I find this article really problematic nytimes.com/2021/02/05/opi…
It frames the early approvals of the Russian and Chinese vaccines, without phase 3 trials, as some sort of a vague perception problem, and not of real consequence.
Simultaneously, makes some vague jabs at "problems" with the western vaccines.
Then says one needs independent regulatory verification of all, but doesn't like the fact that WHO gives points to vaccines approved by stringent regulators.
Overall claim: all vaccines were approved quickly. Western vaccines a little less quickly than Russian, Chinese and Indian. But all legal. So, don't hate on the Russians and the Chinese.
And then this, about the Russian, Chinese and Indian governments. Image

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More from @PriyankaPulla

18 May
Dear doctors who are telling everyone that Covaxin is as good as any other vaccine, please also raise your voice about these horrendous violations in the clinical trial that was used to develop the vaccine are promoting. This is your job too.
The investigators in the trial of the vaccine you are promoting are refusing to give an informed consent form to the family of a deceased participant. You have a responsibility to protest this.
"the vaccine you are promoting", I meant.
Read 4 tweets
18 May
Many people are finding out the hard way that when vaccine manufacturers claim 100% efficacy against severe disease in a clinical trial, this doesn't translate to deal life. Vaccine efficacy against severe disease is probably very high, but not 100%.
And effectiveness - in real life - where people who have been excluded from clinical trials (the immunocompromised, for instance), is probably even lower. That's why we needed effectiveness studies for this country.
That's why we *saw* effectiveness studies done for vaccines like AZ and Pfizer. It matters. It's not just some fun academic exercise.
Read 4 tweets
8 May
Primary outcomes of the phase 3 trial of the just approved drug, 2-DG. What's the point of CTRI if investigators report primary outcomes like this? This doesn't mean anything!!!
How exactly is CTRI accepting such nonsensical descriptions of primary outcomes?
Read 4 tweets
8 May
Why is the world's most vaccinated nation seeing a surge bloomberg.com/news/articles/… (59% of the vaccinations in Seychelles were the poorly characterised Sinopharm vaccine, which has not published Phase 3 data yet)
I suspect that those who are confidently saying today that all approved vaccines across the world are the same will regret it at some point in future (it's an argument of expedience, just like the argument, a year ago, that everyone doesn't need masks)
My point is not that a vaccine with a lower efficacy estimate in a clinical trial is worse than one with a higher estimate(these estimates aren't comparable across trials). My argument is that poorly characterised vaccine is an unfair gamble to subject individuals/populations to.
Read 4 tweets
30 Apr
Good piece, although Mr Joshi has done worse than claiming we are the best. Including pushing favipiravir and Itolizumab, despite conflicts of interest.
While being an advisor to Biocon, he was also on Mumbai's Covid task force, which continues to prescribe Itolizumab.
How does one appear in a company's press conference for the launch of a drug, claim it is wonderful, and then also be a part of a state task force that prescribes the drug? Same applies to another noted pulmonologist.
Read 4 tweets
28 Apr
Someone I don't know from Adam wrote this email to Anvisa, demanding to know why they approved Sinovac, and not Sputnik/Covaxin, and marked me on it.
Naturally, I wasn't marked on any letter to CDSCO, demanding to know why Anvisa was saying what it is.
More from the genius. Pay particular attention to the part about how "most Indian companies probably don't follow GMP" and how Indian GMP is different from Western GMP 😂
Read 4 tweets

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