Pr. Raoult's hospital has published the preprint of the cohort study of it 2,111 hospitalized patients.

A few comments...

mediterranee-infection.com/wp-content/upl…
The eye-catchers are definitely in the subgroup analysis:
The simple zinc-no zinc analysis yields no mortality benefit but the Hydoxychloroquine +Azythromicin +/- Zinc does, pointing to a large synergetic benefit.

Confirmation of the role of HCQ as an active Zinc ionophore?

Dr. Zelenko shall be pleased.
Another surprise is the large negative impact of corticosteroids (mainly dexamethasone) on patients with low CRP (<100).

The corticosteroid optimal point of intervention remains a real subject of investigation and the likely cause of the inconsistent observations.
Finally, more intriguing data in this original chart, suggesting that the efficacy HCQ+AZT is age dependent.

Can we have the same chart for HCQ+AZT+Zc please?

I ask because I wonder whether the strange rise & decline might be caused by a change in zinc deficiency by age/sex.

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Covid19Crusher

Covid19Crusher Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Covid19Crusher

13 Jun
The current struggle of Chile against Covid is daunting...

47% of the population is fully vaccinated, another 13% partially.

The government says that full vaccination corresponds to 58% the targeted population. Image
Nevertheless, critical bed occupation is reaching new pandemic highs.

The nation's capital is back into a strict lockdown.

The nasty P1 virus variant is now dominating the new cases. Image
However, there is little doubt that vaccination is blunting the fatality rate. Image
Read 8 tweets
5 Jun
The French study associating FIASMA use and much lowered intubation risk in Covid patients is now published.

IPW HR=0.58; 95%CI=[0.46-0.72]; p<0.001
ascpt.onlinelibrary.wiley.com/doi/abs/10.100…
The paper includes a useful list of FIASMAs, with names including:
• Clarityn, Promethazine, Hydroxyzine, Cyproheptadine
• Prozac, Fluvoxamine, Citalopram
• Ambroxol
A reminder of the power of early antihistamines in high-risk patients in this Spanish observational study in Spain (n=84):

• average 85 year-old
• 100% seropositive
• no hospital admission
• no death

Bravo!
sciencedirect.com/science/articl…
Read 4 tweets
3 Jun
Instructive, lowish 3x 12mg, ivermectin Randomized Controlled Trial from Egypt (n=164) in mild/moderate, young hospitalized Covid patients struggles for statistical power:
• Length of hosp. stay 9 vs 11 days p=.08
• Death 3 vs 4, non significant.

onlinelibrary.wiley.com/doi/10.1002/jm…
The comparison with the other Egyptian RCT (Elgazzar, mild arm) provides some important information.

The control groups differ greatly in age, however less people die in the older Elgazzar arm, pointing to more severe cases in Abd-Elsalam.
Unfortunately, that increased, age-controlled, underlying severity in Abd-Elsalam was met with a much lower dosing of ivermectin:

36 mg over 3 days whilst most patients in Elgazzar would have hit the cap of 4x24=96mg over 4 days.

(NB: average weight Egyptian 80kg)
Read 5 tweets
22 May
Sofosbuvir+Ledispavir antivirals perform well against Covid-19 in Egyptian single-blind randomized trial (n=250).

medrxiv.org/content/10.110…
A smaller open-label randomized trial (n=82) had some more mixed results, but suggested activity as well.

mattioli1885journals.com/index.php/acta…
This is not the first time that sofosbuvir is shown active against Covid-19.
Read 4 tweets
21 May
Discussion of under-researched potential role of TMPRSS2 inhibitor Spironolactone against covid-19.
preprints.org/manuscript/202…
The case for Spironolactone trials has been made before:

Read 4 tweets
13 May
The large double blind RCT (n=400) from Bangladesh pitting ivermectin+doxycyline vs placebo in a young population (avg. age 40) is now peer reviewed and published. Took only 7 months...

Faster healing / viral clearance when treated, no death vs 1.5%.

journals.sagepub.com/doi/10.1177/03…
Obviously, a question comes to mind: the same-seize Colombian JAMA ivermectin RCT showed an identical 2 day median faster recovery (10 vs 12), but without statistical difference.

So, why less "separation" or visible drug effect in the outcomes of JAMA?

2 hypotheses:
(1) the Bangladeshi control arm deteriorated 18% of the time, the treated arm only 9% (-9% abs, -50% rel).

Only 3.5% of the Colombian control arm worsened, leaving no headroom for the treated arm to outperform or reach stat. significance: it achieved 2.0% (-1.5% abs, -43% rel).
Read 5 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!

:(