If your first dose was AstraZeneca and you live in Ontario, on almost all fronts, the preliminary data supports getting Pfizer as your second shot.

Lower risk, better protection, but higher rate of mild vaccine-related side effects.

I will be following up AZ with Pfizer.

…1/6
Ontario is NOT offering dose two of AZ faster than Pfizer. You have to wait 12 weeks no matter what. So you won’t get a second-dose faster by choosing AZ like you may in other parts of Canada.

…2/6
My decision also considers previous infections and annual boosters.

Repeated doses of virus-based vaccines such as Oxford–AstraZeneca tend to be increasingly less effective, because the immune system mounts a response against the adenovirus.

…3/6
If we get a third “booster” dose in 2022, it will almost certainly be an mRNA vaccine. Stronger “boosts” are triggered with added doses of THIS type of vaccine.

…4/6
In both UK and Spanish studies of mixed vaccines, there WERE higher rates of vaccine-related side effects like fever, but none that were severe.

…5/6
To be clear: Not getting AZ for dose two doesn’t mean you made the wrong choice making it dose number one.

With Ontario numbers where they were, you got some awesome third wave protection.

…6/6

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I want to respond to this thread, respectfully disagreeing with @ASPphysician that we should no longer use AstraZeneca in Canada.

Aside from a critical math error, there is an assumption which skews his opinion.

And a few other important things I feel were left out.

…1/11
First off, the incidence of ICU admission from AZ vaccine ranges from 0.787-3.85/100,000 as opposed to what is reported in Dr. Morris’ thread.

I calculated this using the same estimates of risk from @COVIDSciOntario that he used: 1:26,000 to 1:127,000.

…2/n
A big false assumption is comparing this risk of ICU from AZ to just one week of COVID ICU risk.

Personally, I got my AZ vaccine on April 20th; the earliest I can book Pfizer in my region is May 23rd. But let’s still assume a two week lag.

…3/n
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