Alina Chan Profile picture
May 13, 2021 91 tweets 50 min read Read on X
As scientists with relevant expertise, we agree with @WHO @DrTedros, US & 13 other countries, & EU that greater clarity about the #OriginsofCOVID is necessary and feasible to achieve. We must take hypotheses about natural & laboratory spillovers seriously.
science.sciencemag.org/content/372/65…
I'll be providing links to top threads and coverage of our letter in this thread. Thank you @jbloom_lab and @DavidRelman and the other 15 signatories!
These are the 18 signatories of the letter.
Coverage by @rowanjacobsen in MIT @techreview with surprising quotes from Dr Shi Zhengli from the Wuhan Institute of Virology.
technologyreview.com/2021/05/13/102…
“I stayed out of it because I was busy dealing with the outcome of the pandemic instead of the origin,” @mlipsitch says. “[But] when the WHO comes out with a report that makes a specious claim about an important topic … it’s worth speaking out.”
Shi Zhengli, said in an email that the letter’s suspicions were misplaced and would damage the world’s ability to respond to pandemics. “It’s definitely not acceptable,” Shi said of the group’s call to see her lab’s records. technologyreview.com/2021/05/13/102…
“We felt motivated to say something because science is not living up to what it can be...” @DavidRelman says. “For me, part of the purpose was to create a safe space for other scientists to say something of their own.”
Coverage by @AmyDMarcus @betswrites in @WSJ

"In many questions of science, it turns out the right answer is we don’t know the right answer and we need to look into it more." - @jbloom_lab

wsj.com/articles/scien…
Coverage by @jimgorman @carlzimmer @nytimes

"the recent W.H.O. report on the origins of the virus, and its discussion, spurred several of us to get in touch with each other and talk about our shared desire for dispassionate investigation" @MichaelWorobey
nytimes.com/2021/05/13/sci…
“I think it is more likely than not that SARS-CoV-2 emerged from an animal reservoir... I am concerned about the short- and long-term consequences of failing to evaluate the possibility of laboratory escape in a rigorous way. It would be a troublesome precedent.” @sarahcobey
Dr. Andersen, who reviewed the letter in Science, said that both explanations were theoretically possible. But, “the letter suggests a false equivalence between the lab escape and natural origin scenarios”

Do editors understand enemy peer review?
Coverage by @dctrjack in @CNET

The Science letter is an attempt to correct the record and push an investigation forward.

"The China-WHO joint study reporting was giving the public the wrong impression that a lab escape was extremely unlikely" (my quote)
cnet.com/news/calls-to-…
The accompanying letter from @ScienceMagazine Editor-in-chief @hholdenthorp

"China should allow for a dispassionate examination of the data and allow scientists to do what they are trained to do."

blogs.sciencemag.org/editors-blog/2…
Chinese doctors, scientists, journalists, and citizens shared with the world crucial information about the spread of the virus—often at great personal cost. We should show the same determination in promoting a dispassionate science-based discourse.
That's it for the first hour. I'll add more updates later today.

The signatories each have different opinions of how likely or unlikely a lab origin of Covid-19 is, but they are all incredibly brave to call for an investigation of the origins of this once-in-a-lifetime pandemic.
Worobey "thought a lot about how this research could create an ecological avenue to introduce a new pathogen to humans... 'As someone who does this, I’m very aware of the opening that creates for new viruses to get close to humans'”
news.yahoo.com/did-coronaviru…
Although David Robertson, head of viral genomics & bioinformatics, University of Glasgow "agreed with the authors of the letter that it was essential to find the origins of SARS-CoV-2 to prepare for the next pandemic, 'wasting time investigating labs is a distraction from this'"
Article by @DeborahNetburn in @latimes
Quoting @DavidRelman "if it’s a laboratory, then we’re talking about thinking much more seriously about what kinds of experiments we do and why.”
latimes.com/science/story/…
Thank you for the shoutout and solid journalism! @manuelansede @el_pais

"Among the 18 signatories are some of the researchers who led the study of the novel coronavirus... published in the journal Science, a showcase of the best of international science."
brasil.elpais.com/ciencia/2021-0…
Coverage in @NYMag

Quoting @jbloom_lab h/t @nytimes

“Anybody who’s making statements with a high level of certainty about this is just outstripping what’s possible to do with the available evidence.”

nymag.com/intelligencer/…
U.S. @RepAnnaEshoo (CA-18), Chairwoman of the Energy and Commerce Health Subcommittee:

“I applaud Stanford University’s Dr. David Relman and 17 other esteemed scientists on their open letter published in Science..."

eshoo.house.gov/media/press-re…
"In order to crush the virus and prevent future global pandemics, we must consider every hypothesis available and have non-partisan, independent, scientific experts conduct an investigation to inform our understanding of COVID-19 and similar infectious diseases."
"I stand ready to support the Biden Administration and our international partners in such an investigation of COVID-19 and SARS-CoV-2 origins, and I’m grateful to the scientists for leading this effort."
Coverage by @whippletom in @thetimes
“We know that laboratory accidents happen far more often than anyone would like to admit,” @DavidRelman said. “And that includes the very best labs, including those here in the United States.”
thetimes.co.uk/article/3a6417…
From the @washingtonpost editorial board:

“If the laboratory leak theory is wrong, China could easily clarify the situation by being more open and transparent. Instead, it acts as if there is something to hide.”

washingtonpost.com/opinions/globa…
Solid piece by @PolitiFact by @noahkimofficial and @KertscherNews

Quotes from Baric, Relman, and me from the @ScienceMagazine letter.

politifact.com/article/2021/m…
The lab leak theory "can be as simple as a researcher being infected by an animal or even another infected person in remote areas, and then bringing it into one of the most densely populated cities on Earth."
The gain-of-function hypothesis supposes both that a virus leaked from the Wuhan Institute and that scientists there tampered with it in ways that could have made it more infective or deadly. politifact.com/article/2021/m…
In the @BulletinAtomic by @MatthewField2

“On the same day that Biden looked toward the pandemic’s end, a group of 18 prominent scientists looked, figuratively, in the opposite direction, toward how it all began.”

thebulletin.org/2021/05/six-es…
Coverage by @ianbirrell

“In a highly significant move, 18 scientists from the world's top universities, including Cambridge, Harvard and Yale, have demanded further investigations into the origins of the pandemic.”

You forgot Stanford and Berkeley.

dailymail.co.uk/news/article-9…
Another @washingtonpost article on our letter: 18 preeminent scientists published a letter in the journal @ScienceMagazine saying a new investigation is needed because “theories of accidental release from a lab and zoonotic spillover both remain viable.”
washingtonpost.com/politics/2021/…
It quotes Prof Ian Lipkin who told former @nytimes reporter Donald McNeil Jr, regarding the WIV SARS virus research:

“That’s screwed up... It shouldn’t have happened. People should not be looking at bat viruses in BSL-2 labs. My view has changed.”
Lots of interesting new quotes from Peter Daszak and Ralph Baric in this @KHNews article by @ArthurAllen202

khn.org/news/article/w…
Baric “does not believe covid resulted from gain-of-function.. he signed the Science letter calling for.. investigation of his Chinese colleagues’ lab.. because while he “personally believes in the natural origin hypothesis,” WHO should arrange for a rigorous open investigation.”
“Many Chinese scientists were in contact with colleagues and journals outside the country as the pandemic emerged. Those communications may contain clues, Chan said, and someone should methodically interview the contacted individuals.”

khn.org/news/article/w…
🌟article @NathanJRobinson @curaffairs
"prominent biologists—including the world’s foremost coronavirus researcher published a letter in Science arguing that there needs to be a more serious investigation that takes the lab leak possibility more seriously"
currentaffairs.org/2021/05/the-st…
From @Dereklowe in @ScienceTM

“I also should link to this letter that has just appeared in Science, calling for greater clarity on the whole issue, and I don’t think anyone can disagree that it’s needed”

blogs.sciencemag.org/pipeline/archi…
“Certainly a lab-based origin is one possibility” - Centers for Disease Control and Prevention Director Dr. Rochelle Walensky

cnbc.com/2021/05/19/cdc…
From @edmontonjournal 🇨🇦 “sanctions should be imposed on labs and nation states that fail to meet the highest of levels of transparency around laboratory safety, something that sober scientific experts now make clear Chinese authorities have failed”

edmontonjournal.com/opinion/column…
From @politico by @renurayasam and @MyahWard

"18 leading scientists published a letter in the academic journal Science calling for further investigation to determine the origin of the pandemic that has killed 3.4 million people worldwide."
politico.com/newsletters/po…
I told @politico that "Much of the currently available information suggests that a lab-based origin of Covid-19 is plausible. There remains no sign of an intermediate animal host that could have passed the virus to humans in 2019."
"There are a number of plausible scenarios embedded in this label, ‘lab leak,’ and importantly, they include an unrecognized infection of a well-intentioned lab worker attempting to recover or study new coronaviruses from bats." - @DavidRelman
“Documentary evidence establishes that the bat-SARS-related-coronavirus projects at [WIV] used.. biosafety standards that would pose high risk of infection of field.. or laboratory staff upon contact with a virus having the transmission properties of SARS-CoV-2.” - @R_H_Ebright
"All of us wish we could say 'this is what happened,'" said Jesse Bloom @jbloom_lab who studies viral evolution.. and who helped draft the letter. "Objectively, it's not possible for scientists to say what happened with the current information."
usatoday.com/story/news/hea…
"But it's not too late to get a clearer idea of the origins of the SARS-CoV-2 virus, which causes COVID-19, Iwasaki @VirusesImmunity said. "A proper investigation.. will help uncover the origin of the virus.. We need to approach this issue with objective scientific approaches.""
Lawrence Gostin @LawrenceGostin O’Neill Institute for National & Global Health Law, Georgetown University: "China has not allowed a full, independent and rigorous examination of its territory, and it keeps insisting it happened in some other country contrary to all evidence."
Not sure how I missed this gem in @USATODAY by @kweintraub

@LawrenceGostin said "I would argue that the greatest failure is not even to define how it began or why it began." #OriginsOfCovid

usatoday.com/story/news/hea…
From @StanfordMed @DavidRelman

“Relman is no stranger to complicated microbial threat scenarios and illness of unclear origin. He has advised the U.S. government on emerging infectious diseases and potential biological threats...”

med.stanford.edu/news/all-news/…
“Scientists are also committed to the pursuit of truth and knowledge. If we have the will, we can and will learn much more about where and how this pandemic arose.”

#OriginOfCOVID19
We are finally in @factcheckdotorg

The record is finally being set straight - lab origin hypotheses of covid-19 have always been plausible and warrant a full investigation even if severely belated.

factcheck.org/2021/05/the-wu…
In @axios by @bryanrwalsh

The @ScienceMagazine letter “was the most prominent sign that the initial explanation for the emergence of SARS-CoV-2 — that it spilled over from an animal source — is coming into doubt.”

axios.com/gain-of-functi…
But I strongly disagree with @bryanrwalsh’s bottom line: “Should we discover that COVID-19 originated in research — however well-intentioned — a recent boost in public support for science could evaporate, which might be the greatest risk of all.”
The greatest risk of all is scientists showing that we are incapable of self-regulation and therefore not trustworthy.

Trust and support are built from transparency, owning mistakes and doing better, rather than covering up accidents and failures.
Great interview of @mlipsitch by @WBUR about the importance of having an international, balanced investigation of the #OriginOfCOVID19

“the answer should not be governed by what we want to hear or what we wish was true, but by where the facts point."

wbur.org/commonhealth/2…
Beautiful @WNYC @onthemedia podcast by @OTMBrooke setting the scene for our @ScienceMagazine letter - how lab leak had been cast as conspiracy, what the China-WHO study did and how that led to our letter calling for a true investigation of #OriginOfCOVID19
wnycstudios.org/podcasts/otm/s…
In @smh by @KnottMatthew

“The lab leak theory, regarded as fringe just a few months ago, has rapidly become mainstream in the US”

“a letter on May 14 in Nature by 18 prominent scientists calling for more investigation into the origins of the pandemic”

smh.com.au/world/north-am…
More about our @ScienceMagazine letter in @WSJ
"scientists from universities including Harvard, Stanford and Yale published an open letter.. calling for serious consideration of the lab hypothesis and urging research laboratories to open their records."
wsj.com/articles/wuhan…
And @HuffPost on our @ScienceMagazine letter!
"scientists from the U.S., U.K., Canada and Switzerland.. said origin theories “were not given balanced consideration” in the WHO’s report."
huffpost.com/entry/wuhan-re…
Another in @washingtonpost
May 14: Eighteen prominent scientists publish a letter in the journal Science, saying a new investigation is needed because “theories of accidental release from a lab and zoonotic spillover both remain viable.”
washingtonpost.com/politics/2021/…
Our @ScienceMagazine letter is in the @nytimes again:

“President Biden on Wednesday asked U.S. intelligence agencies to “redouble their efforts” to determine the origins of the coronavirus.”

nytimes.com/live/2021/05/2…
In Chinese language @bbcchinese
"A group of world-renowned scientists with relevant experience also recently wrote in Science magazine, criticizing that the previous WHO report did not take this [lab leak] hypothesis seriously enough."
bbc.com/zhongwen/simp/…
A flood of articles. @CNN

"We must take hypotheses about both natural and laboratory spillovers seriously until we have sufficient data," the scientists wrote in @ScienceMagazine

cnn.com/2021/05/25/pol…
In @TIME
"Health and Human Services Secretary Xavier Becerra called for a fresh investigation into the virus’ origins.. He joins prominent scientists who are similarly expressing skepticism about the early conclusions and urging further study"
time.com/6051414/donald…
In @ScienceMagazine itself
"virologists, epidemiologists and other scientists also called for further investigation.. accidental release from a lab and zoonotic spillover both remain viable."
sciencemag.org/news/2021/05/b…
In @Forbes
"scientists argued the lab accident hypothesis is still “viable” and deserves to be studied, and President Joe Biden said Wednesday U.S. intelligence agencies haven’t reached a conclusion on the lab accident.. or the animal spillover theory."
forbes.com/sites/joewalsh…
And @abcnews
"a group of renowned scientists earlier this month penning a letter in Science Magazine that concluded, "Theories of accidental release from a lab and zoonotic spillover both remain viable.""
abcnews.go.com/Politics/biden…
And @TheAtlantic

"a May 14 letter to Science magazine, signed by 18 scientists, called for “a proper investigation” and “dispassionate science-based discourse on this difficult but important issue”"
theatlantic.com/ideas/archive/…
And in the @nytimes @DLeonhardt thanks!

“From the beginning, the virus’s origin has been unclear. All along, some scientists, politicians and journalists have argued that the lab-leak theory deserves consideration.”

nytimes.com/2021/05/27/bri…
And the @spectator by @mattwridley
"a letter in Science magazine from 18 senior virologists and other experts — including a close collaborator of the Wuhan lab at the centre of the debate, Ralph Baric — demanded that such a hypothesis be taken seriously."
spectator.co.uk/article/the-co…
More in @nytimes 💫

“I’m completely open-minded about the possibilities,” @VirusesImmunity said. “There’s so little evidence for either of these things, that it’s almost like a tossup.”

nytimes.com/2021/05/27/hea…
In @BBC
"A prominent group of scientists criticised the WHO report for not taking the lab-leak theory seriously enough - it was dismissed in a few pages of a several-hundred-page report."
bbc.com/news/world-asi…
In Canada @CBCNews
"perhaps the biggest catalyst for another look at the virus's origins came earlier this month, with a letter published in Science, signed by 18 scientists, asking for a "proper investigation" into the origins of COVID-19"
cbc.ca/news/health/co…
"Even though there is very little evidence for any of these possibilities, that report basically said that the lab is extremely unlikely... So as a scientist, it feels a bit awkward without any data to conclude the likeliness of these scenarios in this manner." @VirusesImmunity
"[The WHO-convened study] was framed in such an unreasonable way.. Putting out a 300 page report on the origins of the virus that can't conclude anything except that it concludes very firmly that it didn't come from the lab — that's the lady doth protest too much." @DFisman
And in @Telegraph by @sarahknapton
@NimwegenLab "Reports may have created the impression that there is a consensus in the scientific community that the possibility that Sars-Cov2 leaked from a laboratory can be safely dismissed."
telegraph.co.uk/news/2021/05/2…
"However, there is no solid scientific basis for such dismissal. Almost a year and a half after the outbreak, there is still essentially no direct evidence available either for zoonotic spillover or for a lab leak."

"Moreover, the latter possibility has hardly been investigated"
In @TIME
"On May 14, 18 prominent scientists—including Ralph Baric, a virologist who has worked with Wuhan Institute of Virology chief scientist Shi Zhengli—published a letter in the journal Science that called for a new investigation"
time.com/6052346/china-…
In @CNET by @dctrjack

"a letter published in the eminent journal Science by 18 researchers called for a "proper investigation" into the origins of COVID-19. It wasn't the first call, but it seemed to reverberate the loudest."
cnet.com/news/the-coron…
And @Forbes
“This followed a group of 18 prominent scientists in mid-May deeming the lab theory “viable” and pushing for it to be more closely investigated.”

forbes.com/sites/jemimamc…
"In May, 17 scientists from Harvard, Yale, MIT, Stanford, and other leading institutions, including Chan, joined Bloom in a letter in Science calling for a thorough investigation of the Wuhan lab."
newsweek.com/exclusive-how-…
From @VanityFair @KatherineEban

"18 prominent scientists called for a “transparent, objective” investigation into COVID-19’s origins... Among the signers was Ralph Baric...

The scientific consensus had been smashed to smithereens."

vanityfair.com/news/2021/06/t…
In @Slate
“prominent virologists, epidemiologists, and public health researchers, published a letter in the journal Science... Soon after, President Joe Biden asked U.S. intelligence agencies to redouble their investigation into the virus’s origins”
slate.com/technology/202…
In @AlJazeera "The experts criticised the WHO-commissioned investigation, saying the two theories were not given “balanced consideration” while noting that only four of the 313 pages of the report addressed the possibility of a laboratory accident."
aljazeera.com/news/2021/6/6/…
In @voxdotcom by @umairfan

“We must take hypotheses about both natural and laboratory spillovers seriously until we have sufficient data,” reads a letter published in the journal Science in May 2021, co-authored by 18 researchers.

vox.com/22453571/lab-l…
In @nytimes @amyyqin @ChuBailiang

On finding the origin of Covid-19,
“It’s just bigger than any one scientist or institute or any one country — anybody anywhere who has data of this sort needs to put it out there” - @DavidRelman

nytimes.com/2021/06/14/wor…

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More from @Ayjchan

May 2
Ralph Baric's interview with @covidselect reveals he was on the Feb 1, 2020 phone call with Farrar, Fauci, Collins and the Proximal Origin authors.

Did he reveal his plans from 2018 with the Wuhan Institute of Virology to put furin cleavage sites into SARS-like viruses?

oversight.house.gov/wp-content/upl…Image
@COVIDSelect Baric said he forgot about the Defuse proposal & did not mention it at the Feb 1 call.

I believe Baric sharing Defuse would've prevented the publication of Proximal Origin and the use of it to dismiss a lab #OriginOfCovid in US gov and to the public. Image
@COVIDSelect Baric also could've told them at the Feb 1 meeting that novel SARS-like viruses were being used in infection experiments at BSL2 at the Wuhan Institute of Virology aka the Wild West according to Jeremy Farrar.
Read 10 tweets
May 1
Peter Daszak, EcoHealth Alliance testified he didn't know Wuhan Institute of Virology bred 🦇, studied pangolin samples, engineered viruses without leaving a trace, and continued to collect viruses after 2015.

So how does he know they didn't cause Covid?
Daszak said he didn't know if WIV had started experiments described in the Defuse proposal and 🚨had not even asked them🚨.

He only had virus sequences from samples collected up to 2015. He believed that the WIV would've shared more sequences from 2016-2019 if they had them.
Reminder: EcoHealth Alliance still has not shared the sequences for the WIV's 220 SARS-CoV-1-like viruses (2022 interview) or 180 unique SARS-like viruses in their prior work not yet characterized for spillover potential (2018 proposal).
Read 5 tweets
Apr 22
Those dismissing a lab #OriginOfCovid have had to make numerous concessions over the past 4 years.

We now know Wuhan scientists conducted risky experiments with novel SARS-like viruses at low biosafety & planned in 2018 to create viruses with the traits of the Covid-19 virus.
We also know the data on early cases & Huanan market shared by Chinese scientists do not shed light on #OriginOfCovid

Proponents of natural origin continue to argue that it is the totality of evidence that supports their hypothesis but this could be said for lab origin as well.
The latest defense for a natural #OriginOfCovid is that, if a lab leak had occurred, the Wuhan scientists would have acted all suspicious and essentially given the game away, thereby putting themselves, their colleagues & their families in immediate and deadly peril.
Read 8 tweets
Apr 18
Freedom of speech is important in academia & science but difficult to navigate when it comes to politicized topics.

With #OriginOfCovid, some scientists, journals & reporters have competing interests & may be blamed if research they conducted, funded or glorified caused Covid.
On Tuesday’s hearing, chief editor of Science said the scientific community contributed to politicization of Covid & it was wrong to paint 'lab leak' as a conspiracy theory.

There was widespread consensus, Democrat or Republican, that #OriginOfCovid remains unresolved.
Several representatives asked for forward-facing solutions but none were presented. Today, the media continues to hang onto mistakes & politics of the past.

When confronted, many scientists or journalists who misled their peers & the public on #OriginOfCovid make no apologies.
Read 10 tweets
Apr 11
The @BulletinAtomic Pathogens Project successfully unified experts from opposing ends of #OriginOfCovid, representing diverse disciplines & cultures.

The outcome was a set of practical and high impact recommendations that policymakers are taking note of.
thebulletin.org/2024/04/how-to…
@BulletinAtomic Please see this thread for highlights from the report:
@BulletinAtomic The point of assembling an international task force of experts with truly different view points on #OriginOfCovid and what qualifies as risky research was so that the consensus recommendations would be robust to attacks from angry people on both sides of this issue.
Read 12 tweets
Apr 11
Leaders of scientific funding agencies said Proximal Origin was a nice job. According to the lead author of Proximal Origin, Farrar, Fauci & Collins had advised and led them as they wrote the letter.

So why won't @NatureMedicine put these leaders in the acknowledgements?
Image
The only scientist acknowledged in Proximal Origin arguably contributed much less than these 3 leaders.

He wasn't even at the Feb 1 meeting organized by Farrar where #OriginOfCovid was hotly debated and Proximal Origin was initiated.
Beyond what @Bryce_Nickels pointed out in his letter to @NatureMedicine & International Committee of Medical Journal Editors, the Proximal Origin authors failed to point out that their funder(s) had been involved in the work.
nature.com/nature-portfol…

Image
Image
Read 7 tweets

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