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SP Kalantri Profile picture
@spkalantri
Jul 3, 2021 • 7 tweets • 3 min read • Read on X
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1/n
 #COVAXIN trial preprint was published few hours ago. Here is my summary of the trial- over 7 slides.

How was the trial designed?
2/n
 What was the primary and secondary outcome?
3/n
 Was #COVAXIN effective? (1)
4/n
 Was #COVAXIN effective? (2)
5/n
 Is #COVAXIN safe?
6/n
 Points to ponder in #COVAXIN trial
7/End
Study Conclusions

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More from @spkalantri

SP Kalantri Profile picture
Sep 19, 2023
The tradition of practical medical exams in India, especially bedside exams for final-year MBBS students, is centuries old. Bedside teaching is crucial, but it faces new-age challenges. Let me describe the issues shaping the landscape of medical education and exams in India. 1/n
India boasts an impressive 703 medical colleges, and these institutions collectively admit over 100,000 MBBS students annually. However, this sheer volume poses an immediate predicament: where will the patients for these university examinations come from?
2/n
Can they provide a diverse range of diseases and medical histories necessary to assess clinical skills effectively, or will the exam be lopsided—covering just a few organs while missing out on patients with other clinical disorders essential for a comprehensive assessment? 3/n
Read 22 tweets
SP Kalantri Profile picture
Aug 22, 2023
The NMC's @NMC_IND bid to cut links between medical professionals and the pharma industry is sending shockwaves through India's healthcare. But is this strict approach the solution? 1/n
Is the NMC's proposal too ambitious? Is it feasible to untangle deep-rooted ties between doctors and the drug world? Let me rewind to a case that could hold some answers. 2/n
In 2003, MGIMS @_mgims , a rural medical college, rewrote the playbook. Born in Sevagram, a village in eastern Maharashtra in 1969, it dared to reshape the bond between medical education and pharma influence. Here's how it rewrote the script. 3/n
Read 17 tweets
SP Kalantri Profile picture
Mar 3, 2023
𝗦𝗰𝗿𝘂𝗯 𝘁𝘆𝗽𝗵𝘂𝘀 is a devastating disease. At Sevagram, our healthcare providers regularly care for hundreds of patients with severe scrub typhus in the ICU. Unfortunately, around 15% of these patients do not survive. 1/n
A study from India published in the 𝗡𝗲𝘄 𝗘𝗻𝗴𝗹𝗮𝗻𝗱 𝗝 𝗠𝗲𝗱𝗶𝗰𝗶𝗻𝗲 a day before—caught my attention. CMC Vellore, PGI Chandigarh and JIPMER, Puducherry were some of the institutes that participated in the study. 2/n
This multicenter, double-blind, randomized, controlled three-arm trial from India published in the NEJM investigated which treatment (doxycycline, azithromycin, or their combination) was most effective in preventing death, complications, and fever. 3/n
Read 14 tweets
SP Kalantri Profile picture
Jul 24, 2022
1.Covid19 has taught us an important lesson. Uncommon or previously unheard diseases—𝗠𝗼𝗻𝗸𝗲𝘆𝗽𝗼𝘅, as an example— can suddenly arrive, when least expected. They trigger uncertainty, fear & irrationality. As in Covid19, only science can help us move from darkness to light.
2.The @NEJM on July 22 reported 528 𝗠𝗼𝗻𝗸𝗲𝘆𝗽𝗼𝘅
infections diagnosed between April 27 and June 24, 2022, in 16 countries —from Europe, Americas, Western Pacific, and Eastern Mediterranean region. Here are study findings:
3.Most infections occurred in young; 98% of the persons were gay or bisexual men and other men who have sex with men, 75% were white, and 41% had HIV infection.
Read 11 tweets
SP Kalantri Profile picture
Feb 11, 2022
What's in a name? That which we call an oath by any other name would turn out just as ineffective.”

Hippocrates or Charaka— their sayings lose relevance when medical professionals pay only lip service to the oath and fail to follow its spirit when they practice medicine. 1/13
"I swear by Apollo, the physician, by Asclepius, Hygeia, and Panacea and I take to witness all the Gods and Goddess." So goes the Hippocratic oath taken by medical graduates during their rite of passage.

How many medical graduates are familiar with the Greek Gods? 2/13
In the Hippocratic era, medicine was strictly meant for men. A medical school was a forbidden territory for women. So, there were no female physicians. Did the oath respect gender equality in medicine? 3/13
Read 13 tweets
SP Kalantri Profile picture
Jul 21, 2021
A long thread on snakebite- a neglected public health problem in India.

1/N
 India has the highest number of deaths due to #snakebites in the world. Snakes bite, injure, or disable hundreds of thousands of people and kill close to 58 000 Indians each year.
2/N
 Victims of snakebite often need ICU admission and access to ventilators and dialysis. Venomous snakebite is more expensive to treat than treating a heart attack or a stroke.
3/N
 People living in villages are at risk of snakebite because their housing conditions are poor and inadequate lighting makes it easy for the snakes to access their living spaces. Open-style habitation, open defecation and the sleeping on the floor often expose people to bites.
Read 27 tweets

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