looking for missteps that can be misquoted.

In my experience, this is not true. Journalists want to get the story right as much as we do.

Practice interviewing as friendly conversation.
2. Do your homework.

Don't go into an interview without asking what the story is about.

Spend a few minutes making sure your numbers are right. (I often keep tabs/notes open for reference.)

Think about the 2-3 key points you want to make, so you can make them repeatedly.
Read 11 tweets
Jan 24, 2022
Now that we've been living with Omicron for 2 months, we can use this wave to learn some lessons about
COVID in general.

First: This virus likely depends on a core group of people/settings for its spread.

We can surmise this by looking at the decline of Delta.
If 1 in 3 Omicron cases is reported, the # of cases in the US now is similar to # vax'd per day in April.

Yet Delta is falling much faster today (in winter) than cases were in April.

Why? Likely Omicron (unlike vax) is infecting the people who otherwise would transmit Delta.
And Omicron-induced immunity nearly wiped out Delta - at a time when <5% of the population had been infected w Omicron.

Meaning that a small fraction of people (those most likely to get infected & transmit) and settings
(large outbreak-prone gatherings) are sustaining spread.
Read 8 tweets
Jan 18, 2022
Though guilty myself, I wish we would stop naming waves according to variant ("delta wave", "omicron wave", etc).

This makes it seem like each wave is randomly triggered by a new variant - and there's nothing we can do about it.

But in reality, we are making a lot of progress.
Each wave can be explained by a combination of behavior change, winter effect, and immunity. Without invoking variants.

And though waning immunity has played a role so far, our overall immunity is building w time. (Why the average case now is milder than early in the pandemic.)
As shown below, we were able to live more freely in 2021. Largely because of vax/immunity.

This most recent wave isn't over - and we need to act w caution until it is.

But we are not at the mercy of each new variant. Though we're all tired, things should get better soon.
Read 4 tweets

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