Why Vents Don't Work in SC2 - Hypoxia

Hypoxia - a potentially dangerous condition in which there is decreased oxygenation in the body’s tissues.

The researchers found... as the disease became more severe, more IMMATURE RED BLOOD CELLS FLOODED INTO BLOOD circulation making up>
as much as 60% OF TOTAL CELLS IN THE BLOOD. By comparison, IMMATURE RED BLOOD CELLS MAKE UP LESS THAN 1%, OR NONE at all, IN A HEALTHY individual’s BLOOD...Immature red blood cells RESIDE IN THE BONE MARROW and we DO NOT NORMALLY SEE THEM in blood circulation.This indicates>
that the VIRUS IS IMPACTING the SOURCE of these cells. As a result, and to compensate for the depletion of healthy immature red blood cells, the body is producing significantly more of them in order to provide enough oxygen for the body....The problem is that IMMATURE RED BLOOD>
CELLS DO NOT TRANSPORT OXYGEN—only mature red blood cells do. The second issue is that immature red blood cells are highly susceptible to COVID...As immature red blood cells are attacked and destroyed by the virus the body is unable to replace mature red blood cells—which only>
live for about 120 days—and the ABILITY TO TRANSPORT OXYGEN IN THE BLOODSTREAM IS DIMINISHED.
...team was first in the world to demonstrate that immature red blood cells expressed the receptor ACE2 and a co-receptor, TMPRSS2, which allowed SARSCoV2 to infect them.>
findings... also show two significant consequences... First, IMMATURE RED BLOOD CELLS ARE THE CELLS BEING INFECTED by the virus, and when the virus kills them, it forces the body to try to MEET THE OXYGEN SUPPLY REQUIREMENTS by PUMPING MORE IMMATURE RED BLOOD CELLS OUT of>
bone marrow. But that just creates more targets for the virus.
Second, IMMATURE RED BLOOD CELLS ARE ACTUALLY POTENT IMMUNOSUPPRESSIVE CELLS; they SUPPRESS ANTIBODY production and they SUPPRESS T-CELL IMMUNITY against the virus, MAKING the ENTIRE SITUATION WORSE.>
I Got Nowhere Else to Go

When the team began exploring why dexamethasone had such an effect, they found 2 potential mechanisms.
First, dexamethasone SUPPRESSES the response of the ACE2 and TMPRSS2 receptors to SARSCoV2 in immature red blood cells, reducing the opportunities for>
infection.
Second, dexamethasone INCREASES the RATE at which the IMMATURE RED BLOOD CELLS MATURE, helping the CELLS SHED their NUCLEI FASTER. WITHOUT the NUCLEI, the VIRUS HAS NOWHERE TO REPLICATE.
ualberta.ca/folio/2021/06/…

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